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Self-Assembled Organic Monolayers: Model Systems for Studying Adsorption of Proteins at Aurfaces
Abstract
Self-assembled monolayers (SAMs) of ω-functionalized long-chain alkanethiolates on gold films are excellent model systems with which to study the interactions of proteins with organic surfaces. Monolayers containing mixtures of hydrophobic (methyl-terminated) and hydrophilic [hydroxyl-, maltose-, and hexa(ethylene glycol)-terminated] alkanethiols can be tailored to select specific degrees of adsorption: the amount of protein adsorbed varies monotonically with the composition of the monolayer. The hexa(ethylene glycol)-terminated SAMs are the most effective in resisting protein adsorption. The ability to create interfaces with similar structures and well-defined compositions should make it possible to test hypotheses concerning protein adsorption.
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Cited by
Banerjee, I., Pangule, R. C., & Kane, R. S. (2011) · Advanced Materials · doi:10.1002/adma.201001215 · Cited by 2,749
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,010
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
Ostuni, E., Chapman, R. G., Holmlin, R. E., Takayama, S., & Whitesides, G. M. (2001) · Langmuir · doi:10.1021/la010384m · Cited by 1,799
Self-citationEngineering cell shape and function
Singhvi, R., Kumar, A., Lopez, G. P., Stephanopoulos, G. N., Wang, D. I. C., Whitesides, G. M., & Ingber, D. E. (1994) · Science · doi:10.1126/science.8171320 · Cited by 1,453
Self-citationKeselowsky, B. G., Collard, D. M., & García, A. J. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10537 · Cited by 949
Metadata
- Authors
- Prime, K. L., & Whitesides, G. M.
- Venue
- Science
- Published
- 1991-05-24
- Volume
- 252
- Issue
- 5009
- Pages
- 1164-1167
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995829317
- Cited by
- 1,831
- References
- 0
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Prime, K. L., & Whitesides, G. M. (1991). Self-Assembled Organic Monolayers: Model Systems for Studying Adsorption of Proteins at Aurfaces. Science. https://doi.org/10.1126/science.252.5009.1164
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
