The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction
Abstract
Cellular mechanisms responsible for hypoxic pulmonary vasoconstriction were investigated in pulmonary arterial cells, isolated perfused lung, and pulmonary artery rings. Three K+ channel antagonists, Leiurus quinquestriatus venom, tetraethylammonium, and 4-aminopyridine, mimicked the effects of hypoxia in isolated lung and arterial rings by increasing pulmonary artery pressure and tension and also inhibited whole cell K+ currents in isolated pulmonary arterial cells. Reduction of oxygen tension from normoxic to hypoxic levels directly inhibited K+ currents and caused membrane depolarization in isolated canine pulmonary arterial smooth muscle cells but not in canine renal arterial smooth muscle cells. Nisoldipine or high buffering of intracellular Ca2+ concentration with [1,2-bis(2)aminophenoxy] ethane-N,N,N',N'-tetraacetic acid prevented hypoxic inhibition of K+ current, suggesting that a Ca(2+)-sensitive K+ channel may be responsible for the hypoxic response. These results indicate that K+ channel inhibition may be a key event that links hypoxia to pulmonary vasoconstriction by causing membrane depolarization and subsequent Ca2+ entry.
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Cites
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Tsien, R. Y. (1980) · Biochemistry · doi:10.1021/bi00552a018 · Cited by 2,236
Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle
Standen, N. B., Quayle, J. M., Davies, N. W., Brayden, J. E., Huang, Y., & Nelson, M. T. (1989) · Science · doi:10.1126/science.2501869 · Cited by 1,190
Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels
Daut, J., Maier-Rudolph, W., von Beckerath, N., Mehrke, G., Günther, K., & Goedel-Meinen, L. (1990) · Science · doi:10.1126/science.2107575 · Cited by 593
Chemotransduction in the Carotid Body: K + Current Modulated by P O 2 In Type I Chemoreceptor Cells
López-Barneo, J., López-López, J. R., Ureña, J., & Gonzalez, C. (1988) · Science · doi:10.1126/science.2456613 · Cited by 545
Inhibition of hypoxic pulmonary vasoconstriction by calcium antagonists in isolated rat lungs.
McMurtry, I. F., Davidson, A. B., Reeves, J. T., & Grover, R. F. (1976) · Circulation Research · doi:10.1161/01.res.38.2.99 · Cited by 364
Potassium channels in cultured bovine adrenal chromaffin cells.
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The membrane properties of the smooth muscle cells of the rabbit main pulmonary artery
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Cited by
Archer, S. L., Huang, J. M., Hampl, V, Nelson, D. P., Shultz, P. J., & Weir, E. K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7583 · Cited by 819
Self-citationPhysiological and pathological responses to hypoxia
Michiels, C. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63747-9 · Cited by 559
Hypoxic pulmonary vasoconstriction
Moudgil, R., Michelakis, E. D., & Archer, S. L. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00733.2004 · Cited by 454
Self-citationA redox-based O2 sensor in rat pulmonary vasculature.
Archer, S. L., Huang, J., Henry, T., Peterson, D., & Weir, E. K. (1993) · Circulation Research · doi:10.1161/01.res.73.6.1100 · Cited by 362
Self-citationYuan, X.-J. (1995) · Circulation Research · doi:10.1161/01.res.77.2.370 · Cited by 296
Metadata
- Authors
- Post, J. M., Hume, J. R., Archer, S. L., & Weir, E. K.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 1992-04-01
- Volume
- 262
- Issue
- 4
- Pages
- C882-C890
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2181344473
- Cited by
- 451
- References
- 19
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Post, J. M., Hume, J. R., Archer, S. L., & Weir, E. K. (1992). Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.1992.262.4.c882
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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