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Regulation of PHO4 Nuclear Localization by the PHO80-PHO85 Cyclin-CDK Complex
Abstract
PHO4, a transcription factor required for induction of the PHO5 gene in response to phosphate starvation, is phosphorylated by the PHO80-PHO85 cyclin-CDK (cyclin-dependent kinase) complex when yeast are grown in phosphate-rich medium. PHO4 was shown to be concentrated in the nucleus when yeast were starved for phosphate and was predominantly cytoplasmic when yeast were grown in phosphate-rich medium. The sites of phosphorylation on PHO4 were identified, and phosphorylation was shown to be required for full repression of PHO5 transcription when yeast were grown in high phosphate. Thus, phosphorylation of PHO4 by PHO80-PHO85 turns off PHO5 transcription by regulating the nuclear localization of PHO4.
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Citations
Cited by
Nucleocytoplasmic transport: the soluble phase
Mattaj, I. W., & Englmeier, L. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.265 · Cited by 1,175
Brunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A., & Greenberg, M. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.3.952-965.2001 · Cited by 860
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
Nash, P., Tang, X., Orlicky, S., Chen, Q., Gertler, F. B., Mendenhall, M. D., Sicheri, F., Pawson, T., & Tyers, M. (2001) · Nature · doi:10.1038/35107009 · Cited by 759
Defining mechanisms that regulate RNA polymerase II transcription in vivo
Fuda, N. J., Ardehali, M. B., & Lis, J. T. (2009) · Nature · doi:10.1038/nature08449 · Cited by 576
Molecular mechanisms of phosphate transport in plants
Rausch, C., & Bucher, M. (2002) · Planta · doi:10.1007/s00425-002-0921-3 · Cited by 522
Metadata
- Authors
- O'Neill, E. M., Kaffman, A., Jolly, E. R., & O'Shea, E. K.
- Venue
- Science
- Published
- 1996-01-12
- Volume
- 271
- Issue
- 5246
- Pages
- 209-212
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993366229
- Cited by
- 330
- References
- 0
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- O'Neill, E. M., Kaffman, A., Jolly, E. R., & O'Shea, E. K. (1996). Regulation of PHO4 Nuclear Localization by the PHO80-PHO85 Cyclin-CDK Complex. Science. https://doi.org/10.1126/science.271.5246.209
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
