Cited by 2,337Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancerCancer-related Molecular Pathways

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Hahn, Stephan A., Schutte, Mieke, Shamsul Hoque, A. T. M., Moskaluk, Christopher A., da Costa, Luis T., Rozenblum, Ester, Weinstein, Craig L., Fischer, Aryeh, Yeo, Charles J., Hruban, Ralph H., Kern, Scott E.·1996·Science

DOI 10.1126/science.271.5247.350

Open this paper in CoChat — free account

Abstract

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4 , a gene similar in sequence to a Drosophila melanogaster gene ( Mad ) implicated in a transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.

Integrity signals

Registry

Crossref · 10.1126/science.271.5247.350

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A cell cycle regulator potentially involved in genesis of many tumor types
Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950
Tumor Suppressor Genes
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,765
Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton, S. R., Preisinger, A. C., Thomas, G., Kinzler, K. W., et al. (1990) · Science · doi:10.1126/science.2294591 · Cited by 1,760
Self-citation
The Molecular Genetics of Cancer
Bishop, J. M. (1987) · Science · doi:10.1126/science.3541204 · Cited by 1,674
Hereditary cancer, oncogenes, and antioncogenes.
Knudson, A. G. (1985) · PubMed · Cited by 1,218
Thermal asymmetric interlaced PCR: automatable amplification and sequencing of insert end fragments from P1 and YAC clones for chromosome walking
Liu, Y., & Whittier, R. F. (1995) · Genomics · doi:10.1016/0888-7543(95)80010-j · Cited by 1,141
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M. E. M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., & Kern, S. E. (1994) · Nature Genetics · doi:10.1038/ng0994-27 · Cited by 1,132
Self-citation

Show all 25 references

Research works printed but not linked: 2

HAHN A. S., IN PRESS CANCER RES .
LEACH S. F., COMMUNICATION .

