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Studies of Inositol Phospholipid-Specific Phospholipase C
Open accessAbstract
Inositol phospholipid-specific phospholipase C is the enzyme that generates phosphoinositide-derived messenger molecules. Mammalian cells contain at least five immunologically distinct phospholipase C enzymes that appear to be separate gene products. Complete amino acid sequences of four of these isozymes have been established. The overall sequence similarity is surprisingly low for enzymes catalyzing the same chemical reaction: three of them show limited amino acid sequence similarity to each other in two narrow regions, and the fourth enzyme is completely different. The diversity in primary structure together with different regional and cellular expression of the isozymes suggests that each isozyme has a defined function in processing the physiological response of different cell types to a variety of external stimuli and that each is regulated differently.
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Citations
Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Regulation of Phosphoinositide-Specific Phospholipase C
Rhee, S. G. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.281 · Cited by 1,628
Self-citationMolecular cloning and expression of glycogen synthase kinase‐3/factor A.
Woodgett, J. R. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07419.x · Cited by 1,362
Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins
Taylor, S. J., Chae, H. Z., Rhee, S. G., & Exton, J. H. (1991) · Nature · doi:10.1038/350516a0 · Cited by 780
Self-citationXia, P., Aiello, L. P., Ishii, H., Jiang, Z. Y., Park, D. J., Robinson, G. S., Takagi, H., Newsome, W. P., Jirousek, M. R., & King, G. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119006 · Cited by 566
Phospholipase C families: Common themes and versatility in physiology and pathology
Katan, M., & Cockcroft, S. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101065 · Cited by 89
Ishiai, M., Sugawara, H., Kurosaki, M., & Kurosaki, T. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1746 · Cited by 71
Nishida, K., Yasuda, E., Nagasawa, K., & Fujimoto, S. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.857 · Cited by 21
Metadata
- Authors
- Rhee, S. G., Suh, P.-G., Ryu, S.-H., & Lee, S. Y.
- Venue
- Science
- Published
- 1989-05-05
- Volume
- 244
- Issue
- 4904
- Pages
- 546-550
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062748780
- Cited by
- 906
- References
- 0
- FWCI
- 47.61
- Type
- journal article
- Language
- en
- Open access
- green
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