The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Plasmodium Hemozoin Formation Mediated by Histidine-Rich Proteins
Abstract
The digestive vacuole of Plasmodium falciparum is the site of hemoglobin degradation, heme polymerization into crystalline hemozoin, and antimalarial drug accumulation. Antibodies identified histidine-rich protein II (HRP II) in purified digestive vacuoles. Recombinant or native HRP II promoted the formation of hemozoin, and chloroquine inhibited the reaction. The related HRP III also polymerized heme, and an additional HRP was identified in vacuoles. It is proposed that after secretion by the parasite into the host erythrocyte cytosol, HRPs are brought into the acidic digestive vacuole along with hemoglobin. After hemoglobin proteolysis, HRPs bind the liberated heme and mediate hemozoin formation.
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Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
Smith, J. D., Chitnis, C. E., Craig, A. G., Roberts, D. J., Hudson-Taylor, D. E., Peterson, D. S., Pinches, R., Newbold, C. I., & Miller, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90056-x · Cited by 1,005
Cited by
Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2
Dondorp, A. M., Desakorn, V., Pongtavornpinyo, W., Sahassananda, D., Silamut, K., Chotivanich, K., Newton, P. N., Pitisuttithum, P., Smithyman, A. M., White, N. J., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020204 · Cited by 448
The evolution, metabolism and functions of the apicoplast
Lim, L., & McFadden, G. I. (2010) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2009.0273 · Cited by 356
HDP—A Novel Heme Detoxification Protein from the Malaria Parasite
Jani, D., Nagarkatti, R., Beatty, W., Angel, R., Slebodnick, C., Andersen, J., Kumar, S., & Rathore, D. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000053 · Cited by 166
The Peculiarities and Paradoxes of Plasmodium Heme Metabolism
Sigala, P. A., & Goldberg, D. E. (2014) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091313-103537 · Cited by 129
Self-citationHaemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator
Hänscheid, T., Egan, T. J., & Grobusch, M. P. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70238-4 · Cited by 128
Metadata
- Authors
- Sullivan, D. J., Gluzman, I. Y., & Goldberg, D. E.
- Venue
- Science
- Published
- 1996-01-12
- Volume
- 271
- Issue
- 5246
- Pages
- 219-222
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006250595
- Cited by
- 436
- References
- 2
- FWCI
- 26.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sullivan, D. J., Gluzman, I. Y., & Goldberg, D. E. (1996). Plasmodium Hemozoin Formation Mediated by Histidine-Rich Proteins. Science. https://doi.org/10.1126/science.271.5246.219
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