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The Elasticity of a Single Supercoiled DNA Molecule
Abstract
Single linear DNA molecules were bound at multiple sites at one extremity to a treated glass cover slip and at the other to a magnetic bead. The DNA was therefore torsionally constrained. A magnetic field was used to rotate the beads and thus to coil and pull the DNA. The stretching force was determined by analysis of the Brownian fluctuations of the bead. Here, the elastic behavior of individual λ DNA molecules over- and underwound by up to 500 turns was studied. A sharp transition was discovered from a low to a high extension state at a force of ∼0.45 piconewtons for underwound molecules and at a force of ∼3 piconewtons for overwound ones. These transitions, probably reflecting the formation of alternative structures in stretched coiled DNA molecules, might be relevant for DNA transcription and replication.
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Cited by
Jalili, N., & Laxminarayana, K. (2004) · Mechatronics · doi:10.1016/j.mechatronics.2004.04.005 · Cited by 610
Single chain spectroscopy of conformational dependence of conjugated polymer photophysics
Huser, T., Yan, M., & Rothberg, L. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11187 · Cited by 322
Single-Molecule Measurements of the Persistence Length of Double-Stranded RNA
Abels, J. A., Moreno-Herrero, F., van der Heijden, T., Dekker, C., & Dekker, N. H. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.052811 · Cited by 269
Revisiting the central dogma one molecule at a time
Bustamante, C., Cheng, W., & Mejia, Y. X. (2011) · Cell · doi:10.1016/j.cell.2011.01.033 · Cited by 173
Bianco, P., Bongini, L., Melli, L., Dolfi, M., & Lombardi, V. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.06.039 · Cited by 28
Metadata
- Authors
- Strick, T. R., Allemand, J.-F., Bensimon, D., Bensimon, A., & Croquette, V.
- Venue
- Science
- Published
- 1996-03-29
- Volume
- 271
- Issue
- 5257
- Pages
- 1835-1837
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2001907809
- Cited by
- 1,260
- References
- 0
- FWCI
- 21.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Strick, T. R., Allemand, J.-F., Bensimon, D., Bensimon, A., & Croquette, V. (1996). The Elasticity of a Single Supercoiled DNA Molecule. Science. https://doi.org/10.1126/science.271.5257.1835
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
