The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease
Abstract
The prohormone-processing endoprotease ( KEX2 gene product) of the yeast Saccharomyces cerevisiae is a membrane-bound, 135,000-dalton glycoprotein, which contains both asparagine-linked and serine- and threonine-linked oligosaccharide and resides in a secretory compartment. Analysis of mutant kex2 genes truncated at their 3′ end indicates that carboxyl terminal domains of the enzyme are required for its proper localization within the cell. A human gene product, "furin," shares 50% identity with the catalytic domain of Kex2 protease and is, therefore, a candidate for a human prohormone-processing enzyme.
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Cites
Structural relationships between clathrin assembly proteins from the Golgi and the plasma membrane.
Ahle, S., Mann, A., Eichelsbacher, U., & Ungewickell, E. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02897.x · Cited by 354
Cited by
SEIDAH, N. G., GASPAR, L., MION, P., MARCINKIEWICZ, M., MBIKAY, M., & CHRÉTIEN, M. (1990) · DNA and Cell Biology · doi:10.1089/dna.1990.9.415 · Cited by 512
Host cell proteases controlling virus pathogenicity
Klenk, H.-D., & Garten, W. (1994) · Trends in Microbiology · doi:10.1016/0966-842x(94)90123-6 · Cited by 466
Stirling, C. J., Rothblatt, J., Hosobuchi, M., Deshaies, R., & Schekman, R. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.2.129 · Cited by 349
Engineering of protein secretion in yeast: strategies and impact on protein production
Idiris, A., Tohda, H., Kumagai, H., & Takegawa, K. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2447-0 · Cited by 324
Dohlman, H. G., Song, J., Ma, D., Courchesne, W. E., & Thorner, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.5194 · Cited by 323
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Metadata
- Authors
- Fuller, R. S., Brake, A. J., & Thorner, J.
- Venue
- Science
- Published
- 1989-10-27
- Volume
- 246
- Issue
- 4929
- Pages
- 482-486
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012020894
- Cited by
- 395
- References
- 1
- FWCI
- 14.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fuller, R. S., Brake, A. J., & Thorner, J. (1989). Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease. Science. https://doi.org/10.1126/science.2683070
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
