A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · see citing works

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,114 · see citing works

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,624 · see citing works

VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

Gerber, H. P., Vu, T. H., Ryan, A. M., Kowalski, J., Werb, Z., & Ferrara, N. (1999) · Nature Medicine · doi:10.1038/9467 · Cited by 2,089 · see citing works

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

Levy, A. P., Levy, N. S., Wegner, S. A., & Goldberg, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13333 · Cited by 1,066 · see citing works

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

de la Pompa, J. L., Timmerman, L. A., Takimoto, H., Yoshida, H., Elia, A. J., Samper, E., Potter, J., Wakeham, A., Marengere, L., Langille, B. L., et al. (1998) · Nature · doi:10.1038/32419 · Cited by 660 · see citing works

Molecular Regulation of Atrioventricular Valvuloseptal Morphogenesis

Eisenberg, L. M., & Markwald, R. R. (1995) · Circulation Research · doi:10.1161/01.res.77.1.1 · Cited by 650 · see citing works

The transcription factor NF-ATc is essential for cardiac valve formation

Ranger, A. M., Grusby, M. J., Hodge, M. R., Gravallese, E. M., de la Brousse, F. C., Hoey, T., Mickanin, C., Baldwin, H. S., & Glimcher, L. H. (1998) · Nature · doi:10.1038/32426 · Cited by 586 · see citing works

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

Benjamin, L. E., & Keshet, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8761 · Cited by 507 · see citing works

Molecular Pathways Controlling Heart Development

Olson, E. N., & Srivastava, D. (1996) · Science · doi:10.1126/science.272.5262.671 · Cited by 478 · see citing works

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

Banai, S., Shweiki, D., Pinson, A., Chandra, M., Lazarovici, G., & Keshet, E. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.8.1176 · Cited by 429 · see citing works

Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression

Miquerol, L., Langille, B. L., & Nagy, A. (2000) · Development · doi:10.1242/dev.127.18.3941 · Cited by 429 · see citing works

Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases.

Pe'er, J., Shweiki, D., Itin, A., Hemo, I., Gnessin, H., & Keshet, E. (1995) · PubMed · Cited by 422 · see citing works

Developmental regulation of myosin gene expression in mouse cardiac muscle.

Lyons, G. E., Schiaffino, S., Sassoon, D. A., Barton, P. J. R., & BUCKINGHAM, M. E. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.2427 · Cited by 415 · see citing works

Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart

Brown, C. B., Boyer, A. S., Runyan, R. B., & Barnett, J. V. (1999) · Science · doi:10.1126/science.283.5410.2080 · Cited by 383 · see citing works

Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.

Drake, C. J., & Little, C. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7657 · Cited by 332 · see citing works

Invasion of mesenchyme into three-dimensional collagen gels: A regional and temporal analysis of interaction in embryonic heart tissue

Runyan, R. B., & Markwald, R. R. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90010-6 · Cited by 267 · see citing works

Overexpression of Vascular Endothelial Growth Factor in the Avian Embryo Induces Hypervascularization and Increased Vascular Permeability without Alterations of Embryonic Pattern Formation

Flamme, I., von Reutern, M., Drexler, H. C. A., Syed-Ali, S., & Risau, W. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1291 · Cited by 220 · see citing works

Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells.

Barleon, B., Siemeister, G., Martiny‐Baron, G., Weindel, K., Herzog, C., & Marmé, D. (1997) · PubMed · Cited by 214 · see citing works

Homologous Up-regulation of KDR/Flk-1 Receptor Expression by Vascular Endothelial Growth Factor in Vitro

Shen, B., Lee, D. Y., Gerber, H., Keyt, B. A., Ferrara, N., & Zioncheck, T. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29979 · Cited by 211 · see citing works

TGFβ2 and TGFβ3 Have Separate and Sequential Activities during Epithelial–Mesenchymal Cell Transformation in the Embryonic Heart

Boyer, A. S., Ayerinskas, I. I., Vincent, É., McKinney, L. A., Weeks, D. L., & Runyan, R. B. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9211 · Cited by 204 · see citing works

Vascular Endothelial Growth Factor Activates Nuclear Factor of Activated T Cells in Human Endothelial Cells: a Role for Tissue Factor Gene Expression

Armesilla, A. L., Lorenzo, E., Arco, P. G., Martı́nez-Martı́nez, S., Alfranca, A., & Redondo, J. M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2032 · Cited by 198 · see citing works

Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system.