Sorted by citations

TGF-β SIGNAL TRANSDUCTION
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697
Role of Transforming Growth Factor β in Human Disease
Blobe, G. C., Schiemann, W. P., & Lodish, H. F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421807 · Cited by 2,453
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,391
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Hahn, H., Wicking, C., Zaphiropoulos, P. G., Gailani, M. R., Shanley, S., Chidambaram, A., Vořechovský, I., Holmberg, E., Undén, A. B., Gillies, S. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81268-4 · Cited by 2,018
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Preprint
Hogan, B. L. M. (1996) · Genes & Development · doi:10.1101/gad.10.13.1580 · Cited by 1,964
How cells read TGF-β signals
Massagué, J. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043051 · Cited by 1,925
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
Johnson, R. L., Rothman, A., Xie, J., Goodrich, L. V., Bare, J. W., Bonifas, J. M., Quinn, A., Myers, R., Cox, D., Epstein, E. H., et al. (1996) · Science · doi:10.1126/science.272.5268.1668 · Cited by 1,856
Pancreatic cancer
Li, D., Xie, K., Wolff, R. A., & Abbruzzese, J. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15841-8 · Cited by 1,731
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
Siegel, P. M., & Massagué, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1208 · Cited by 1,626
Genetics and biology of pancreatic ductal adenocarcinomaPreprint
Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N. M., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,611
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y., Grinnell, B. W., Richardson, M. A., Topper, J. N., Gimbrone, M. A., Wrana, J. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80303-7 · Cited by 1,322
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
TGF-β signaling in health, disease and therapeutics
Deng, Z., Fan, T. T., Chu, X., Tian, H., Zheng, Y., Li, C., & He, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01764-w · Cited by 1,360
TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
Hao, Y., Baker, D. A., & ten Dijke, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112767 · Cited by 1,196
Pancreatic cancer biology and genetics
Bardeesy, N. M., & DePinho, R. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc949 · Cited by 1,176
TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4
Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C., Miyazono, K., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5353 · Cited by 1,071
A Gene Map of the Human Genome
Schuler, G. D., Boguski, M. S., Stewart, E. A., Stein, L. D., Gyapay, G., Rice, K., White, R. E., Rodriguez‐Tomé, P., Aggarwal, A., Bajorek, E. S., et al. (1996) · Science · doi:10.1126/science.274.5287.540 · Cited by 1,044
Principles of Tumor Suppression
Sherr, C. J. (2004) · Cell · doi:10.1016/s0092-8674(03)01075-4 · Cited by 1,028
A mechanism of repression of TGFbeta / Smad signaling by oncogenic RasPreprint
Kretzschmar, M., Doody, J. F., Timokhina, I., & Massagué, J. (1999) · Genes & Development · doi:10.1101/gad.13.7.804 · Cited by 997
Bone morphogenetic protein receptors and signal transduction
Miyazono, K., Kamiya, Y., & Morikawa, M. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp148 · Cited by 1,000
TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
Yin, J. J., Selander, K. S., Chirgwin, J. M., Dallas, M., Grubbs, B. G., Wieser, R., Massagué, J., Mundy, G. R., & Guise, T. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3523 · Cited by 988
Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators
Zawel, L. S., Dai, J. L., Buckhaults, P., Zhou, S., Kinzler, K. W., Vogelstein, B., & Kern, S. E. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80061-1 · Cited by 940
Self-citation
APC, Signal transduction and genetic instability in colorectal cancer
Fodde, R., Smits, R., & Clevers, H. (2001) · Nature Reviews Cancer · doi:10.1038/35094067 · Cited by 937
Phenotype and Genotype of Pancreatic Cancer Cell Lines
Deer, E. L., González-Hernández, J., Coursen, J. D., Shea, J. E., Ngatia, J., Scaife, C. L., Firpo, M. A., & Mulvihill, S. J. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181c15963 · Cited by 936
Recent progress in pancreatic cancer
Wolfgang, C. L., Herman, J. M., Laheru, D. A., Klein, A. P., Erdek, M. A., Fishman, E. K., & Hruban, R. H. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21190 · Cited by 935
Self-citation
Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis
Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Järvinen, H., Sistonen, P., Tomlinson, I. P. M., Houlston, R. S., Bevan, S., Mitros, F. A., et al. (1998) · Science · doi:10.1126/science.280.5366.1086 · Cited by 908
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
Lagna, G., Hata, A., Hemmati‐Brivanlou, A., & Massagué, J. (1996) · Nature · doi:10.1038/383832a0 · Cited by 905
TGF-β signaling in health and disease
Massagué, J., & Sheppard, D. (2023) · Cell · doi:10.1016/j.cell.2023.07.036 · Cited by 890
Colorectal Cancer: Molecules and Populations
Potter, J. D. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.11.916 · Cited by 876
Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
Kretzschmar, M., Doody, J. F., & Massagué, J. (1997) · Nature · doi:10.1038/39348 · Cited by 878
Receptor-associated Mad homologues synergize as effectors of the TGF-β response
Zhang, Y. E., Feng, X., Wu, R.-Y., & Derynck, R. (1996) · Nature · doi:10.1038/383168a0 · Cited by 873
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment
Wood, L. D., Canto, M. I., Jaffee, E. M., & Simeone, D. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.03.056 · Cited by 918
Contextual determinants of TGFβ action in development, immunity and cancer
David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
