The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Control of Angiogenesis with Synthetic Heparin Substitutes
Abstract
Many diseases are dominated by persistent growth of capillary blood vessels. Tumor growth is also angiogenesis-dependent. Safe and effective angiogenesis inhibitors are needed to determine whether control of angiogenesis would be therapeutic. Heparin and certain steroids, administered together, can inhibit angiogenesis in a synergistic manner. This "pair" effect suggested that specific hydrophilic cycloamyloses may be suitable heparin substitutes. β-Cyclodextrin tetradecasulfate administered with a steroid inhibits angiogenesis at 100 to 1000 times the effectiveness of heparin in the chick embryo bioassay. This cyclic oligosaccharide also augments the anti-angiogenic effect of angiostatic steroids against corneal neovascularization in rabbits when β-cyclodextrin tetradecasulfate and a steroid are inserted into the cornea or applied topically as eyedrops.
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Citations
Cites
Polymers for the sustained release of proteins and other macromolecules
LANGER, R., & FOLKMAN, J. (1976) · Nature · doi:10.1038/263797a0 · Cited by 1,182
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Cited by
Borsig, L., Wong, R., Feramisco, J., Nadeau, D. R., Varki, N. M., & Varki, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061615598 · Cited by 714
Metadata
- Authors
- Folkman, J., Weisz, P. B., Joullié, M. M., Li, W. W., & Ewing, W. R.
- Venue
- Science
- Published
- 1989-03-17
- Volume
- 243
- Issue
- 4897
- Pages
- 1490-1493
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090436854
- Cited by
- 289
- References
- 1
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Control of Angiogenesis with Synthetic Heparin Substitutes. https://app.cochat.ai/papers/10.1126/science.2467380
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- Folkman, J., Weisz, P. B., Joullié, M. M., Li, W. W., & Ewing, W. R. (1989). Control of Angiogenesis with Synthetic Heparin Substitutes. Science. https://doi.org/10.1126/science.2467380
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
