The DOI matches its Crossref record.
Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor
Abstract
Basic fibroblast growth factor (bFGF) participates in many processes including early developmental events, angiogenesis, wound healing, and maintenance of neuronal cell viability. A 130-kilodalton protein was isolated on the basis of its ability to specifically bind to bFGF. A complementary DNA clone was isolated with an oligonucleotide probe corresponding to determined amino acid sequences of tryptic peptide fragments of the purified protein. The putative bFGF receptor encoded by this complementary DNA is a transmembrane protein that contains three extracellular immunoglobulin-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain. These domains are arranged in a pattern that is different from that of any growth factor receptor described.
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Citations
Cited by
Signal transduction by receptors with tyrosine kinase activity
Ullrich, A., & Schlessinger, J. (1990) · Cell · doi:10.1016/0092-8674(90)90801-k · Cited by 5,435
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation
Rapraeger, A. C., Krufka, A., & Olwin, B. B. (1991) · Science · doi:10.1126/science.1646484 · Cited by 1,508
Metadata
- Authors
- Lee, P. L., Johnson, D. E., Cousens, L. S., Fried, V. A., & Williams, L. T.
- Venue
- Science
- Published
- 1989-07-07
- Volume
- 245
- Issue
- 4913
- Pages
- 57-60
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036895735
- Cited by
- 648
- References
- 0
- FWCI
- 34.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, P. L., Johnson, D. E., Cousens, L. S., Fried, V. A., & Williams, L. T. (1989). Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor. Science. https://doi.org/10.1126/science.2544996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
