The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Human Diabetes Associated with a Mutation in the Tyrosine Kinase Domain of the Insulin Receptor
Abstract
Insulin receptor complementary DNA has been cloned from an insulin-resistant individual whose receptors have impaired tyrosine protein kinase activity. One of this individual's alleles has a mutation in which valine is substituted for Gly 996 , the third glycine in the conserved Gly-X-Gly-X-X-Gly motif in the putative binding site for adenosine triphosphate. Expression of the mutant receptor by transfection into Chinese hamster ovary cells confirmed that the mutation impairs tyrosine kinase activity.
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
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Caro, J. F., Ittoop, O., Pories, W. J., Meelheim, D., Flickinger, E. G., Thomas, F., Jenquin, M., Silverman, J. F., Khazanie, P. G., & Sinha, M. K. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112558 · Cited by 215
Cited by
Mutations of the BRAF gene in human cancer
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674
Structural Basis of Protein Kinase C Isoform Function
Steinberg, S. F. (2008) · Physiological Reviews · doi:10.1152/physrev.00034.2007 · Cited by 872
Coviello, A. D., Haring, R., Wellons, M., Vaidya, D., Lehtimäki, T., Keildson, S., Lunetta, K. L., He, C., Fornage, M., Lagou, V., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002805 · Cited by 250
Normal Insulin-Receptor cDNA Sequence in Pima Indians With NIDDM
Moller, D. E., Yokota, A., & Flier, J. S. (1989) · Diabetes · doi:10.2337/diab.38.11.1496 · Cited by 76
Structure and function of the insulin receptor-a personal perspective
KASUGA, M. (2019) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.95.039 · Cited by 15
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Metadata
- Authors
- Odawara, M., Kadowaki, T., Yamamoto, R., Shibasaki, Y., Tobe, K., Accili, D., Bevins, C., Mikami, Y., Matsuura, N., Akanuma, Y., Takaku, F., Taylor, S. I., & Kasuga, M.
- Venue
- Science
- Published
- 1989-07-07
- Volume
- 245
- Issue
- 4913
- Pages
- 66-68
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963847700
- Cited by
- 191
- References
- 4
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Odawara, M., Kadowaki, T., Yamamoto, R., Shibasaki, Y., Tobe, K., Accili, D., Bevins, C., Mikami, Y., Matsuura, N., Akanuma, Y., Takaku, F., Taylor, S. I., & Kasuga, M. (1989). Human Diabetes Associated with a Mutation in the Tyrosine Kinase Domain of the Insulin Receptor. Science. https://doi.org/10.1126/science.2544998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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