Kremer, C., Breier, G., Risau, W., & Plate, K. H. (1997) · PubMed · Cited by 189 · see citing works

Neurofibromin modulation of ras activity is required for normal endocardial-mesenchymal transformation in the developing heart

Lakkis, M. M., & Epstein, J. A. (1998) · Development · doi:10.1242/dev.125.22.4359 · Cited by 183 · see citing works

Migratory behavior of cardiac cushion tissue cells in a collagen-lattice culture system

Bernanke, D. H., & Markwald, R. R. (1982) · Developmental Biology · doi:10.1016/0012-1606(82)90030-6 · Cited by 182 · see citing works

Experimental Production of Congenital Anomalies

INGALLS, T. H., Curley, F. J., & Prindle, R. A. (1952) · New England Journal of Medicine · doi:10.1056/nejm195211132472004 · Cited by 165 · see citing works

Conditional Transgene Expression in the Heart

Yü, Z., Redfern, C. S., & Fishman, G. I. (1996) · Circulation Research · doi:10.1161/01.res.79.4.691 · Cited by 147 · see citing works

Prevalence of congenital cardiac anomalies at high altitude

Miao, C.-Y., Zuberbuhler, J. S., & Zuberbuhler, J. R. (1988) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(88)90378-6 · Cited by 110 · see citing works

Ischemia-Driven Angiogenesis

Dor, Y., & Keshet, E. (1997) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(97)00091-1 · Cited by 92 · see citing works

Extracellular Matrix Protein Fibulin-2 Is Expressed in the Embryonic Endocardial Cushion Tissue and Is a Prominent Component of Valves in Adult Heart

Zhang, H., Chu, M.-L., Pan, T., Sasaki, T., Timpl, R., & Ekblom, P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1003 · Cited by 88 · see citing works

Regulated expression of foreign genes in vivo after germline transfer.

Passman, R. S., & Fishman, G. I. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117609 · Cited by 86 · see citing works

Mechanisms of Segmentation, Septation, and Remodeling of the Tubular Heart

Mjaatvedt, C. H., Yamamura, H., Wessels, A., Ramsdell, A. F., Turner, D., & Markwald, R. R. (1999) · Elsevier eBooks · doi:10.1016/b978-012329860-7/50012-x · Cited by 79 · see citing works

VEGF induces cardiovascular malformation and embryonic lethality.

Feucht, M., Christ, B., & Wilting, J. (1997) · Europe PMC (PubMed Central) · Cited by 56 · see citing works

Molecular basis of cardiovascular disease: a companion to Braunwald’s heart disease

Kent, K. C. (1999) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(99)70096-0 · Cited by 38 · see citing works

The effects of moderate hypoxia and moderate hypoxia plus hypercapnea on cardiac development in chick embryos

Jaffee, O. C. (1974) · Teratology · doi:10.1002/tera.1420100310 · Cited by 29 · see citing works

Transcription and the broken heart

Nolan, G. P. (1998) · Nature · doi:10.1038/32290 · Cited by 21 · see citing works

Abnormal Development of the Rat Heart During Prenatal Hypoxic Stress.

Clemmer, T. P., & Telford, I. R. (1966) · Experimental Biology and Medicine · doi:10.3181/00379727-121-30891 · Cited by 19 · see citing works

Abnormal Organogenesis in the Cardiovascular System

Jaffee, O. C. (1977) · Springer eBooks · doi:10.1007/978-1-4615-8933-4_14 · Cited by 15 · see citing works

Transcriptional regulation by calcium, calcineurin, and NFAT

Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991 · see citing works

The Role of Hypoxia in Development of the Mammalian Embryo

Dunwoodie, S. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.11.008 · Cited by 651 · see citing works

Heart Valve Development

Armstrong, E. J., & Bischoff, J. E. (2004) · Circulation Research · doi:10.1161/01.res.0000141146.95728.da · Cited by 648 · see citing works

