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Nucleocytoplasmic Transport

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Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

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Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

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Isolation of a protein that is essential for the first step of nuclear protein import

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The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

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SR proteins and splicing control.Preprint

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A Novel Receptor-Mediated Nuclear Protein Import Pathway

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Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α

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The SMN–SIP1 Complex Has an Essential Role in Spliceosomal snRNP Biogenesis

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The Spinal Muscular Atrophy Disease Gene Product, SMN, and Its Associated Protein SIP1 Are in a Complex with Spliceosomal snRNP Proteins

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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

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Identification of different roles for RanGDP and RanGTP in nuclear protein import.

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The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

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Export of Importin α from the Nucleus Is Mediated by a Specific Nuclear Transport Factor

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A polypeptide domain that specifies migration of nucleoplasmin into the nucleus

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Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

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Protein Import into the Cell Nucleus

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Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

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Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores

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A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway

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Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

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Regulation by HIV Rev depends upon recognition of splice sites

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Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region

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The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

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The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

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Distinct functions for the two importin subunits in nuclear protein import

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Synthetic peptides as nuclear localization signals

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Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

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The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

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A small element from the Mason-Pfizer monkey virusgenome makes human immunodeficiency virus type 1 expression and replicationRev-independent.

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A Novel Class of RanGTP Binding Proteins

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A 41 amino acid motif in importin‐alpha confers binding to importin‐beta and hence transit into the nucleus.

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Monomethylated cap structures facilitate RNA export from the nucleus

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Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

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Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.

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Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

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Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding

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Sequence-specific RNA binding by the HIV-1 Rev protein

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Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit

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THE NUCLEAR PORE COMPLEX

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Targeting of E. coli β-galactosidase to the nucleus in yeast

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Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.Preprint

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The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

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The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA.

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Nucleocytoplasmic Transport: The Last 200 Nanometers

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A Distinct Nuclear Import Pathway Used by Ribosomal Proteins

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The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.

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Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs

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Sequential Binding of Import Ligands to Distinct Nucleopore Regions During Their Nuclear Import

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Nuclear import of U snRNPs requires importin β

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A cellular cofactor for the constitutive transport element of type D retrovirus

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Differential Binding of Heterogeneous Nuclear Ribonucleoproteins to mRNA Precursors prior to Spliceosome Assembly In Vitro

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LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

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A Conserved mRNA Export Machinery Coupled to pre-mRNA Splicing

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The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP

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Nuclear Import of the Glucocorticoid Receptor-hsp90 Complex through the Nuclear Pore Complex Is Mediated by Its Interaction with Nup62 and Importin β

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Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding

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Nup153 unlocks the nuclear pore complex for HIV-1 nuclear translocation in nondividing cells

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tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes

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UV-Induced Nuclear Import of XPA Is Mediated by Importin-α4 in An ATR-Dependent Manner

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The Mechanism of Ran Import into the Nucleus by Nuclear Transport Factor 2

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The Crystal Structure of the Ran-Nup153ZnF2 Complex: a General Ran Docking Site at the Nuclear Pore Complex

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Nuclear Transport

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A Monoclonal Antibody to the COOH-terminal Acidic Portion of Ran Inhibits Both the Recycling of Ran and Nuclear Protein Import in Living Cells

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Functional analysis of the yeast Ran exchange factor Prp20p: in vivo evidence for the RanGTP gradient model

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