The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Chemotransduction in the Carotid Body: K + Current Modulated by P O 2 In Type I Chemoreceptor Cells
Open accessAbstract
The ionic currents of carotid body type I cells and their possible involvement in the detection of oxygen tension ( P O 2 ) in arterial blood are unknown. The electrical properties of these cells were studied with the whole-cell patch clamp technique, and the hypothesis that ionic conductances can be altered by changes in P O 2 was tested. The results show that type I cells have voltage-dependent sodium, calcium, and potassium channels. Sodium and calcium currents were unaffected by a decrease in P O 2 from 150 to 10 millimeters of mercury, whereas, with the same experimental protocol, potassium currents were reversibly reduced by 25 to 50 percent. The effect of hypoxia was independent of internal adenosine triphosphate and calcium. Thus, ionic conductances, and particularly the O 2 -sensitive potassium current, play a key role in the transduction mechanism of arterial chemoreceptors.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632
Oxygen sensing in airway chemoreceptors
Youngson, C., Nurse, C., Yeger, H., & Cutz, E. (1993) · Nature · doi:10.1038/365153a0 · Cited by 458
Hypoxic pulmonary vasoconstriction
Moudgil, R., Michelakis, E. D., & Archer, S. L. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00733.2004 · Cited by 454
Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction
Post, J. M., Hume, J. R., Archer, S. L., & Weir, E. K. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.4.c882 · Cited by 451
Cellular oxygen sensing by mitochondria: old questions, new insight
Chandel, N. S., & Schumacker, P. T. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1880 · Cited by 391
Metadata
- Authors
- López-Barneo, J., López-López, J. R., Ureña, J., & Gonzalez, C.
- Venue
- Science
- Published
- 1988-07-29
- Volume
- 241
- Issue
- 4865
- Pages
- 580-582
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001409949
- Cited by
- 545
- References
- 1
- FWCI
- 11.46
- Type
- journal article
- Language
- en
- Open access
- green
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- López-Barneo, J., López-López, J. R., Ureña, J., & Gonzalez, C. (1988). Chemotransduction in the Carotid Body: K + Current Modulated by P O 2 In Type I Chemoreceptor Cells. Science. https://doi.org/10.1126/science.2456613
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
