The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms
Abstract
The methylation state of DNA from human colon tissue displaying neoplastic growth was determined by means of restriction endonuclease analysis. When compared to DNA from adjacent normal tissue, DNA from both benign colon polyps and malignant carcinomas was substantially hypomethylated. With the use of probes for growth hormone, γ-globin, α-chorionic gonadotropin, and γ-crystallin, methylation changes were detected in all 23 neoplastic growths examined. Benign polyps were hypomethylated to a degree similar to that in malignant tissue. These results indicate that hypomethylation is a consistent biochemical characteristic of human colonic tumors and is an alteration in the DNA that precedes malignancy.
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Citations
Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Cited by
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
Self-citationGene Silencing in Cancer in Association with Promoter Hypermethylation
Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,422
Fraga, M. F., Ballestar, E., Villar-Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C., Ropero, S., Petrie, K., et al. (2005) · Nature Genetics · doi:10.1038/ng1531 · Cited by 1,923
Molecular Genetics of Colorectal Cancer
Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805
DNA methylation in cancer: too much, but also too little
Ehrlich, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205651 · Cited by 1,538
Metadata
- Authors
- Goelz, S. E., Vogelstein, B., Hamilton, S. R., & Feinberg, A. P.
- Venue
- Science
- Published
- 1985-04-12
- Volume
- 228
- Issue
- 4696
- Pages
- 187-190
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978419388
- Cited by
- 840
- References
- 1
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goelz, S. E., Vogelstein, B., Hamilton, S. R., & Feinberg, A. P. (1985). Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms. Science. https://doi.org/10.1126/science.2579435
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
