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Function of a Bacterial Activator Protein That Binds to Transcriptional Enhancers
Abstract
The nitrogen regulatory (NtrC) protein of enteric bacteria, which binds to sites that have the properties of transcriptional enhancers, is known to activate transcription by a form of RNA polymerase that contains the NtrA protein (σ 54 ) as sigma factor (referred to as σ 54 -holoenzyme). In the presence of adenosine triphosphate, the NtrC protein catalyzes isomerization of closed recognition complexes between σ 54 -holoenzyme and the glnA promoter to open complexes in which DNA in the region of the transcription start site is locally denatured. NtrC is not required subsequently for maintenance of open complexes or initiation of transcription.
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Citations
Cited by
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
Signal transduction schemes of bacteria
Parkinson, J. S. (1993) · Cell · doi:10.1016/0092-8674(93)90267-t · Cited by 772
Ptashne, M., & Gann, A. A. F. (1990) · Nature · doi:10.1038/346329a0 · Cited by 549
Control site location and transcriptional regulation in Escherichia coli
Collado‐Vides, J., Magasanik, B., & Gralla, J. D. (1991) · Microbiological Reviews · doi:10.1128/mmbr.55.3.371-394.1991 · Cited by 517
Bacterial Transcriptional Regulators for Degradation Pathways of Aromatic Compounds
Tropel, D., & van der Meer, J. R. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.3.474-500.2004 · Cited by 384
Metadata
- Authors
- Popham, D. L., Szeto, D., Keener, J., & Kustu, S.
- Venue
- Science
- Published
- 1989-02-03
- Volume
- 243
- Issue
- 4891
- Pages
- 629-635
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061918336
- Cited by
- 432
- References
- 0
- FWCI
- 23.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Popham, D. L., Szeto, D., Keener, J., & Kustu, S. (1989). Function of a Bacterial Activator Protein That Binds to Transcriptional Enhancers. Science. https://doi.org/10.1126/science.2563595
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