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Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response
Abstract
During stress, the activity of the sympathetic nervous system is changed in a global fashion, leading to an increase in cardiovascular function and a release of adrenal catecholamines. This response is thought to be regulated by a common set of brain neurons that provide a dual input to the sympathetic preganglionic neurons regulating cardiac and adrenal medullary functions. By using a double-virus transneuronal labeling technique, the existence of such a set of central autonomic neurons in the hypothalamus and brainstem was demonstrated. These neurons innervate both of the sympathetic outflow systems and likely function in circumstances where parallel sympathetic processing occurs, such as in the fight-or-flight response.
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Citations
Cited by
The sympathetic control of blood pressure
Guyenet, P. G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1902 · Cited by 1,863
The central autonomic nervous system: conscious visceral perception and autonomic pattern generation
Saper, C. B. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.032502.111311 · Cited by 837
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 699
Radley, J. J., Arias, C. M., & Sawchenko, P. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4297-06.2006 · Cited by 456
CNS origins of the sympathetic nervous system outflow to brown adipose tissue
Bamshad, M., Song, C. K., & Bartness, T. J. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.6.r1569 · Cited by 437
Metadata
- Authors
- Jansen, A. S. P., Van Nguyen, X., Karpitskiy, V., Mettenleiter, T. C., & Loewy, A. D.
- Venue
- Science
- Published
- 1995-10-27
- Volume
- 270
- Issue
- 5236
- Pages
- 644-646
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2118406111
- Cited by
- 729
- References
- 0
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response. https://app.cochat.ai/papers/10.1126/science.270.5236.644
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- Jansen, A. S. P., Van Nguyen, X., Karpitskiy, V., Mettenleiter, T. C., & Loewy, A. D. (1995). Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response. Science. https://doi.org/10.1126/science.270.5236.644
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
