The DOI matches its Crossref record.
Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein
Abstract
The adenomatous polyposis coli gene ( APC ) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its product binds to the adherens junction protein β-catenin. Overexpression of APC blocks cell cycle progression. The APC-β-catenin complex was shown to bind to DLG, the human homolog of the Drosophila discs large tumor suppressor protein. This interaction required the carboxyl-terminal region of APC and the DLG homology repeat region of DLG. APC colocalized with DLG at the lateral cytoplasm in rat colon epithelial cells and at the synapse in cultured hippocampal neurons. These results suggest that the APC-DLG complex may participate in regulation of both cell cycle progression and neuronal function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Fanning, A. S., Jameson, B. J., Jesaitis, L. A., & Anderson, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29745 · Cited by 1,432
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
Matsuoka, M., & Jeang, K.-T. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2111 · Cited by 829
The colorectal adenoma–carcinoma sequence
Leslie, A., Carey, F. A., Pratt, N. R., & Steele, R. J. C. (2002) · British Journal of Surgery · doi:10.1046/j.1365-2168.2002.02120.x · Cited by 734
Metadata
- Authors
- Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G.-H., Kawahara, T., Kobayashi, S., Okada, M., Toyoshima, K., & Akiyama, T.
- Venue
- Science
- Published
- 1996-05-17
- Volume
- 272
- Issue
- 5264
- Pages
- 1020-1023
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085252478
- Cited by
- 424
- References
- 0
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein. https://app.cochat.ai/papers/10.1126/science.272.5264.1020
- The paper
- Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G.-H., Kawahara, T., Kobayashi, S., Okada, M., Toyoshima, K., & Akiyama, T. (1996). Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein. Science. https://doi.org/10.1126/science.272.5264.1020
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