Endothelial signaling during development

Cleaver, O. B., & Melton, D. A. (2003) · Nature Medicine · doi:10.1038/nm0603-661 · Cited by 518 · see citing works

Heart Valve Development

Combs, M. D., & Yutzey, K. E. (2009) · Circulation Research · doi:10.1161/circresaha.109.201566 · Cited by 456 · see citing works

Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

von Gise, A., & Pu, W. T. (2012) · Circulation Research · doi:10.1161/circresaha.111.259960 · Cited by 419 · see citing works

Conditional switching of VEGF provides new insights into adult neovascularization and pro‐angiogenic therapy

Dor, Y., Djonov, V., Abramovitch, R., Itin, A., Fishman, G. I., Carmeliet, P., Goelman, G., & Keshet, E. (2002) · The EMBO Journal · doi:10.1093/emboj/21.8.1939 · Cited by 389 · see citing works

Cell Biology of Cardiac Cushion Development

Person, A. D., Klewer, S. E., & Runyan, R. B. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)43005-3 · Cited by 369 · see citing works

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

Niessen, K., Fu, Y., Chang, L., Hoodless, P. A., McFadden, D., & Karsan, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710067 · Cited by 363 · see citing works

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases

Pardali, E., Sánchez‐Duffhues, G., Gomez‐Puerto, M. C., & ten Dijke, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102157 · Cited by 360 · see citing works

β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse

Liebner, S., Cattelino, A., Gallini, R., Rudini, N., Iurlaro, M., Piccolo, S., & Dejana, E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403050 · Cited by 376 · see citing works

A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

Chang, C.-P., Neilson, J. R., Bayle, J. H., Gestwicki, J. E., Kuo, A., Stankunas, K., Graef, I. A., & Crabtree, G. R. (2004) · Cell · doi:10.1016/j.cell.2004.08.010 · Cited by 331 · see citing works

Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development

Schulz, R. A., & Yutzey, K. E. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.10.008 · Cited by 291 · see citing works

Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2Preprint

Toyofuku, T., Zhang, H., Kumanogoh, A., Takegahara, N., Suto, F., Kamei, J., Aoki, K., Yabuki, M., Hori, M., Fujisawa, H., et al. (2004) · Genes & Development · doi:10.1101/gad.1167304 · Cited by 282 · see citing works

Temporal and Distinct TGFβ Ligand Requirements during Mouse and Avian Endocardial Cushion Morphogenesis

Camenisch, T. D., Molin, D. G. M., Person, A., Runyan, R. B., Gittenberger-de Groot, A. C., McDonald, J. A., & Klewer, S. E. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0731 · Cited by 279 · see citing works

Conditional Mineralocorticoid Receptor Expression in the Heart Leads to Life-Threatening Arrhythmias

Ouvrard‐Pascaud, A., Sainte–Marie, Y., Bénitah, J., Perrier, R., Soukaseum, C., Cat, A. N. D., Royer, A., Quang, K. L., Charpentier, F., Demolombe, S., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.503706 · Cited by 271 · see citing works

Notch Signaling in Cardiac Development

Niessen, K. S., & Karsan, A. (2008) · Circulation Research · doi:10.1161/circresaha.108.174318 · Cited by 257 · see citing works

Reengineering Inducible Cardiac-Specific Transgenesis With an Attenuated Myosin Heavy Chain Promoter

Sanbe, A., Gulick, J. M., Hanks, M. C., Liang, Q., Osińska, H. E., & Robbins, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000065442.64694.9f · Cited by 249 · see citing works

ENDOTHELIAL-CARDIOMYOCYTE INTERACTIONS IN CARDIAC DEVELOPMENT AND REPAIR

Hsieh, P. C. H., Davis, M. E., Lisowski, L. K., & Lee, R. T. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124629 · Cited by 242 · see citing works

Genomic frontiers in congenital heart disease

Morton, S. U., Quiat, D., Seidman, J. G., & Seidman, C. E. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00587-4 · Cited by 239 · see citing works

VEGF-A in Cardiomyocytes and Heart Diseases

Braile, M., Marcella, S., Cristinziano, L., Galdiero, M. R., Modestino, L., Ferrara, A. L., Varricchi, G., Marone, G., & Loffredo, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155294 · Cited by 240 · see citing works

