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Cited by 587Forensic and Genetic ResearchGenetic diversity and population structureGenetic Associations and Epidemiology

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Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins

Tishkoff, S. A., Dietzsch, E., Speed, W., Pakstis, A. J., Kidd, J. R., Cheung, K., Bonné-Tamir, B., Santachiara-Benerecetti, A. S., Moral, P., Krings, M., Pääbo, S., Watson, E., Risch, N., Jenkins, T., Kidd, K. K.·1996·Science
DOI 10.1126/science.271.5254.1380
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Abstract

Haplotypes consisting of alleles at a short tandem repeat polymorphism (STRP) and an Alu deletion polymorphism at the CD4 locus on chromosome 12 were analyzed in more than 1600 individuals sampled from 42 geographically dispersed populations (13 African, 2 Middle Eastern, 7 European, 9 Asian, 3 Pacific, and 8 Amerindian). Sub-Saharan African populations had more haplotypes and exhibited more variability in frequencies of haplotypes than the Northeast African or non-African populations. The Alu deletion was nearly always associated with a single STRP allele in non-African and Northeast African populations but was associated with a wide range of STRP alleles in the sub-Saharan African populations. This global pattern of haplotype variation and linkage disequilibrium suggests a common and recent African origin for all non-African human populations.

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  1. 10.1073/pnas.91.15.6787 · DOI
  2. 10.1073/pnas.91.25.12288 · DOI
  3. 10.1111/j.1399-0039.1981.tb01404.x · DOI
  4. 10.1084/jem.177.5.1343 · DOI
  5. BOWCOCK M. A., GENE GEOGR 5, 151 (1991).
  6. 10.1038/368455a0 · DOI
  7. 10.1073/pnas.88.3.839 · DOI
  8. CASTIGLIONE M. C., EVOLUTION OF HAPLOTYPES AT THE DRD2 LOCUS, AMERICAN JOURNAL OF HUMAN GENETICS 57, 1445 (1995).
  9. 10.1073/pnas.85.16.6002 · DOI
  10. DEKA R, POPULATION-GENETICS OF DINUCLEOTIDE (DC-DA)(N)CENTER-DOT(DG-DT)(N) POLYMORPHISMS IN WORLD POPULATIONS, AMERICAN JOURNAL OF HUMAN GENETICS 56, 461 (1995).
  11. 10.1073/pnas.88.5.1597 · DOI
  12. 10.1073/pnas.91.8.3166 · DOI
  13. 10.1126/science.7761836 · DOI
  14. 10.1128/MCB.15.6.3179 · DOI
  15. 10.1016/S0888-7543(05)80156-9 · DOI
  16. 10.1093/nar/19.17.4791-a · DOI
  17. 10.1128/mcb.13.5.2952-2958.1993 · DOI
  18. 10.1093/genetics/139.1.463 · DOI
  19. 10.1073/pnas.92.15.6723 · DOI
  20. 10.1038/378379a0 · DOI
  21. HAKIM I, PLURIDISCIPLINARY AP: 43 (1990).
  22. 10.1038/378376a0 · DOI
  23. 10.1086/204195 · DOI
  24. 10.1007/BF00178865 · DOI
  25. 10.1093/oxfordjournals.jhered.a111613 · DOI
  26. 10.1126/science.1738849 · DOI
  27. HILL A, INTEGRATIVE PATHS PA: 123 (1994).
  28. 10.1073/pnas.92.2.532 · DOI
  29. 10.1038/319449b0 · DOI
  30. JORDE B. L., ORIGINS AND AFFINITIES OF MODERN HUMANS - A COMPARISON OF MITOCHONDRIAL AND NUCLEAR GENETIC DATA, AMERICAN JOURNAL OF HUMAN GENETICS 57, 523 (1995).
  31. KIDD K. K., IN PRESS ALCOHOLISM .
  32. 10.1002/evan.1360030206 · DOI
  33. 10.1093/sysbio/41.1.111 · DOI
  34. 10.1093/hmg/2.4.431 · DOI
  35. MARTINSON J. J., HIGH DIVERSITY OF ALPHA-GLOBIN HAPLOTYPES IN A SENEGALESE POPULATION, INCLUDING MANY PREVIOUSLY UNREPORTED VARIANTS, AMERICAN JOURNAL OF HUMAN GENETICS 57, 1186 (1995).
  36. MCNEMAR Q, PSYCHOL STATISTICS (1969).
  37. 10.1007/BF02102807 · DOI
  38. 10.1159/000153872 · DOI
  39. NEI M, EVOLUTIONARY RELATIONSHIPS OF HUMAN-POPULATIONS ON A GLOBAL-SCALE, MOLECULAR BIOLOGY AND EVOLUTION 10, 927 (1993).
  40. 10.7312/nei-92038 · DOI
  41. PENNY D, IMPROVED ANALYSES OF HUMAN MTDNA SEQUENCES SUPPORT A RECENT AFRICAN ORIGIN FOR HOMO-SAPIENS, MOLECULAR BIOLOGY AND EVOLUTION 12, 863 (1995).
  42. 10.1093/genetics/105.3.767 · DOI
  43. 10.1038/ng0295-152 · DOI
  44. RITTE U, MITOCHONDRIAL-DNA AFFINITY OF SEVERAL JEWISH COMMUNITIES, HUMAN BIOLOGY 65, 359 (1993).
  45. ROGERS R. A., GENETIC-EVIDENCE ON MODERN HUMAN ORIGINS, HUMAN BIOLOGY 67, 1 (1995).
  46. 10.1073/pnas.88.4.1570 · DOI
  47. 10.1073/pnas.91.15.7184 · DOI
  48. 10.1002/ajpa.1330200218 · DOI
  49. 10.1093/genetics/134.3.983 · DOI
  50. 10.1093/genetics/137.1.331 · DOI · Paper page
  51. 10.1093/genetics/139.1.457 · DOI
  52. SLATKIN M, HITCHHIKING AND ASSOCIATIVE OVERDOMINANCE AT A MICROSATELLITE LOCUS, MOLECULAR BIOLOGY AND EVOLUTION 12, 473 (1995).
  53. STRINGER B. C., HOMO SAPIENS EVOLUTI: 9 (1992).
  54. STRINGER B. C., ORIGIN EVOLUTION HUM: 75 (1993).
  55. 10.1126/science.3125610 · DOI
  56. 10.1126/science.8108729 · DOI · Paper page
  57. TAMURA K, ESTIMATION OF THE NUMBER OF NUCLEOTIDE SUBSTITUTIONS IN THE CONTROL REGION OF MITOCHONDRIAL-DNA IN HUMANS AND CHIMPANZEES, MOLECULAR BIOLOGY AND EVOLUTION 10, 512 (1993).
  58. 10.1016/0959-437X(94)90067-1 · DOI
  59. 10.1525/aa.1993.95.1.02a00030 · DOI
  60. 10.1126/science.1590849 · DOI
  61. TISHKOFF A. S., AM J HUM GENET S 57, A42 (1995).
  62. TISHKOFF A. S., AM J PHYS ANTHR S 20, 211 (1995).
  63. 10.1093/genetics/133.3.737 · DOI
  64. 10.1126/science.1840702 · DOI
  65. 10.1038/319491a0 · DOI
  66. 10.1093/hmg/2.8.1123 · DOI
  67. 10.1073/pnas.63.4.1088 · DOI
  68. WOLPOFF M, HUMAN REVOLUTION BEH 1, 62 (1989).
  69. WOLPOFF H. M., HOMO SAPIENS EVOLUTI: 25 (1992).
  70. WORKMAN L. P., POPULATION STUDIES ON SOUTHWESTERN INDIAN TRIBES .2. LOCAL GENETIC DIFFERENTIATION IN PAPAGO, AMERICAN JOURNAL OF HUMAN GENETICS 22, 24 (1970).
  71. 10.1038/378489a0 · DOI
  72. ZOOSSMANNDISKIN A, GENETIC AFFINITIES OF ETHIOPIAN JEWS, ISRAEL JOURNAL OF MEDICAL SCIENCES 27, 245 (1991).

