The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury
Abstract
A number of pathophysiologically relevant genes, including platelet-derived growth factor B-chain (PDGF-B), are induced in the vasculature after acute mechanical injury. In rat aorta, the activated expression of these genes was preceded by a marked increase in the amount of the early-growth-response gene product Egr-1 at the endothelial wound edge. Egr-1 interacts with a novel element in the proximal PDGF-B promoter, as well as with consensus elements in the promoters of other genes induced by endothelial injury. This interaction is crucial for injury-induced PDGF-B promoter-dependent expression. Sp1, whose binding site in the PDGF-B promoter overlaps that of Egr-1, occupies this element in unstimulated cells and is displaced by increasing amounts of Egr-1. These findings implicate Egr-1 in the up-regulated expression of PDGF-B and other potent mediators in mechanically injured arterial endothelial cells.
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Cites
Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis.
Gimbrone, M. A. (1995) · The American Journal of Cardiology · doi:10.1016/0002-9149(95)80016-l · Cited by 225
Cited by
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Shoshani, T., Faerman, A., Mett, I., Zelin, E., Tenne, T., Gorodin, S., Moshel, Y., Elbaz, S., Budanov, A., Chajut, A., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2283-2293.2002 · Cited by 546
Clayton, D. F. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.3967 · Cited by 322
Tremblay, J. J., & Drouin, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2567 · Cited by 272
Tissue Repair with a Therapeutic Transcription Factor
Bryant, M., Drew, G. M., Houston, P., Hissey, P., Campbell, C. J., & Braddock, M. (2000) · Human Gene Therapy · doi:10.1089/104303400750001444 · Cited by 74
Niu, F., Yao, H., Zhang, W., Sutliff, R. L., & Buch, S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1139-14.2014 · Cited by 58
Metadata
- Authors
- Khachigian, L. M., Lindner, V., Williams, A. J., & Collins, T.
- Venue
- Science
- Published
- 1996-03-08
- Volume
- 271
- Issue
- 5254
- Pages
- 1427-1431
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071366179
- Cited by
- 517
- References
- 1
- FWCI
- 22.51
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