Eppert, K., Scherer, S. W., Özçelik, H., Pirone, R., Hoodless, P. A., Kim, H., Tsui, L.-C., Bapat, B. V., Gallinger, S., Andrulis, I. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80128-2 · Cited by 845
TGFβ Signaling: Receptors, Transducers, and Mad Proteins
Massagué, J. (1996) · Cell · doi:10.1016/s0092-8674(00)81296-9 · Cited by 836
Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily
Chang, H., Brown, C., & Matzuk, M. M. (2002) · Endocrine Reviews · doi:10.1210/er.2002-0003 · Cited by 795
Specificity, diversity, and regulation in TGF-beta superfamily signaling.
Piek, E., HELDIN, C., & ten Dijke, P. (1999) · PubMed · Cited by 783
Epithelial-mesenchymal transition in cancer development and its clinical significance
Iwatsuki, M., Mimori, K., Yokobori, T., Ishi, H., Beppu, T., Nakamori, S., Baba, H., & Mori, M. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2009.01419.x · Cited by 780
Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene
Fazeli, A., Dickinson, S., Hermiston, M. L., Tighe, R., Steen, R. G., Small, C. G., Stoeckli, E. T., Keino‐Masu, K., Masu, M., Rayburn, H., et al. (1997) · Nature · doi:10.1038/386796a0 · Cited by 778
The colorectal adenoma–carcinoma sequence
Leslie, A., CAREY, F. A., Pratt, N. R., & Steele, R. J. (2002) · British journal of surgery · doi:10.1046/j.1365-2168.2002.02120.x · Cited by 771
MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling
Macías‐Silva, M., Abdollah, S., Hoodless, P. A., Pirone, R., Attisano, L., & Wrana, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81817-6 · Cited by 735
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressorPreprint
Hata, A., Lagna, G., Massagué, J., & Hemmati‐Brivanlou, A. (1998) · Genes & Development · doi:10.1101/gad.12.2.186 · Cited by 726
Bone morphogenetic proteins in development
Hogan, B. L. M. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80064-5 · Cited by 715
Role of Transforming Growth Factor Beta in Human Cancer
Elliott, R. L., & Blobe, G. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.02.047 · Cited by 717
Pancreatic Cancer
Maitra, A., & Hruban, R. H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154305 · Cited by 707
Self-citation
MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
Hoodless, P. A., Haerry, T. E., Abdollah, S., Stapleton, M., O’Connor, M. B., Attisano, L., & Wrana, J. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81250-7 · Cited by 698
Bone morphogenetic proteins in development
Šimić, P., & Vukičević, S. (2004) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7857-9_4 · Cited by 674
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
Bardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674
A human Mad protein acting as a BMP-regulated transcriptional activator
Liu, F., Hata, A., Baker, J. C., Doody, J. F., Cárcamo, J. M., Harland, R. M., & Massagué, J. (1996) · Nature · doi:10.1038/381620a0 · Cited by 673
Two major Smad pathways in TGF‐β superfamily signalling
Miyazawa, K., Shinozaki, M., Hara, T., Furuya, T., & Miyazono, K. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00599.x · Cited by 672
TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?
Martin, M. T., Lefaix, J.-L., & Delanian, S. E. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)00435-1 · Cited by 659
Specificity, diversity, and regulation in TGF‐β superfamily signaling
Piek, E., Heldin, C., & ten Dijke, P. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2105 · Cited by 837
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.
Goggins, M., Schutte, M. E. M., Lü, J., Moskaluk, C. A., Weinstein, C. L., Petersen, G. M., Yeo, C. J., Jackson, C. E., Lynch, H. T., Hruban, R. H., et al. (1996) · PubMed · Cited by 642
Self-citation
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
Wang, W., Abbruzzese, J. L., Evans, D. B., Larry, L., Cleary, K. R., & Chiao, P. J. (1999) · PubMed · Cited by 640
Transforming growth factor βs and wound healing
O’Kane, S., & Ferguson, M. W. J. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(96)00120-3 · Cited by 634
The role of TGF-β/SMAD4 signaling in cancer
Zhao, M., Mishra, L., & Deng, C.-X. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.23230 · Cited by 631
TGF-β Family Signaling in the Control of Cell Proliferation and Survival
Zhang, Y., Alexander, P. B., & Wang, X.-F. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022145 · Cited by 626
TGF-β signaling by Smad proteins
Miyazono, K. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(99)00025-8 · Cited by 627
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
Thiagalingam, S., Christoph Lengauer, C., Leach, F. S., Schutte, M. E. M., Hahn, S. A., Overhauser, J., Willson, J. K. V., Markowitz, S. D., Hamilton, S. R., Kern, S. E., et al. (1996) · Nature Genetics · doi:10.1038/ng0796-343 · Cited by 616
Self-citation
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
Wang, R.-H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.010 · Cited by 614
Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes
Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F., & Taketo, M. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81132-0 · Cited by 616
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
Mahadevan, D., & Hoff, D. D. V. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0686 · Cited by 619
TGF-β Tumor Suppression through a Lethal EMT
David, C. J., Huang, Y.-H., Chen, M., Su, J., Zou, Y., Bardeesy, N. M., Iacobuzio–Donahue, C. A., & Massagué, J. (2016) · Cell · doi:10.1016/j.cell.2016.01.009 · Cited by 597
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.
Wilentz, R. E., Iacobuzio–Donahue, C. A., Argani, P., McCarthy, D. M., Parsons, J. L., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · PubMed · Cited by 591
Self-citation
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
