Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works

Cloning of a novel receptor expressed in rat prostate and ovary.

Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,792 · see citing works

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

Lubahn, D. B., Moyer, J. S., GOLDING, T. S., Couse, J. F., Korach, K. S., & Smithies, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11162 · Cited by 1,901 · see citing works

Persistent DDT metabolite p,p'–DDE is a potent androgen receptor antagonist

KELCE, W. R., Stone, C. R., Laws, S. C., Gray, L. E., Kemppainen, J., & Wilson, E. M. (1995) · Nature · doi:10.1038/375581a0 · Cited by 1,538 · see citing works

Plasma concentrations of phyto-oestrogens in Japanese men.

Adlercreutz, H., Markkanen, H., & Watanabe, S. (1993) · The Lancet · doi:10.1016/0140-6736(93)92188-y · Cited by 754 · see citing works

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

Katzenellenbogen, J., O'Malley, B., & Katzenellenbogen, B. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.2.8825552 · Cited by 537 · see citing works

Molecular cloning and charcterization of rat estrogen receptor cDNA

Koike, S., Sakai, M., & Muramatsu, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.6.2499 · Cited by 489 · see citing works

Transcription factors 3: nuclear receptors.

Gronemeyer, H., & Laudet, V. (1995) · PubMed · Cited by 321 · see citing works

Mechanisms of Action of Steroid Hormones

O’Malley, B. W. (1971) · New England Journal of Medicine · doi:10.1056/nejm197102182840710 · Cited by 293 · see citing works

Stereospecific binding of estrogens in the rat uterus

Noteboom, W. D., & Gorski, J. (1965) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(65)90235-3 · Cited by 272 · see citing works

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain

Beekman, J. M., Allan, G. F., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.10.8264659 · Cited by 260 · see citing works

Immunocytochemical Localization of Estradiol and Progesterone Receptors in the Monkey Ovary Throughout the Menstrual Cycle*

Hild-Petito, S. A., Stouffer, R. L., & Brenner, R. (1988) · Endocrinology · doi:10.1210/endo-123-6-2896 · Cited by 226 · see citing works

Zearalenones: Characterization of the Estrogenic Potencies and Receptor Interactions of a Series of Fungal β-Resorcylic Acid Lactones*

Katzenellenbogen, B. S., Katzenellenbogen, B. S., & MORDECAI, D. (1979) · Endocrinology · doi:10.1210/endo-105-1-33 · Cited by 197 · see citing works

The developmental pattern of androgen receptor expression in rat prostate lobes is altered after neonatal exposure to estrogen.

Prins, G. S., & Birch, L. A. (1995) · Endocrinology · doi:10.1210/endo.136.3.7867585 · Cited by 188 · see citing works

Dietary Estrogens Act through Estrogen Receptor-Mediated Processes and Show No Antiestrogenicity in Cultured Breast Cancer Cells.

Mäkelä, S., Davis, V., Tally, W. C., et al. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102572 · Cited by 187 · see citing works

Monoclonal antibodies as probes for estrogen receptor detection and characterization

Greene, G. L., & Jensen, E. V. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90045-0 · Cited by 179 · see citing works

Cytoplasmic estrogen receptors in rat brain: immunocytochemical evidence using three antibodies with distinct epitopes.

Blaustein, J. D. (1992) · Endocrinology · doi:10.1210/endo.131.3.1380440 · Cited by 168 · see citing works

Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue

Brolin, J., Ekman, P., & Skoog, L. K. (1992) · The Prostate · doi:10.1002/pros.2990200404 · Cited by 150 · see citing works

Binding Affinity and Specificity of the Estrogen Receptor of the Rat Uterus and Anterior Pituitary

Notides, A. C. (1970) · Endocrinology · doi:10.1210/endo-87-5-987 · Cited by 127 · see citing works

Tamoxifen: Teaching an old drug new tricks?

Grainger, D. J., & Metcalfe, J. C. (1996) · Nature Medicine · doi:10.1038/nm0496-381 · Cited by 125 · see citing works

The specificity of the estrogen receptor of human uterus

Hähnel, R., Twaddle, E., & Ratajczak, T. (1973) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(73)90076-9 · Cited by 121 · see citing works

CHEMICAL STRUCTURE OF STEROIDS IN RELATION TO PROMOTION OF GROWTH OF THE VAGINA AND UTERUS OF THE HYPOPHYSECTOMIZED RAT

Huggins, C., Jensen, E. V., & Cleveland, A. S. (1954) · The Journal of Experimental Medicine · doi:10.1084/jem.100.3.225 · Cited by 120 · see citing works

Estrogen target tissue determines alternative promoter utilization of the human estrogen receptor gene in osteoblasts and tumor cell lines

Grandien, K., Bäckdahl, M., Ljunggren, Ö., Gustafsson, J., & Berkenstam, A. L. (1995) · Endocrinology · doi:10.1210/endo.136.5.7720671 · Cited by 103 · see citing works

High-affinity binding of oestradiol-17β by cytosols from testis interstitial tissue, pituitary, adrenal, liver and accessory sex glands of the male rat

