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Synergistic Activation of Estrogen Receptor with Combinations of Environmental Chemicals
Abstract
Certain chemicals in the environment are estrogenic. The low potencies of these compounds, when studied singly, suggest that they may have little effect on biological systems. The estrogenic potencies of combinations of such chemicals were screened in a simple yeast estrogen system (YES) containing human estrogen receptor (hER). Combinations of two weak environmental estrogens, such as dieldrin, endosulfan, or toxaphene, were 1000 times as potent in hER-mediated transactivation as any chemical alone. Hydroxylated polychlorinated biphenyls shown previously to synergistically alter sexual development in turtles also synergized in the YES. The synergistic interaction of chemical mixtures with the estrogen receptor may have profound environmental implications. These results may represent a previously uncharacterized level of regulation of estrogen-associated responses.
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Cited by
Pharmaceuticals and personal care products in the environment: agents of subtle change?
Daughton, C. G., & Ternes, T. A. (1999) · Environmental Health Perspectives · doi:10.1289/ehp.99107s6907 · Cited by 4,705
Kuiper, G. G. J. M., Carlsson, B., Grandien, K., Enmark, E., Häggblad, J., Nilsson, S., & Gustafsson, J.-A. (1997) · Endocrinology · doi:10.1210/endo.138.3.4979 · Cited by 4,442
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
Silva, E., Rajapakse, N., & Kortenkamp, A. (2002) · Environmental Science & Technology · doi:10.1021/es0101227 · Cited by 912
Shelby, M. D., Newbold, R. R., Tully, D. B., Chae, K., & Davis, V. L. (1996) · Environmental Health Perspectives · doi:10.1289/ehp.961041296 · Cited by 444
Metadata
- Authors
- Arnold, S. F., Klotz, D. M., Collins, B. M., Vonier, P. M., Guillette, L. J., & McLachlan, J. A.
- Venue
- Science
- Published
- 1996-06-07
- Volume
- 272
- Issue
- 5267
- Pages
- 1489-1492
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002021255
- Cited by
- 499
- References
- 0
- FWCI
- 80.24
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- Arnold, S. F., Klotz, D. M., Collins, B. M., Vonier, P. M., Guillette, L. J., & McLachlan, J. A. (1996). Synergistic Activation of Estrogen Receptor with Combinations of Environmental Chemicals. Science. https://doi.org/10.1126/science.272.5267.1489
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
