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Cited by 532

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Regulation of Proenkephalin by Fos and Jun

Sonnenberg, June L., Rauscher, Frank J., Morgan, James I., Curran, Tom·1989·Science
DOI 10.1126/science.2512642
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Abstract

Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site. Although this complex has been proposed to function as a transcriptional regulator in neurons, no specific target gene has yet been identified. Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c- fos and c- jun expression was detected. Fos-Jun complexes bound specifically to a regulatory sequence in the 5′ control region of the proenkephalin gene. Furthermore, c- fos and c- jun stimulated transcription from this control region synergistically in transactivation assays. These data suggest that the proenkephalin gene may be a physiological target for Fos and Jun in the hippocampus and indicate that these proto-oncogene transcription factors may play a role in neuronal responses to stimulation.

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Crossref · 10.1126/science.2512642

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Metadata

Authors
Sonnenberg, J. L., Rauscher, F. J., Morgan, J. I., & Curran, T.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1989-12-22
Volume
246
Issue
4937
Pages
1622-1625
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2512642
OpenAlex
W1988568219
Cited by
532
References
2
FWCI
19.92
Type
journal article
Language
en
Open access
closed

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