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Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 -/- Mice
Abstract
Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)susceptible PL/J H-2 u through four backcross generations to investigate the role of CD8 + T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8 + T lymphocytes may participate as both effectors and regulators in this animal model.
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Cited by
Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.393 · Cited by 951
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis
Huseby, E. S., Liggitt, D., Brabb, T., Schnabel, B., Öhlén, C., & Goverman, J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.669 · Cited by 659
Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy
Shalapour, S., Font-Burgada, J., Di Caro, G., Zhong, Z., Sanchez-Lopez, E., Dhar, D., Willimsky, G., Ammirante, M., Strasner, A., Hansel, D. E., et al. (2015) · Nature · doi:10.1038/nature14395 · Cited by 611
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Shalapour, S., Lin, X.-J., Bastian, I. N., Brain, J., Burt, A. D., Aksenov, A. A., Vrbanac, A. F., Li, W., Perkins, A., Matsutani, T., et al. (2017) · Nature · doi:10.1038/nature24302 · Cited by 589
Metadata
- Authors
- Koh, D.-R., Fung-Leung, W.-P., Ho, A., Gray, D., Acha-Orbea, H., & Mak, T.-W.
- Venue
- Science
- Published
- 1992-05-22
- Volume
- 256
- Issue
- 5060
- Pages
- 1210-1213
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044465435
- Cited by
- 352
- References
- 0
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 -/- Mice. https://app.cochat.ai/papers/10.1126/science.256.5060.1210
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- Koh, D.-R., Fung-Leung, W.-P., Ho, A., Gray, D., Acha-Orbea, H., & Mak, T.-W. (1992). Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 -/- Mice. Science. https://doi.org/10.1126/science.256.5060.1210
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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