The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia
Abstract
Zinc is present in presynaptic nerve terminals throughout the mammalian central nervous system and likely serves as an endogenous signaling substance. However, excessive exposure to extracellular zinc can damage central neurons. After transient forebrain ischemia in rats, chelatable zinc accumulated specifically in degenerating neurons in the hippocampal hilus and CA1, as well as in the cerebral cortex, thalamus, striatum, and amygdala. This accumulation preceded neurodegeneration, which could be prevented by the intraventricular injection of a zinc chelating agent. The toxic influx of zinc may be a key mechanism underlying selective neuronal death after transient global ischemic insults.
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Buchan, A. M., Li, H., Cho, S., & Pulsinelli, W. A. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90314-j · Cited by 255
Protection against ischemic hippocampal CAI damage in the rat with a new non-NMDA antagonist, NBQX
Diemer, N. H., Jørgensen, M. B., Johansen, F. F., Sheardown, M., & Honoré, T. (1992) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1992.tb08052.x · Cited by 106
Cited by
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Kambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158
Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors
Finney, L. A., & O'Halloran, T. V. (2003) · Science · doi:10.1126/science.1085049 · Cited by 1,100
Metadata
- Authors
- Koh, J.-Y., Suh, S. W., Gwag, B. J., He, Y. Y., Hsu, C. Y., & Choi, D. W.
- Venue
- Science
- Published
- 1996-05-17
- Volume
- 272
- Issue
- 5264
- Pages
- 1013-1016
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054566340
- Cited by
- 1,071
- References
- 2
- FWCI
- 40.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koh, J.-Y., Suh, S. W., Gwag, B. J., He, Y. Y., Hsu, C. Y., & Choi, D. W. (1996). The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia. Science. https://doi.org/10.1126/science.272.5264.1013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
