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Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β
Abstract
Human endothelial cells produced a neutrophil chemotactic factor (NCF) upon stimulation with tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), or lipopolysaccharide (LPS). The expression of endothelial cell-derived NCF messenger RNA and biological activity was both time- and concentration-dependent. Maximal NCF mRNA expression occurred at 10 and at 2 nanograms per milliliter for TNF and IL-1β, respectively; mRNA expression was first observed 1 hour after stimulation and was maintained for at least 24 hours. In situ hybridization analysis showed that NCF mRNA peaked in treated cells by 24 hours, whereas unstimulated cells were negative. These studies demonstrated that endothelial cells may participate in neutrophil-mediated inflammation by synthesizing a chemotactic factor in response to specific monokines and LPS.
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Citations
Cited by
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis
Strieter, R. M., Polverini, P. J., Kunkel, S. L., Arenberg, D. A., Burdick, M. D., Kasper, J., Dzuiba, J., Van Damme, J., Walz, A., Marriott, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27348 · Cited by 1,222
Self-citationCooke, K., Kobzik, L., Martin, T., Brewer, J., Delmonte, J. J., Crawford, J., & Ferrara, J. (1996) · Blood · doi:10.1182/blood.v88.8.3230.bloodjournal8883230 · Cited by 963
Colletti, L. M., Remick, D. G., Burtch, G. D., Kunkel, S. L., Strieter, R. M., & Campbell, D. A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114656 · Cited by 817
Self-citationThe role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
Brat, D. J., Bellail, A. C., & Van Meir, E. G. (2005) · Neuro-Oncology · doi:10.1215/s1152851704001061 · Cited by 760
Cytokine regulation of endothelial cell function
Mantovani, A., Bussolino, F., & Dejana, E. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.8.1592209 · Cited by 678
Metadata
- Authors
- Strieter, R. M., Kunkel, S. L., Showell, H. J., Remick, D. G., Phan, S. H., Ward, P. A., & Marks, R. M.
- Venue
- Science
- Published
- 1989-03-17
- Volume
- 243
- Issue
- 4897
- Pages
- 1467-1469
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072036820
- Cited by
- 775
- References
- 0
- FWCI
- 28.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β. https://app.cochat.ai/papers/10.1126/science.2648570
- The paper
- Strieter, R. M., Kunkel, S. L., Showell, H. J., Remick, D. G., Phan, S. H., Ward, P. A., & Marks, R. M. (1989). Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β. Science. https://doi.org/10.1126/science.2648570
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