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Identification of Yeast Rho1p GTPase as a Regulatory Subunit of 1,3-β-Glucan Synthase
Abstract
1,3-β-D-Glucan synthase [also known as β(1→3)glucan synthase] is a multi-enzyme complex that catalyzes the synthesis of 1,3-β-linked glucan, a major structural component of the yeast cell wall. Temperature-sensitive mutants in the essential Rho-type guanosine triphosphatase (GTPase), Rho1p, displayed thermolabile glucan synthase activity, which was restored by the addition of recombinant Rho1p. Glucan synthase from mutants expressing constitutively active Rho1p did not require exogenous guanosine triphosphate for activity. Rho1p copurified with β(1→3)glucan synthase and associated with the Fks1p subunit of this complex in vivo. Both proteins were localized predominantly at sites of cell wall remodeling. Therefore, it appears that Rho1p is a regulatory subunit of β(1→3)glucan synthase.
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Citations
Cited by
Rho GTPases and signaling networks
Van Aelst, L., & D’Souza-Schorey, C. (1997) · Genes & Development · doi:10.1101/gad.11.18.2295 · Cited by 2,358
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,767
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136
Self-citationThe cell wall: a carbohydrate armour for the fungal cell
Latgé, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05872.x · Cited by 987
The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species
Garcia-Rubio, R., de Oliveira, H. C., Rivera, J., & Trevijano-Contador, N. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02993 · Cited by 917
Metadata
- Authors
- Qadota, H., Python, C. P., Inoue, S. B., Arisawa, M., Anraku, Y., Zheng, Y., Watanabe, T., Levin, D. E., & Ohya, Y.
- Venue
- Science
- Published
- 1996-04-12
- Volume
- 272
- Issue
- 5259
- Pages
- 279-281
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034092404
- Cited by
- 445
- References
- 0
- FWCI
- 11.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Qadota, H., Python, C. P., Inoue, S. B., Arisawa, M., Anraku, Y., Zheng, Y., Watanabe, T., Levin, D. E., & Ohya, Y. (1996). Identification of Yeast Rho1p GTPase as a Regulatory Subunit of 1,3-β-Glucan Synthase. Science. https://doi.org/10.1126/science.272.5259.279
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