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The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging
Abstract
As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane-spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation.
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Citations
Cited by
Red cell membrane: past, present, and future
Mohandas, N., & Gallagher, P. G. (2008) · Blood · doi:10.1182/blood-2008-07-161166 · Cited by 1,089
Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging
Mohanty, J. G., Nagababu, E., & Rifkind, J. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00084 · Cited by 595
“However, the ability of the antioxidant system to neutralize the endogenous ROS is limited as the blood flows through the microcirculation and Hb becomes partially oxygenated.”
Background(1985) · PubMed · Cited by 346
An overview of molecular basis of iron metabolism regulation and the associated pathologies
Silva, B., & Faustino, P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.011 · Cited by 300
Macrophages and Systemic Iron Homeostasis
Ganz, T. (2012) · Journal of Innate Immunity · doi:10.1159/000336423 · Cited by 281
Metadata
- Authors
- Low, P. S., Waugh, S. M., Zinke, K., & Drenckhahn, D.
- Venue
- Science
- Published
- 1985-02
- Volume
- 227
- Issue
- 4686
- Pages
- 531-533
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044596656
- Cited by
- 395
- References
- 0
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging. https://app.cochat.ai/papers/10.1126/science.2578228
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- Low, P. S., Waugh, S. M., Zinke, K., & Drenckhahn, D. (1985). The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging. Science. https://doi.org/10.1126/science.2578228
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
