Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 450

The DOI matches its Crossref record.

Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells

Diamond, S. L., Eskin, S. G., McIntire, L. V.·1989·Science
DOI 10.1126/science.2467379
Open this paper in CoChat — free account

Abstract

Wall shear stress generated by blood flow may regulate the expression of fibrinolytic proteins by endothelial cells. Tissue plasminogen activator (tPA) and plasminogen activator inhibitor, type 1 (PAI-1) secretion by cultured human endothelial cells were not affected by exposure to venous shear stress (4 dynes/cm 2 ). However, at arterial shear stresses of 15 and 25 dynes/cm 2 , the tPA secretion rate was 2.1 and 3.0 times greater, respectively, than the basal tPA secretion rate. PAI-1 secretion was unaffected by shear stress over the entire physiological range.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.2467379

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cited by

See all 450

Metadata

Authors
Diamond, S. L., Eskin, S. G., & McIntire, L. V.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1989-03-17
Volume
243
Issue
4897
Pages
1483-1485
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2467379
OpenAlex
W1996570657
Cited by
450
References
0
FWCI
11.86
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells. https://app.cochat.ai/papers/10.1126/science.2467379
The paper
Diamond, S. L., Eskin, S. G., & McIntire, L. V. (1989). Fluid Flow Stimulates Tissue Plasminogen Activator Secretion by Cultured Human Endothelial Cells. Science. https://doi.org/10.1126/science.2467379

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.