The DOI matches its Crossref record.
Identification of Human Glucocorticoid Receptor Complementary DNA Clones by Epitope Selection
Abstract
Steroid hormones regulate cellular differentiation and physiologic functions predominantly through gene transcription. Regulation is achieved by the interaction of specific steroid receptor proteins and target genes. Expression cloning techniques were used to select human glucocorticoid receptor complementary DNA clones in order to define the mechanism by which the receptor exerts its transcriptional control. Immobilized fusion proteins from individual clones were used to select epitope-specific antibody which was subsequently eluted and identified by binding to protein blots of cellular extracts. Three cross-hybridizing clones containing inserts expressing antigenic determinants of the human glucocorticoid receptor were isolated.
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Citations
Cited by
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590
Self-citationKamijo, K., Taketani, S., Yokota, S., Osumi, T., & Hashimoto, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39595-x · Cited by 391
Liver X receptors as regulators of macrophage inflammatory and metabolic pathways
A-González, N., & Castrillo, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.015 · Cited by 139
Allosteric Modulators of Steroid Hormone Receptors: Structural Dynamics and Gene Regulation
Kumar, R., & McEwan, I. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1033 · Cited by 135
Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms
CHARMANDARI, E., KINO, T., & CHROUSOS, G. P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.014 · Cited by 76
Metadata
- Authors
- Weinberger, C., Hollenberg, S. M., Ong, E. S., Harmon, J. M., Brower, S. T., Cidlowski, J., Thompson, E. B., Rosenfeld, M. G., & Evans, R. M.
- Venue
- Science
- Published
- 1985-05-10
- Volume
- 228
- Issue
- 4700
- Pages
- 740-742
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091550771
- Cited by
- 272
- References
- 0
- FWCI
- 21.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weinberger, C., Hollenberg, S. M., Ong, E. S., Harmon, J. M., Brower, S. T., Cidlowski, J., Thompson, E. B., Rosenfeld, M. G., & Evans, R. M. (1985). Identification of Human Glucocorticoid Receptor Complementary DNA Clones by Epitope Selection. Science. https://doi.org/10.1126/science.2581314
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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