The DOI matches its Crossref record.
Single Molecules Observed by Near-Field Scanning Optical Microscopy
Abstract
Individual carbocyanine dye molecules in a sub-monolayer spread have been imaged with near-field scanning optical microscopy. Molecules can be repeatedly detected and spatially localized (to ∼λ/50 where λ is the wavelength of light) with a sensitivity of at least 0.005 molecules/(Hz) 1/2 and the orientation of each molecular dipole can be determined. This information is exploited to map the electric field distribution in the near-field aperture with molecular spatial resolution.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Zero-Mode Waveguides for Single-Molecule Analysis at High Concentrations
Levene, M. J., Korlach, J., Turner, S. W., Foquet, M., Craighead, H. G., & Webb, W. W. (2003) · Science · doi:10.1126/science.1079700 · Cited by 1,378
Probing Individual Molecules with Confocal Fluorescence Microscopy
Nie, S., Chiu, D. T., & Zare, R. N. (1994) · Science · doi:10.1126/science.7973650 · Cited by 549
Bout, D. A. V., Yip, W.-T., Hu, D., Fu, D.-K., Swager, T. M., & Barbara, P. F. (1997) · Science · doi:10.1126/science.277.5329.1074 · Cited by 521
Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization
Forkey, J. N., Quinlan, M. E., Alexander Shaw, M., Corrie, J. E. T., & Goldman, Y. E. (2003) · Nature · doi:10.1038/nature01529 · Cited by 455
Image formation in near-field optics
Greffet, J.-J., & Carminati, R. (1997) · Progress in Surface Science · doi:10.1016/s0079-6816(98)00004-5 · Cited by 351
Metadata
- Authors
- Betzig, E., & Chichester, R. J.
- Venue
- Science
- Published
- 1993-11-26
- Volume
- 262
- Issue
- 5138
- Pages
- 1422-1425
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085189255
- Cited by
- 1,262
- References
- 0
- FWCI
- 57.86
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Single Molecules Observed by Near-Field Scanning Optical Microscopy. https://app.cochat.ai/papers/10.1126/science.262.5138.1422
- The paper
- Betzig, E., & Chichester, R. J. (1993). Single Molecules Observed by Near-Field Scanning Optical Microscopy. Science. https://doi.org/10.1126/science.262.5138.1422
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
