The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
Abstract
About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4 , a gene similar in sequence to a Drosophila melanogaster gene ( Mad ) implicated in a transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.
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“SMAD4 is a tumor suppressor gene, and reported results about the prognostic value of SMAD4 have been inconsistent39,60–62.”
From Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma (2024) · cites this paper as [60]
In the citing paper
“SMAD4 is a tumor suppressor gene, and reported results about the prognostic value of SMAD4 have been inconsistent39,60–62.”
From Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma (2024) · cites this paper as [60]
Citations
Cites
A cell cycle regulator potentially involved in genesis of many tumor types
Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,765
Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton, S. R., Preisinger, A. C., Thomas, G., Kinzler, K. W., et al. (1990) · Science · doi:10.1126/science.2294591 · Cited by 1,760
Self-citationThe Molecular Genetics of Cancer
Bishop, J. M. (1987) · Science · doi:10.1126/science.3541204 · Cited by 1,674
Hereditary cancer, oncogenes, and antioncogenes.
Knudson, A. G. (1985) · PubMed · Cited by 1,218
Liu, Y., & Whittier, R. F. (1995) · Genomics · doi:10.1016/0888-7543(95)80010-j · Cited by 1,141
Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M. E. M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., & Kern, S. E. (1994) · Nature Genetics · doi:10.1038/ng0994-27 · Cited by 1,132
Self-citationSekelsky, J. J., Newfeld, S. J., Raftery, L. A., Chartoff, E. H., & Gelbart, W. M. (1995) · Genetics · doi:10.1093/genetics/139.3.1347 · Cited by 659
Hruban, R. H., van Mansfeld, A. D. M., Offerhaus, G. J. A., van Weering, D. H. J., Allison, D. C., Goodman, S. N., Kensler, T. W., Bose, K., Cameron, J. L., & Bos, J. L. (1993) · PubMed Central · Cited by 650
Self-citationMolecular Diagnosis of Familial Adenomatous Polyposis
Powell, S. M., Petersen, G. M., Krush, A. J., Booker, S. V., Jen, J., Giardiello, F. M., Hamilton, S. R., Vogelstein, B., & Kinzler, K. W. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292702 · Cited by 600
Redston, M. S., Caldas, C., Seymour, A. B., Hruban, R. H., da Costa, L., Yeo, C. J., & Kern, S. E. (1994) · PubMed · Cited by 451
Self-citationA first-generation physical map of the human genome
Cohen, D., Chumakov, I. M., & Weissenbach, J. (1993) · Nature · doi:10.1038/366698a0 · Cited by 443
Transforming growth factor beta and cell cycle regulation.
Alexandrow, M. G., & Moses, H. L. (1995) · PubMed · Cited by 363
Allelotype of pancreatic adenocarcinoma using xenograft enrichment.
Hahn, S. A., Ab, S., Hoque, A. T., Schutte, M. E. M., da Costa, L. T., Redston, M. S., Caldas, C., Weinstein, C. L., Fischer, A., & Yeo, C. J. (1995) · PubMed · Cited by 310
Self-citationGoyette, M., Cho, K. R., Fasching, C. L., Levy, D. B., Kinzler, K. W., Paraskeva, C., Vogelstein, B., & Stanbridge, E. J. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.1387 · Cited by 242
Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas.
Dryja, T. P., Rapaport, J. M., Joyce, J. M., & Petersen, R. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7391 · Cited by 239
The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas
Cho, K. R., Oliner, J. D., Simons, J. W., Hedrick, L., Fearon, E. R., Preisinger, A. C., Hedge, P., Silverman, G. A., & Vogelstein, B. (1994) · Genomics · doi:10.1006/geno.1994.1102 · Cited by 224
Schutte, M. E. M., da Costa, L. T., Hahn, S. A., Moskaluk, C. A., Hoque, A. T. M. S., Rozenblum, E., Weinstein, C. L., Bittner, M. L., Meltzer, P. S., & Trent, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5950 · Cited by 163
Self-citationHursh, D. A., Padgett, R. W., & Gelbart, W. M. (1993) · Development · doi:10.1242/dev.117.4.1211 · Cited by 115
Goyette, M., Cho, K. R., Fasching, C. L., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.3.1387-1395.1992 · Cited by 64
Isolating vector-insert junctions from yeast artificial chromosomes.Preprint
Silverman, G. A. (1993) · Genome Research · doi:10.1101/gr.3.3.141 · Cited by 18
A radiation hybrid map of human chromosome 18
Francke, U., Chang, E., Comeau, K., Geigl, E.-M., Giacalone, J. C., Li, X., Luna, J., Moon, A., Welch, S. K., & Wilgenbus, P. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133697 · Cited by 11
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- LEACH S. F., COMMUNICATION .
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Sorted by citations
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697
Role of Transforming Growth Factor β in Human Disease
Blobe, G. C., Schiemann, W. P., & Lodish, H. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421807 · Cited by 2,453
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,391
Metadata
- Authors
- Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., & Kern, S. E.
- Affiliations
- Johns Hopkins University (US)
- S. A. Hahn, M. Schutte, A. T. M. S. Hoque, C. A. Moskaluk, E. Rozenblum, C. L. Weinstein, A. Fischer, R. H. Hruban, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- L. T. da Costa, Graduate Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- Corresponding author
- Kern, Scott E.
- ORCID
- Venue
- Science
- Published
- 1996-01-19
- Volume
- 271
- Issue
- 5247
- Pages
- 350-353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2100522747
- Cited by
- 2,337
- References
- 25
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 29 · 2023: 26 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 44 · 2018: 41 · 2017: 46 · 2016: 55 · 2015: 59 · 2014: 71 · 2013: 64 · 2012: 67
- FWCI
- 70.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (P50CA062924, CA 62924)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- SMAD4, tumor suppressor, pancreatic cancer, homozygous deletion, loss of heterozygosity, TGF-beta signaling, loss-of-function mutations, candidate gene identification
- MeSH terms
- Alleles, Amino Acid Sequence, Animals, Base Sequence, Cell Division, Chromosome Mapping, Chromosomes, Human, Pair 18, DNA-Binding Proteins, Genetic Markers, Humans, Molecular Sequence Data, Mutation, Neoplasm Transplantation, Pancreatic Neoplasms, Proteins, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Trans-Activators, Gene Expression, Genes, Tumor Suppressor, Transforming Growth Factor beta, Gene Deletion, Mice, Smad4 Protein
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