Partitioning the heart: mechanisms of cardiac septation and valve development

Lin, C., Lin, C., Chen, C.-H., Zhou, B., & Chang, C. (2012) · Development · doi:10.1242/dev.063495 · Cited by 219 · see citing works

Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling

Schroeder, J. A., Jackson, L. F., Lee, D. C., & Camenisch, T. D. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0456-5 · Cited by 207 · see citing works

The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation

Yin, Z., Haynie, J. M., Yang, X., Han, B., Kiatchoosakun, S., Restivo, J., Yuan, S., Prabhakar, N. R., Herrup, K., Conlon, R. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162371799 · Cited by 197 · see citing works

Loss of Gata5 in mice leads to bicuspid aortic valve

Laforest, B., Andelfinger, G., & Nemer, M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44555 · Cited by 190 · see citing works

How to Make a Heart Valve: From Embryonic Development to Bioengineering of Living Valve SubstitutesPreprint

MacGrogan, D., Luxán, G., Driessen‐Mol, A., Bouten, C. V. C., Baaijens, F. F., & de la Pompa, J. L. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013912 · Cited by 189 · see citing works

Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field

Rivera‐Feliciano, J., & Tabin, C. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.03.043 · Cited by 178 · see citing works

Endothelial cell–cardiomyocyte crosstalk in heart development and disease

Colliva, A., Braga, L., Giacca, M., & Zacchigna, S. (2019) · The Journal of Physiology · doi:10.1113/jp276758 · Cited by 170 · see citing works

Valvulogenesis: the moving target

Butcher, J. T., & Markwald, R. R. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2130 · Cited by 156 · see citing works

Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins

Renz, M., Otten, C., Faurobert, E., Rudolph, F., Zhu, Y., Boulday, G., Duchêne, J., Mickoleit, M., Dietrich, A.-C., Ramspacher, C., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2014.12.016 · Cited by 153 · see citing works

Origin and fate of cardiac mesenchyme

Snarr, B. S., Kern, C. B., & Wessels, A. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21725 · Cited by 153 · see citing works

Human Pulmonary Valve Progenitor Cells Exhibit Endothelial/Mesenchymal Plasticity in Response to Vascular Endothelial Growth Factor-A and Transforming Growth Factor-β 2

Paruchuri, S. M., Yang, J.-H., Aikawa, E. R., Melero‐Martin, J. M., Khan, Z. A., Loukogeorgakis, S., Schöen, F. J., & Bischoff, J. E. (2006) · Circulation Research · doi:10.1161/01.res.0000245188.41002.2c · Cited by 153 · see citing works

Prevalence of Congenital Heart Defects in Monochorionic/Diamniotic Twin Gestations

Bahtiyar, M. O., Dulay, A. T., Weeks, B. P., Friedman, A. H., & Copel, J. A. (2007) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2007.26.11.1491 · Cited by 148 · see citing works

Hypoxia Induces Dilated Cardiomyopathy in the Chick Embryo: Mechanism, Intervention, and Long-Term Consequences

Tintu, A. N., Rouwet, E. V., Verlohren, S., Brinkmann, J. F. F., Ahmad, S., Crispi, F., van Bilsen, M., Carmeliet, P., Staff, A. C., Tjwa, M., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005155 · Cited by 147 · see citing works

The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development

Ward, N. L., & Dumont, D. (2002) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2001.0288 · Cited by 147 · see citing works

Endothelium-Microenvironment Interactions in the Developing Embryo and in the Adult

Red‐Horse, K., Crawford, Y., Shojaei, F., & Ferrara, N. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.01.013 · Cited by 134 · see citing works

An Excess of Deleterious Variants in VEGF-A Pathway Genes in Down-Syndrome-Associated Atrioventricular Septal Defects

Ackerman, C. M., Locke, A. E., Feingold, E., Reshey, B., España, K., Thusberg, J., Mooney, S. D., Bean, L. J., Dooley, K. J., Cua, C. L., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.08.017 · Cited by 122 · see citing works

VEGF-C and aortic cardiomyocytes guide coronary artery stem development

Chen, H. I., Poduri, A., Nurmi, H. J., Kivelä, R., Saharinen, P., McKay, A. S., Raftrey, B. C., Churko, J. M., Tian, X., Zhou, B., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci77483 · Cited by 122 · see citing works

Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation

Jones, H. N., Olbrych, S. K., Smith, K. L., Cnota, J. F., Habli, M. A., Ramos-Gonzales, O., Owens, K. J., Hinton, A. C., POLZIN, W. J., Muglia, L. J., et al. (2015) · Placenta · doi:10.1016/j.placenta.2015.08.003 · Cited by 121 · see citing works

Role of VEGF in organogenesis

Haigh, J. J. (2008) · Organogenesis · doi:10.4161/org.4.4.7415 · Cited by 119 · see citing works

Mechanisms of heart valve development and disease

O’Donnell, A., & Yutzey, K. E. (2020) · Development · doi:10.1242/dev.183020 · Cited by 124 · see citing works

The Matricellular Protein CCN1 Is Essential for Cardiac Development

Mo, F.-E., & Lau, L. F. (2006) · Circulation Research · doi:10.1161/01.res.0000248426.35019.89 · Cited by 112 · see citing works

NFATc1 Mediates Vascular Endothelial Growth Factor-induced Proliferation of Human Pulmonary Valve Endothelial Cells

Johnson, E. N., Lee, Y. M., Sander, T. L., Aikawa, E. R., Schöen, F. J., Kaushal, S., & Bischoff, J. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210250200 · Cited by 112 · see citing works

N-Acetylcysteine prevents congenital heart defects induced by pregestational diabetes

Moazzen, H., Lu, X., Ma, N. L., Velenosi, T. J., Urquhart, B. L., Wisse, L. J., Gittenberger-de Groot, A. C., & Feng, Q. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-46 · Cited by 111 · see citing works

Regulation of Proangiogenic Factor CCN1 in Cardiac Muscle: Impact of Ischemia, Pressure Overload, and Neurohumoral Activation

Hilfiker-Kleiner, D., Kaminski, K., Kaminska, A., Fuchs, M., Klein, G., Podewski, E., Grote, K., Kiian, I., Wollert, K. C., Hilfiker, A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127952.90508.9d · Cited by 110 · see citing works

Human Embryonic Stem Cell–Derived Mesoderm-like Epithelium Transitions to Mesenchymal Progenitor Cells

Boyd, N. L., Robbins, K. R., Dhara, S. K., West, F. D., & Stice, S. L. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0351 · Cited by 108 · see citing works

A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels

Hallaq, H., Pinter, E., Enciso, J., McGrath, J. M., Zeiss, C. J., Brueckner, M. K., Madri, J. A., Jacobs, H. C., Wilson, C., Vasavada, H., et al. (2004) · Development · doi:10.1242/dev.01393 · Cited by 107 · see citing works

Blood Vessel Organoids for Development and Disease

Salewskij, K., & Penninger, J. M. (2023) · Circulation Research · doi:10.1161/circresaha.122.321768 · Cited by 100 · see citing works

Msx1 and Msx2are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

Chen, Y.-H., Ishii, M., Sucov, H. M., & Maxson, R. E. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-75 · Cited by 99 · see citing works

Blood vessels restrain pancreas branching, differentiation and growth

Magenheim, J., Ilovich, O., Lazarus, A., Klochendler, A., Ziv, O., Werman, R., Hija, A., Cleaver, O., Mishani, E., Keshet, E., et al. (2011) · Development · doi:10.1242/dev.066548 · Cited by 112 · see citing works

The Role of Abnormal Placentation in Congenital Heart Disease; Cause, Correlate, or Consequence?

