The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Age-Dependent Diarrhea Induced by a Rotaviral Nonstructural Glycoprotein
Abstract
The rotavirus nonstructural glycoprotein NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelope as subviral particles bud into the endoplasmic reticulum. NSP4 also causes an increase in intracellular calcium in insect cells. Purified NSP4 or a peptide corresponding to NSP4 residues 114 to 135 induced diarrhea in young (6 to 10 days old) CD1 mice. This disease response was age-dependent, dose-dependent, and specific. Electrophysiologic data from intestinal mucosa showed that the NSP4 114–135 peptide potentiates chloride secretion by a calcium-dependent signaling pathway. Diarrhea is induced when NSP4, acting as a viral enterotoxin, triggers a signal transduction pathway.
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Metadata
- Authors
- Ball, J. M., Tian, P., Zeng, C. Q.-Y., Morris, A. P., & Estes, M. K.
- Venue
- Science
- Published
- 1996-04-05
- Volume
- 272
- Issue
- 5258
- Pages
- 101-104
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990876250
- Cited by
- 688
- References
- 22
- FWCI
- 33.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ball, J. M., Tian, P., Zeng, C. Q.-Y., Morris, A. P., & Estes, M. K. (1996). Age-Dependent Diarrhea Induced by a Rotaviral Nonstructural Glycoprotein. Science. https://doi.org/10.1126/science.272.5258.101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