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Metadata

Authors
Tishkoff, S. A., Dietzsch, E., Speed, W., Pakstis, A. J., Kidd, J. R., Cheung, K., Bonné-Tamir, B., Santachiara-Benerecetti, A. S., Moral, P., Krings, M., Pääbo, S., Watson, E., Risch, N., Jenkins, T., & Kidd, K. K.
Affiliations
  • Yale University (US)
  • University of the Witwatersrand (ZA)
  • B. Bonné-Tamir is in the Department of Human Genetics, Sackler Faculty of Medicine, Tel Aviv University, 69978 Ramat Aviv, Israel.
  • A. S. Santachiara-Benerecetti is in the Buzzati Traverso Department of Genetics and Microbiology, University of Pavia, Via Abbiategrasso 207, 27100 Pavia, Italy.
  • Universitat de Barcelona (ES)
  • Ludwig-Maximilians-Universität München (DE)
  • Massey University (NZ)
  • Stanford Medicine (US)
  • S. A. Tishkoff, W. Speed, A. J. Pakstis, J. R. Kidd, K. Cheung, and K. K. Kidd are in the Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8005, USA.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-03-08
Volume
271
Issue
5254
Pages
1380-1387
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.271.5254.1380
OpenAlex
W1971604012
Cited by
587
References
64
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 9 · 2020: 5 · 2019: 1 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 12 · 2013: 10 · 2012: 14
FWCI
27.44
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • National Institutes of Health (5r01hg000348-09)
  • National Institute on Alcohol Abuse and Alcoholism (R01AA009379, AA09379)
  • National Institute of Mental Health (MH39 239)
  • National Human Genome Research Institute (HG00348)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
linkage disequilibrium, chromosome 12, short tandem repeat polymorphism, haplotype variation, human origins, African origin of modern humans, sub-Saharan African populations, population genetics
MeSH terms
Africa, Alleles, Animals, Base Sequence, Chromosomes, Human, Pair 12, Gene Frequency, Haplotypes, Humans, Molecular Sequence Data, Polymorphism, Genetic, Primates, Repetitive Sequences, Nucleic Acid, Genetic Variation, Hominidae, CD4 Antigens, Linkage Disequilibrium, Sequence Deletion, Evolution, Molecular

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