Kretzschmar, M., Liu, F., Hata, A., Doody, J., & Massagué, J. (1997) · Genes & Development · doi:10.1101/gad.11.8.984 · Cited by 574
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Morris, J. P., Wang, S. C., & Hebrok, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2899 · Cited by 597
Polycomb group proteins: navigators of lineage pathways led astray in cancer
Bracken, A. P., & Helin, K. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2736 · Cited by 523
A Smad Transcriptional Corepressor
Wotton, D., Lo, R. S., Lee, S., & Massagué, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80712-6 · Cited by 554
Stromal biology and therapy in pancreatic cancer: a changing paradigm
Neeße, A., Algül, H., Tuveson, D. A., & Gress, T. M. (2015) · Gut · doi:10.1136/gutjnl-2015-309304 · Cited by 567
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
Lahn, M. M. F., Herbertz, S., Sawyer, J. S., Stauber, A. J., Gueorguieva, I., Driscoll, K. E., Estrem, S. T., Cleverly, A., Desaiah, D., Guba, S. C., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s86621 · Cited by 571
Oncoprotein Networks
Hunter, T. R. (1997) · Cell · doi:10.1016/s0092-8674(00)81872-3 · Cited by 553
KLF4, p21 and context-dependent opposing forces in cancer
Rowland, B. D., & Peeper, D. S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1780 · Cited by 566
Alterations in components of the TGF-β superfamily signaling pathways in human cancer
LEVY, L., & HILL, C. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.09.009 · Cited by 539
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
Lerman, M. I., & Minna, J. D. (2000) · PubMed · Cited by 537
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
Pardali, K., & Moustakas, A. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.06.004 · Cited by 549
Signaling of transforming growth factor‐β family members through Smad proteins
Itoh, S., Itoh, F., Goumans, M., & ten Dijke, P. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01828.x · Cited by 537
Signal transduction by bone morphogenetic proteins
Kawabata, M. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00036-1 · Cited by 530
Role of Transforming Growth Factor-beta Signaling in Cancer
de Caestecker, M. P. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.17.1388 · Cited by 521
Landscaping the Cancer Terrain
Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.280.5366.1036 · Cited by 519
Addressing the challenges of pancreatic cancer: Future directions for improving outcomes
Hidalgo, M. M., Cascinu, S., Kleeff, J. H., Labianca, R., Löhr, M. J., Neoptolemos, J. P., Real, F. X., Laethem, J. V., & Heinemann, V. (2014) · Pancreatology · doi:10.1016/j.pan.2014.10.001 · Cited by 530
TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300Preprint
Janknecht, R., Wells, N. J., & Hunter, T. R. (1998) · Genes & Development · doi:10.1101/gad.12.14.2114 · Cited by 511
SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes
Verschueren, K., Remacle, J., Collart, C., Kraft, H. J., Baker, B. S., Tylżanowski, P., Nelles, L., Wuytens, G., Su, M., Bodmer, R., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20489 · Cited by 513
Divergence and convergence of TGF‐β/BMP signaling
Miyazono, K., Kusanagi, K., & Inoue, H. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1080 · Cited by 503
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
Bruns, C. J., Solórzano, C. C., Harbison, M. T., Ozawa, S., Tsan, R. Z., Fan, D., Abbruzzese, J. L., Traxler, P. M., Buchdunger, E., Radinsky, R., et al. (2000) · PubMed · Cited by 498
TGF-β Signaling in Lung Health and Disease
Saito, A., Horie, M., & Nagase, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082460 · Cited by 515
Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β-catenin Mutations
Abraham, S. C., Klimstra, D. S., Wilentz, R. E., Yeo, C. J., Conlon, K. C., Brennan, M. F., Cameron, J. L., Wu, T., & Hruban, R. H. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62563-1 · Cited by 484
Self-citation
TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling
Abdollah, S., Macías‐Silva, M., Tsukazaki, T., Hayashi, H., Attisano, L., & Wrana, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27678 · Cited by 481
TGF-β and cancer
Bierie, B., & Moses, H. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.09.006 · Cited by 487
Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction
Datto, M., Frederick, J. P., Pan, L., Borton, A. J., Zhuang, Y., & Wang, X. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2495 · Cited by 470
SMADs: mediators and regulators of TGF-β signaling
Kretzschmar, M., & Massagué, J. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80069-5 · Cited by 467
A structural basis for mutational inactivation of the tumour suppressor Smad4
Shi, Y., Hata, A., Lo, R. S., Massagué, J., & Pavletich, N. P. (1997) · Nature · doi:10.1038/40431 · Cited by 461
Regulation of cell proliferation by Smad proteins
ten Dijke, P., Goumans, M., Itoh, F., & Itoh, S. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10066 · Cited by 453
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 465
Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexesPreprint
Liu, F., Pouponnot, C., & Massagué, J. (1997) · Genes & Development · doi:10.1101/gad.11.23.3157 · Cited by 445
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
Miyaki, M., Iijima, T., Konishi, M., Sakai, K., Ishii, A., Yasuno, M., Hishima, T., Koike, M., Shitara, N., Iwama∥, T., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202642 · Cited by 438
TGF-β receptor signaling
Derynck, R., & Feng, X. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00017-6 · Cited by 440
Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.
Murphy, K. M., Brune, K. A., Griffin, C. A., Sollenberger, J. E., Petersen, G. M., Bansal, R. K., Hruban, R. H., & Kern, S. E. (2002) · PubMed · Cited by 435
Self-citation

