Cited by 300Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

An overview of molecular basis of iron metabolism regulation and the associated pathologies

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Silva, Bruno, Faustino, Paula·2015·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Abstract

Iron is essential for several vital biological processes. Its deficiency or overload drives to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, such as the alternative splicing, microRNAs, the IRP/IRE system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.

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Crossref · 10.1016/j.bbadis.2015.03.011

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  • The HIF and NRF2 pathways are related with anemia.

    “Furthermore, the hypoxia inducible factor (HIF) and the nuclear factor-erythroid 2-related factor 2 (NRF2) pathways are related with anemia (Lee et al., 2004;Silva and Faustino, 2015).”

    From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Silva and Faustino, 2015

    Section 4.1.4, “Anemia and erythropoiesis” (page unavailable), links anemia-related hypoxia to HIF-2 regulation of erythropoietin. Our copy does not establish the claimed NRF2–anemia relationship; searches for NRF2 and Nrf2 found no relevant passage. (LLM, conf=0.85)

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Authors
Silva, B., & Faustino, P.
Affiliations
National Institute of Health Dr. Ricardo Jorge (PT)
Corresponding author
Faustino, Paula
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher
Elsevier BV
Published
2015-07
Volume
1852
Issue
7
Pages
1347-1359
ISSN
0925-4439 (ISSN-L)
OpenAlex
W2076768785
Cited by
300
References
193
Citations by year
2026: 17 · 2025: 24 · 2024: 27 · 2023: 40 · 2022: 25 · 2021: 31 · 2020: 24 · 2019: 30 · 2018: 23 · 2017: 21 · 2016: 28 · 2015: 9 · 2012: 1
FWCI
4.04
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Funders
Fundação para a Ciência e a Tecnologia
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
iron metabolism, iron homeostasis, hepcidin, iron absorption, enterocytes, inflammation, anemia, erythropoiesis, post-transcriptional regulation, alternative splicing, microRNA, proteolytic cleavage
MeSH terms
Animals, Humans, Iron, Iron Metabolism Disorders, Iron-Binding Proteins, Iron-Regulatory Proteins

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