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Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific
Abstract
Three cellular homologs of the v- erbA oncogene were previously identified in the rat; two of them encode high affinity receptors for the thyroid hormone triiodothyronine (T 3 ). A rat complementary DNA clone encoding a T 3 receptor form of the ErbA protein, called r-ErbAβ-2, was isolated. The r-ErbAβ-2 protein differs at its amino terminus from the previously described rat protein encoded by c- erbA β and referred to as r-ErbAβ-1. Unlike the other members of the c- erbA proto-oncogene family, which have a wide tissue distribution, r- erbA β-2 appears to be expressed only in the anterior pituitary gland. In addition, thyroid hormone downregulates r- erbA β-2 messenger RNA but not r- erbA β-1 messenger RNA in a pituitary tumor-derived cell line. The presence of a pituitary-specific form of the thyroid hormone receptor that may be selectively regulated by thyroid hormone could be important for the differential regulation of gene expression by T 3 in the pituitary gland.
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Citations
Cited by
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Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
A thyroid hormone receptor that is required for the development of green cone photoreceptors
Ng, L., Hurley, J. B., Dierks, B., Srinivas, M., Saltó, C., Vennström, B., Reh, T. A., & Forrest, D. (2001) · Nature Genetics · doi:10.1038/83829 · Cited by 561
Saravanan, P., Chau, W. ‐., Roberts, N., Vedhara, K., Greenwood, R., & Dayan, C. M. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01654.x · Cited by 514
Zelent, A., Mendelsohn, C., Kastner, P., Krust, A., Garnier, J. M., Ruffenach, F., Leroy, P., & Chambon, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07922.x · Cited by 379
Metadata
- Authors
- Hodin, R. A., Lazar, M. A., Wintman, B. I., Darling, D. S., Koenig, R. J., Larsen, P. R., Moore, D. D., & Chin, W. W.
- Venue
- Science
- Published
- 1989-04-07
- Volume
- 244
- Issue
- 4900
- Pages
- 76-79
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077580619
- Cited by
- 487
- References
- 0
- FWCI
- 34.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hodin, R. A., Lazar, M. A., Wintman, B. I., Darling, D. S., Koenig, R. J., Larsen, P. R., Moore, D. D., & Chin, W. W. (1989). Identification of a tHyroid Hormone Receptor That Is Pituitary-Specific. Science. https://doi.org/10.1126/science.2539642
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