The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease
Abstract
A 47-kilodalton neutrophil cytosol factor (NCF-47k), required for activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase superoxide (O 2⋅ - ) production, is absent in most patients with autosomal recessive chronic granulomatous disease (AR-CGD). NCF-47k cDNAs were cloned from an expression library. The largest clone predicted a 41.9-kD protein that contained an arginine and serine-rich COOH-terminal domain with potential protein kinase C phosphorylation sites. A 33-amino acid segment of NCF-47k shared 49% identity with ras p21 guanosine triphosphatase activating protein. Recombinant NCF-47k restored O 2⋅ - -producing activity to AR-CGD neutrophil cytosol in a cell-free assay. Production of active recombinant NCF-47k will enable functional regions of this molecule to be mapped.
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Royer-Pokora, B., Kunkel, L. M., Monaco, A. P., Goff, S. C., Newburger, P. E., Baehner, R. L., Cole, F. S., Curnutte, J. T., & Orkin, S. H. (1986) · Nature · doi:10.1038/322032a0 · Cited by 833
Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease
Volpp, B. D., Nauseef, W. M., & Clark, R. A. (1988) · Science · doi:10.1126/science.2848318 · Cited by 407
Dinauer, M. C., Orkin, S. H., Brown, R., Jesaitis, A. J., & Parkos, C. A. (1987) · Nature · doi:10.1038/327717a0 · Cited by 407
Segal, A. W., Heyworth, P. G., Cockcroft, S., & Barrowman, M. M. (1985) · Nature · doi:10.1038/316547a0 · Cited by 281
Cited by
How human neutrophils kill and degrade microbes: an integrated view
Nauseef, W. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00550.x · Cited by 756
Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115929 · Cited by 686
p47phox is required for atherosclerotic lesion progression in ApoE–/– mice
Barry-Lane, P. A., Patterson, C., van der Merwe, M., Hu, Z., Holland, S. M., Yeh, E. T. H., & Runge, M. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111927 · Cited by 489
The p47phox mouse knock-out model of chronic granulomatous disease.
Jackson, S. H., Gallin, J. I., & Holland, S. M. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.751 · Cited by 484
Self-citationQuinn, M. T., & Gauss, K. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404216 · Cited by 480
Metadata
- Authors
- Lomax, K. J., Leto, T. L., Nunoi, H., Gallin, J. I., & Malech, H. L.
- Venue
- Science
- Published
- 1989-07-28
- Volume
- 245
- Issue
- 4916
- Pages
- 409-412
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050719029
- Cited by
- 333
- References
- 4
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lomax, K. J., Leto, T. L., Nunoi, H., Gallin, J. I., & Malech, H. L. (1989). Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease. Science. https://doi.org/10.1126/science.2547247
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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