Courtney, J. A., Cnota, J. F., & Jones, H. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01045 · Cited by 95 · see citing works

Elevated glucose inhibits VEGF-A–mediated endocardial cushion formation

Enciso, J., Gratzinger, D. A., Camenisch, T. D., Canosa, S., Pinter, E., & Madri, J. A. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209014 · Cited by 95 · see citing works

Heart Valve Development, Maintenance, and Disease

Tao, G., Kotick, J. D., & Lincoln, J. (2012) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00006-3 · Cited by 89 · see citing works

Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases

Jackson, A. O., Zhang, J., Jiang, Z., & Yin, K. (2017) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2017.03.003 · Cited by 89 · see citing works

VEGF is required for dendritogenesis of newly born olfactory bulb interneurons

Licht, T., Eavri, R., Goshen, I., Shlomai, Y., Mizrahi, A., & Keshet, E. (2010) · Development · doi:10.1242/dev.039636 · Cited by 86 · see citing works

Rbm24, a target of p53, is necessary for proper expression of p53 and heart development

Zhang, M., Zhang, Y., Xu, E., Mohibi, S., de Anda, D. M., Jiang, Y., Zhang, J., & Chen, X. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0029-8 · Cited by 86 · see citing works

Overexpression of Placenta Growth Factor Contributes to the Pathogenesis of Pulmonary Emphysema

Tsao, P., Su, Y., Li, H., Huang, P., Chien, C., Lai, Y., Lee, C., Chen, C., Cheng, W., Wei, S., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200306-774oc · Cited by 86 · see citing works

The zebrafish model system in cardiovascular research: A tiny fish with mighty prospects

Poon, K. L., & Brand, T. (2013) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2013.4 · Cited by 85 · see citing works

Risk of Vascular Anomalies With Down Syndrome

Greene, A. K., Kim, S., Rogers, G. F., Fishman, S. J., Olsen, B. R., & Mulliken, J. B. (2007) · PEDIATRICS · doi:10.1542/peds.2007-1316 · Cited by 83 · see citing works

Early events in valvulogenesis: A signaling perspective

Barnett, J. V., & Desgrosellier, J. S. (2003) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.10006 · Cited by 83 · see citing works

Developmental Mechanisms of Aortic Valve Malformation and Disease

Wu, B., Wang, Y., Xiao, F., Butcher, J. T., Yutzey, K. E., & Zhou, B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034001 · Cited by 81 · see citing works

VEGF signaling has distinct spatiotemporal roles during heart valve development

Stankunas, K., Ma, G. K., Kuhnert, F., Kuo, C. J., & Chang, C. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.030 · Cited by 78 · see citing works

Molecular Embryogenesis of the Heart

Kirby, M. L., & Waldo, K. L. (2002) · Pediatric and Developmental Pathology · doi:10.1007/s10024-002-0004-2 · Cited by 77 · see citing works

Coronary anatomy in congenitally corrected transposition of the great arteries

Ismat, F. A., Baldwin, H. S., Karl, T. R., & Weinberg, P. M. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00325-x · Cited by 76 · see citing works

VEGF and RANKL Regulation of NFATc1 in Heart Valve Development

Combs, M. D., & Yutzey, K. E. (2009) · Circulation Research · doi:10.1161/circresaha.109.196469 · Cited by 76 · see citing works

Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents

Mcquade, P. S., Martin, K. E., Castle, T. C., Went, M. J., Blower, P. J., Welch, M. J., & Lewis, J. S. (2005) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2004.10.004 · Cited by 75 · see citing works

DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice

Lange, A. W., Molkentin, J. D., & Yutzey, K. E. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.10.036 · Cited by 75 · see citing works

Elastin Haploinsufficiency Results in Progressive Aortic Valve Malformation and Latent Valve Disease in a Mouse Model

Hinton, R. B., Adelman-Brown, J., Witt, S. A., Krishnamurthy, V. K., Osińska, H. E., Sakthivel, B., James, J. F., Li, D. Y., Narmoneva, D. A., Mecham, R. P., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.221358 · Cited by 72 · see citing works

Signal transduction in early heart development (II): ventricular chamber specification, trabeculation, and heart valve formation.

Wagner, M. A., & Siddiqui, M. A. Q. (2007) · PubMed · Cited by 72 · see citing works

Signal transduction in early heart development (I): cardiogenic induction and heart tube formation.

