Molecular Pathways Controlling Heart Development
Abstract
Heart formation requires complex interactions among cells from multiple embryonic origins. Recent studies have begun to reveal the genetic pathways that control cardiac morphogenesis. Many of the genes within these pathways are conserved across vast phylogenetic distances, which has allowed cardiac development to be dissected in organisms ranging from flies to mammals. Studies of cardiac development have also revealed the molecular defects underlying several congenital cardiac malformations in humans and may ultimately provide opportunities for genetic testing and intervention.
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Vertebrates and insects share contractile heart cell types that do not use MyoD, but in which certain homeodomain transcriptional regulators of the NK2 family plus Mef2 factors are required for differentiation.
“Vertebrates and insects share contractile heart cell types that do not use MyoD, but in which certain homeodomain transcriptional regulators of the NK2 family plus the Mef2 factors are required for differentiation (Olson and Srivnastava, 1996) (reviewed by Bodmer and Venkatesh, 1998)”
From The last common bilaterian ancestor (2002) · cites this paper as Olson and Srivnastava, 1996
Cites
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
Shivdasani, R. A., Mayer, E. L., & Orkin, S. H. (1995) · Nature · doi:10.1038/373432a0 · Cited by 938 · see citing works
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GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
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Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
Benson, D. W., Silberbach, G. M., Kavanaugh-McHugh, A., Cottrill, C., Zhang, Y., Riggs, S., Smalls, O., Johnson, M. C., Watson, M. S., Seidman, J. G., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8154 · Cited by 690 · see citing works
The last common bilaterian ancestor
Erwin, D. H., & Davidson, E. H. (2002) · Development · doi:10.1242/dev.129.13.3021 · Cited by 320 · see citing works
Dor, Y., Camenisch, T. D., Itin, A., Fishman, G. I., McDonald, J. A., Carmeliet, P., & Keshet, E. (2001) · Development · doi:10.1242/dev.128.9.1531 · Cited by 240 · see citing works
- Authors
- Olson, E. N., & Srivastava, D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Olson, Eric N.
- Venue
- Science
- Published
- 1996-05-03
- Volume
- 272
- Issue
- 5262
- Pages
- 671-676
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037241011
- Cited by
- 478
- References
- 3
- Citations by year
- 2025: 2 · 2022: 10 · 2021: 14 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 10 · 2014: 5 · 2013: 12 · 2012: 7
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- heart development, cardiac morphogenesis, molecular pathways, congenital heart disease, gene pathways, evolutionary conservation, genetic testing, developmental genetics
- MeSH terms
- Animals, Cell Differentiation, Genes, Genes, Regulator, Heart, Heart Conduction System, Heart Defects, Congenital, Humans, Morphogenesis, Mutation, Myocardium, Neural Crest, Transcription Factors, Transcription, Genetic, Gene Expression Regulation, Developmental
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