Polymers for the sustained release of proteins and other macromolecules
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The rate of drug release can be governed through polymer modification, the development of new polymers, or the synthesis of copolymers.
“The rate of release can be governed through polymer modification, the development of new polymers, or the synthesis of copolymers.233–235”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [235]
Langer and Folkman showed that macromolecules such as proteins could be encapsulated in small polymer-based carriers.
“initial work done by Langer and Folkman 70 , which showed that macromolecules such as proteins could be encapsulated in small polymer-based carriers”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [70]
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Jung, H. N., Lee, S.-Y., Lee, S., Youn, H., & Im, H.-J. (2022) · Theranostics · doi:10.7150/thno.77259 · Cited by 282 · see citing works
Engineering and physical sciences in oncology: challenges and opportunities
Mitchell, M. J., Jain, R. K., & Langer, R. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.83 · Cited by 273 · see citing works
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Self-citation
- Authors
- LANGER, R., & FOLKMAN, J.
- Affiliations
- Boston Children's Hospital (US)
- Venue
- Nature
- Published
- 1976-10-28
- Volume
- 263
- Issue
- 5580
- Pages
- 797-800
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2052580681
- Cited by
- 1,182
- References
- 13
- Citations by year
- 2026: 23 · 2025: 33 · 2024: 37 · 2023: 47 · 2022: 44 · 2021: 68 · 2020: 35 · 2019: 28 · 2018: 47 · 2017: 30 · 2016: 32 · 2015: 25 · 2014: 41 · 2013: 33 · 2012: 31
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Update notices
- correction (1976-11-18)
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- sustained drug release, protein delivery, macromolecule delivery, biodegradable polymers, silicone rubber, controlled drug release
- MeSH terms
- Alkaline Phosphatase, Animals, Catalase, Delayed-Action Preparations, Inflammation, Molecular Weight, Muramidase, Polymers, Rabbits, Structure-Activity Relationship, Trypsin Inhibitors, Angiogenesis Inducing Agents
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