Wagner, M. A., & Siddiqui, M. A. Q. (2007) · PubMed · Cited by 71 · see citing works

Expression of the BMP Receptor Alk3 in the Second Heart Field Is Essential for Development of the Dorsal Mesenchymal Protrusion and Atrioventricular Septation

Briggs, L. E., Phelps, A. L., Brown, E. E., Kakarla, J., Anderson, R. H., van den Hoff, M. J. B., & Wessels, A. (2013) · Circulation Research · doi:10.1161/circresaha.112.300821 · Cited by 71 · see citing works

Possible Common Aetiology behind Maternal Preeclampsia and Congenital Heart Defects in the Child: a Cardiovascular Diseases in N orway Project Study

Brodwall, K., Leirgul, E., Greve, G., Vollset, S. E., Holmstrøm, H., Tell, G. S., & Øyen, N. (2015) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12252 · Cited by 70 · see citing works

Recent Advances in Placenta–Heart Interactions

Maslen, C. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00735 · Cited by 69 · see citing works

Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis

Ahmad, S., Hewett, P. W., Al‐Ani, B., Sissaoui, S., Fujisawa, T., Cudmore, M., & Ahmed, A. (2011) · Vascular Cell · doi:10.1186/2045-824x-3-15 · Cited by 67 · see citing works

VEGF modulates early heart valve formation

Dor, Y., Klewer, S. E., McDonald, J. A., Keshet, E., & Camenisch, T. D. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10026 · Cited by 66 · see citing works

Angiogenesis — a self-adapting principle in hypoxia

Marti, H. H. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7311-3_12 · Cited by 66 · see citing works

Placental Pathology and Neuroimaging Correlates in Neonates with Congenital Heart Disease

Schlatterer, S. D., Murnick, J. G., Jacobs, M. B., White, L., Donofrio, M. T., & Limperopoulos, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-40894-y · Cited by 64 · see citing works

CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

Park, M.-H., Kim, A. K., Manandhar, S., Oh, S.-Y., Jang, G.-H., Kang, L., Lee, D., Hyeon, D. Y., Lee, S.-H., Lee, H., et al. (2019) · eLife · doi:10.7554/elife.46012 · Cited by 62 · see citing works

Hypoxia-responsive signaling regulates the apoptosis-dependent remodeling of the embryonic avian cardiac outflow tract

Sugishita, Y., Leifer, D. W., Agani, F. H., Watanabe, M., & Fisher, S. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.05.036 · Cited by 64 · see citing works

Effect of Polyelectrolyte Film Stiffness on Endothelial Cells During Endothelial-to-Mesenchymal Transition

Zhang, H., Chang, H., Wang, L., Ren, K., Martins, M. C. L., Barbosa, M. A., & Ji, J. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01057 · Cited by 63 · see citing works

Tetralogy of Fallot and Alterations in Vascular Endothelial Growth Factor-A Signaling and Notch Signaling in Mouse Embryos Solely Expressing the VEGF120 Isoform

van den Akker, N. M. S., Molin, D. G. M., Peters, P. P. W. M., Maas, S., Wisse, L. J., van Brempt, R., van Munsteren, C. J., Bartelings, M. M., Poelmann, R. E., Carmeliet, P., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000261656.04773.39 · Cited by 63 · see citing works

Depolymerized Hyaluronan Induces Vascular Endothelial Growth Factor, a Negative Regulator of Developmental Epithelial-to-Mesenchymal Transformation

Rodgers, L., Lalani, S., Hardy, K. M., Xiang, X., Broka, D. M., Antin, P. B., & Camenisch, T. D. (2006) · Circulation Research · doi:10.1161/01.res.0000242561.95978.43 · Cited by 63 · see citing works

Role of Hypoxia in the Evolution and Development of the Cardiovascular System

Fisher, S. A., & Burggren, W. W. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1704 · Cited by 62 · see citing works

Etiology of Valvular Heart Disease

Lincoln, J., & Garg, V. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0510 · Cited by 62 · see citing works

CCN1 protects cardiac myocytes from oxidative stress via β1 integrin–Akt pathway

Yoshida, Y., Togi, K., Matsumae, H., Nakashima, Y., Kojima, Y., Yamamoto, H., Ono, K., Nakamura, T., Kita, T., & Tanaka, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.195 · Cited by 59 · see citing works

Increased susceptibility of HIF-1α heterozygous-null mice to cardiovascular malformations associated with maternal diabetes

Bohuslavová, R., Skvorova, L., Sedmera, D., Semenza, G. L., & Pavlínková, G. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.04.015 · Cited by 55 · see citing works