Authors: Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., & Kern, S. E.
Affiliations: Johns Hopkins University (US)
S. A. Hahn, M. Schutte, A. T. M. S. Hoque, C. A. Moskaluk, E. Rozenblum, C. L. Weinstein, A. Fischer, R. H. Hruban, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
L. T. da Costa, Graduate Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Corresponding author: Kern, Scott E.
ORCID: Hahn, Stephan A.
Moskaluk, Christopher A.
Fischer, Aryeh
Yeo, Charles J.
Hruban, Ralph H.
Kern, Scott E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-01-19
Volume: 271
Issue: 5247
Pages: 350-353
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.271.5247.350
OpenAlex: W2100522747
Cited by: 2,337
References: 25
Citations by year: 2026: 20 · 2025: 21 · 2024: 29 · 2023: 26 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 44 · 2018: 41 · 2017: 46 · 2016: 55 · 2015: 59 · 2014: 71 · 2013: 64 · 2012: 67
FWCI: 70.80
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P50CA062924, CA 62924)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: SMAD4, tumor suppressor, pancreatic cancer, homozygous deletion, loss of heterozygosity, TGF-beta signaling, loss-of-function mutations, candidate gene identification
MeSH terms: Alleles, Amino Acid Sequence, Animals, Base Sequence, Cell Division, Chromosome Mapping, Chromosomes, Human, Pair 18, DNA-Binding Proteins, Genetic Markers, Humans, Molecular Sequence Data, Mutation, Neoplasm Transplantation, Pancreatic Neoplasms, Proteins, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Trans-Activators, Gene Expression, Genes, Tumor Suppressor, Transforming Growth Factor beta, Gene Deletion, Mice, Smad4 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks