The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist
Abstract
The myogenic basic helix-loop-helix (bHLH) and MEF2 transcription factors are expressed in the myotome of developing somites and cooperatively activate skeletal muscle gene expression. The bHLH protein Twist is expressed throughout the epithelial somite and is subsequently excluded from the myotome. Ectopically expressed mouse Twist (Mtwist) was shown to inhibit myogenesis by blocking DNA binding by MyoD, by titrating E proteins, and by inhibiting trans-activation by MEF2. For inhibition of MEF2, Mtwist required heterodimerization with E proteins and an intact basic domain and carboxyl-terminus. Thus, Mtwist inhibits both families of myogenic regulators and may regulate myotome formation temporally or spatially.
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Citations
Cites
The MyoD family and myogenesis: Redundancy, networks, and thresholds
Weintraub, H. (1993) · Cell · doi:10.1016/0092-8674(93)90610-3 · Cited by 1,057
Jen, Y., Weintraub, H., & Benezra, R. (1992) · Genes & Development · doi:10.1101/gad.6.8.1466 · Cited by 471
Cited by
Understanding Adipocyte Differentiation
GREGOIRE, F. M., SMAS, C. M., & SUL, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,376
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
twist is a potential oncogene that inhibits apoptosis
Maestro, R., Tos, A. P. D., Hamamori, Y., Krasnokutsky, S., Sartorelli, V., Kedes, L., Doglioni, C., Beach, D. H., & Hannon, G. J. (1999) · Genes & Development · doi:10.1101/gad.13.17.2207 · Cited by 516
Hamamori, Y., Sartorelli, V., Ogryzko, V., Puri, P. L., Wu, H.-Y., Wang, J. Y. J., Nakatani, Y., & Kedes, L. (1999) · Cell · doi:10.1016/s0092-8674(00)80553-x · Cited by 368
The Id proteins and angiogenesis
Benezra, R., Rafii, S., & Lyden, D. (2001) · Oncogene · doi:10.1038/sj.onc.1205160 · Cited by 222
Metadata
- Authors
- Spicer, D. B., Rhee, J., Cheung, W. L., & Lassar, A. B.
- Venue
- Science
- Published
- 1996-06-07
- Volume
- 272
- Issue
- 5267
- Pages
- 1476-1480
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983019887
- Cited by
- 329
- References
- 2
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spicer, D. B., Rhee, J., Cheung, W. L., & Lassar, A. B. (1996). Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist. Science. https://doi.org/10.1126/science.272.5267.1476
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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