A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion

Jiang, Y., Berry, D. C., Jo, A.-Y., Tang, W., Arpke, R. W., Kyba, M., & Graff, J. M. (2017) · Nature Communications · doi:10.1038/ncomms15926 · Cited by 53 · see citing works

Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish

Lee, Y. M., Cope, J. J., Ackermann, G. E., Goishi, K., Armstrong, E. J., Paw, B. H., & Bischoff, J. E. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20559 · Cited by 52 · see citing works

Genes in congenital heart disease: atrioventricular valve formation

Joziasse, I. C., van der Smagt, J. J., Smith, K., Bakkers, J., Sieswerda, G. T., Mulder, B. J. M., & Doevendans, P. A. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0713-4 · Cited by 52 · see citing works

Recent advances in inducible expression in transgenic mice

Albanese, C., Hulit, J., Sakamaki, T., & Pestell, R. G. (2002) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00021-6 · Cited by 52 · see citing works

Maternal serum placental growth factor at 11–13 weeks' gestation and fetal cardiac defects

Llurba, E., Syngelaki, A., Sánchez, O., Carreras, E., Cabero, L., & Nicolaides, K. H. (2012) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.12346 · Cited by 49 · see citing works

Endothelium as master regulator of organ development and growth

Tı̂rziu, D., & Simons, M. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.08.003 · Cited by 49 · see citing works

Opposing actions of Notch1 and VEGF in post-natal cardiac valve endothelial cells

Yang, J.-H., Wylie‐Sears, J., & Bischoff, J. E. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.07.057 · Cited by 49 · see citing works

Heart development: learning from mistakes

McFadden, D. G., & Olson, E. N. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00306-4 · Cited by 49 · see citing works

The Endocardium and Heart ValvesPreprint

Dye, B. K., & Lincoln, J. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036723 · Cited by 48 · see citing works

Clinical and molecular cytogenetic studies in ring chromosome 5: Report of a child with congenital abnormalities

Basinko, A., Uzielli, M. L. G., Scarselli, G., Priolo, M., Timpani, G., & Braekeleer, M. D. (2011) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2011.11.005 · Cited by 47 · see citing works

Wnt/β‐catenin and sonic hedgehog pathways interact in the regulation of the development of the dorsal mesenchymal protrusion

Briggs, L. E., Burns, T. A., Lockhart, M. M., Phelps, A. L., van den Hoff, M. J. B., & Wessels, A. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24339 · Cited by 47 · see citing works

Genome and epigenome analysis of monozygotic twins discordant for congenital heart disease

Lyu, G., Zhang, C., Ling, T., Liu, R., Zong, L., Guan, Y., Huang, X., Sun, L., Zhang, L., Li, C., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4814-7 · Cited by 47 · see citing works

Induction of Vascular Networks in Adult Organs: Implications to Proangiogenic Therapy

Dor, Y., Djonov, V., & Keshet, E. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03224.x · Cited by 47 · see citing works

Trichloroethylene Decreases Heat Shock Protein 90 Interactions with Endothelial Nitric Oxide Synthase: Implications for Endothelial Cell Proliferation

Ou, J. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg062 · Cited by 45 · see citing works

VEGF modulates early heart valve formation

Dor, Y., Klewer, S. E., McDonald, J. A., Keshet, E., & Camenisch, T. D. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10026 · Cited by 66 · see citing works

Excess VEGF‐A disrupts tubular heart formation and cardiac blood flow dynamics

Rugonyi, S., Rykiel, G., & Rongish, B. J. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.18.1

Hypoxic Induction of Myocardial Vascularization During Development

Tomanek, R. J., Lund, D. D., & Yue, X. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8997-0_10 · Cited by 32 · see citing works

Transient increase in VEGF‐A leads to cardiac tube anomalies and increased risk of congenital heart malformations

Rykiel, G., Gray, M. J., Rongish, B. J., & Rugonyi, S. (2021) · The Anatomical Record · doi:10.1002/ar.24605 · Cited by 6 · see citing works

Elevated vascular endothelial cell growth factor affects mesocardial morphogenesis and inhibits normal heart bending

Drake, C. J., Wessels, A., Trusk, T., & Little, C. D. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20539 · Cited by 21 · see citing works