Beurden-Lamers, W. M. O. V., Brinkmann, A. O., Mulder, E., et al. (1974) · Biochemical Journal · doi:10.1042/bj1400495 · Cited by 99 · see citing works

The role of ligand in estrogen receptor regulation of gene expression

Murdoch, F. E., & Gorski, J. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90114-8 · Cited by 84 · see citing works

Evidence and Characterization of the Binding of Two3H-Labeled Androgens to the Estrogen Receptor*

Garcia, M., & Rochefort, H. (1979) · Endocrinology · doi:10.1210/endo-104-6-1797 · Cited by 82 · see citing works

Strategy and Tactics in Receptor Binding Studies

Hulme, E. C., & Birdsall, N. J. M. (1992) · doi:10.1093/oso/9780199630905.003.0004 · Cited by 75 · see citing works

Analysis of the Structural Core of the Human Estrogen Receptor Ligand Binding Domain by Selective Proteolysis/Mass Spectrometric Analysis

Seielstad, D. A., Carlson, K. E., Kushner, P. J., et al. (1995) · Biochemistry · doi:10.1021/bi00039a016 · Cited by 72 · see citing works

Interaction of 16 alpha-[125I]iodo-estradiol with estrogen receptor and other steroid-binding proteins.

Hochberg, R. B., & Rosner, W. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.1.328 · Cited by 62 · see citing works

Localization of DNase I hypersensitive sites in the human oestrogen receptor gene correlates with the transcriptional activity of two differentially used promoters

Grandien, K., Berkenstam, A. L., Nilsson, S., & Gustafsson, J.-Å. (1993) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0100269 · Cited by 51 · see citing works

Receptors for Androgen and Estrogen in the Rat Lung*

MORISHIGE, W. K., & UETAKE, C.-A. (1978) · Endocrinology · doi:10.1210/endo-102-6-1827 · Cited by 42 · see citing works

Actions and Interactions of Δ5-Androstene-3β17β-Diol and 17β-Estradiol in the Immature Rat Uterus

van Doorn, L. G., Poortman, J., Thijssen, J. H. H., & Schwarz, F. (1981) · Endocrinology · doi:10.1210/endo-108-4-1587 · Cited by 36 · see citing works

Lack of estrogenic potential of progesterone- or 19-nor-progesterone-derived progestins as opposed to testosterone or 19-nor-testosterone derivatives on endometrial Ishikawa cells

Botella, J., Duranti, E., Viader, V., et al. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00156-t · Cited by 33 · see citing works

Analysis and Interpretation of Binding at Equilibrium

Wells, J. W. (1992) · doi:10.1093/oso/9780199630905.003.0011 · Cited by 31 · see citing works

Does a radiolabelled ligand bind to a homogeneous population of non-interacting receptor sites?

Swillens, S., Waelbroeck, M., & Champeil, P. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)89007-0 · Cited by 30 · see citing works

Equilibrium hormone binding to human estrogen receptors in highly diluted cell extracts is non-cooperative and has a K of approximately 10 pM

Salomonsson, M., Carlsson, B., & Häggblad, J. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90137-6 · Cited by 30 · see citing works

A novel oestrogen-binding species in rat granulosa cells

Kudolo, G. B., Elder, M. G., & Myatt, L. (1984) · Journal of Endocrinology · doi:10.1677/joe.0.1020083 · Cited by 27 · see citing works

Three radioligands compared for determining cytoplasmic estrogen-receptor content of human breast carcinomas.

Pieslor, P. C., Gibson, R. E., Eckelman, W. C., et al. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.3.532 · Cited by 7 · see citing works

Rapid and sensitive detection of oestrogen receptors in cells and tissue sections by autoradiography with125I-oestradiol

Berns, E. M. J. J., ROMMERTS, F. F. G., & Mulder, E. (1985) · The Histochemical Journal · doi:10.1007/bf01002501 · Cited by 5 · see citing works

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203 · see citing works

Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects –A review

Shahidi, F., & Ambigaipalan, P. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.018 · Cited by 3,081 · see citing works

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045 · see citing works

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

Paech, K., Webb, P., Kuiper, G. G. J. M., Nilsson, S., Gustafsson, J.-Å., Kushner, P. J., & Scanlan, T. S. (1997) · Science · doi:10.1126/science.277.5331.1508 · Cited by 1,861 · see citing works

Estrogen receptors: how do they signal and what are their targets

Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857 · see citing works

The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones

Setchell, K. D. R., Brown, N. M., & Lydeking-Olsen, E. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3577 · Cited by 1,209 · see citing works

Microglial cell origin and phenotypes in health and disease

Saijo, K., & Glass, C. K. (2011) · Nature Reviews Immunology · doi:10.1038/nri3086 · Cited by 1,100 · see citing works

Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

Dupont, S., Krust, A., Gansmuller, A., Dierich, A., Chambon, P., & Mark, M. (2000) · Development · doi:10.1242/dev.127.19.4277 · Cited by 1,064 · see citing works

Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse

Couse, J. F., Lindzey, J., Grandien, K., Gustafsson, J.-A., & Korach, K. S. (1997) · Endocrinology · doi:10.1210/endo.138.11.5496 · Cited by 978 · see citing works

Human skin pigmentation: Melanocytes modulate skin color in response to stress

Costin, G.-E., & Hearing, V. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-6649rev · Cited by 976 · see citing works

Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators

Smith, C. L., & O’Malley, B. W. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0023 · Cited by 931 · see citing works

In vitro molecular mechanisms of bisphenol A action.

Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.010 · Cited by 920 · see citing works

Estrogen production and action

Nelson, L. R., & Bulun, S. E. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.117432 · Cited by 834 · see citing works

International Union of Pharmacology. LXIV. Estrogen Receptors

Dahlman-Wright, K., Cavailles, V., Fuqua, S. A., Jordan, V. C., Katzenellenbogen, J. A., Korach, K. S., Maggi, A., Muramatsu, M., Parker, M. G., & Gustafsson, J.-Å. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.8 · Cited by 583 · see citing works

Cutaneous photodamage, oxidative stress, and topical antioxidant protection

Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.16 · Cited by 544 · see citing works

Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature

Messina, M. (2016) · Nutrients · doi:10.3390/nu8120754 · Cited by 537 · see citing works

Estrogen receptor (ER) β, a modulator of ERα in the uterus

Weihua, Z., Saji, S., Mäkinen, S., Cheng, G., Jensen, E. V., Warner, M., & Gustafsson, J.-Å. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.5936 · Cited by 507 · see citing works

Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse

Hara, Y., Waters, E. M., McEwen, B. S., & Morrison, J. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00036.2014 · Cited by 470 · see citing works

S-Equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora1–4,

Setchell, K. D., Clerici, C., Lephart, E. D., Cole, S. J., Heenan, C., Castellani, D., Wolfe, B. E., Nechemias-Zimmer, L., Brown, N. M., Lund, T. D., et al. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1072 · Cited by 471 · see citing works

Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis

Handa, R. J., & Weiser, M. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.001 · Cited by 408 · see citing works

Endocrine disruptors in the etiology of type 2 diabetes mellitus

Alonso-Magdalena, P., Quesada, I., & Nadal, A. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.56 · Cited by 404 · see citing works

Endocrine activity and developmental toxicity of cosmetic UV filters—an update

Schlumpf, M., Schmid, P., Durrer, S., Conscience, M., Maerkel, K., Henseler, M., Gruetter, M., Herzog, I., Reolon, S., Ceccatelli, R., et al. (2004) · Toxicology · doi:10.1016/j.tox.2004.06.043 · Cited by 410 · see citing works

Structural and Mechanistic Insights into Bisphenols Action Provide Guidelines for Risk Assessment and Discovery of Bisphenol A Substitutes

Delfosse, V., Grimaldi, M., Pons, J.-L., Boulahtouf, A., le Maire, A., Cavailles, V., Labesse, G., Bourguet, W., & Balaguer, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203574109 · Cited by 405 · see citing works

Sexual hormones in human skin

Zouboulis, C., Chen, W.-C., Thornton, M., Qin, K., & Rosenfield, R. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-961807 · Cited by 379 · see citing works

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

Mansouri, K., Abdelaziz, A., Rybacka, A., Roncaglioni, A., Tropsha, A., Varnek, A., Zakharov, A., Worth, A., Richard, A. M., Grulke, C. M., et al. (2016) · Environmental Health Perspectives · doi:10.1289/ehp.1510267 · Cited by 375 · see citing works

Stress facilitates classical conditioning in males, but impairs classical conditioning in females through activational effects of ovarian hormones

Wood, G. E., & Shors, T. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4066 · Cited by 359 · see citing works

Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissues<i>in Vivo</i>through the Use of an ERα-Selective Ligand

Harris, H. A., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (2002) · Endocrinology · doi:10.1210/en.2002-220403 · Cited by 357 · see citing works

Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1

Xue, Q., Lin, Z., Cheng, Y.-H., Huang, C.-C., Marsh, E., Yin, P., Milad, M. P., Confino, E., Reierstad, S., Innes, J., et al. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.061804 · Cited by 346 · see citing works

Relative Enzymatic Activity, Protein Stability, and Tissue Distribution of Human Steroid-Metabolizing UGT2B Subfamily Members**This work was supported by the Medical Research Council of Canada, the Fonds de la Recherche en Sante du Quebec, and Endorecherche.

Turgeon, D., Carrier, J.-S., Lévesque, E., Hum, D. W., & Bélanger, A. (2001) · Endocrinology · doi:10.1210/endo.142.2.7958 · Cited by 333 · see citing works

Molecular Mechanisms of Estrogen Action: Selective Ligands and Receptor Pharmacology

Katzenellenbogen, B. S., Choi, I., Delage-Mourroux, R., Ediger, T. R., Martini, P. G. V., Montano, M., Sun, J., Weis, K., & Katzenellenbogen, J. A. (2000) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(00)00104-7 · Cited by 289 · see citing works

Steroid receptor expression in uterine natural killer cells

Henderson, T. A., Saunders, P. T. K., Moffett-King, A., Groome, N. P., & Critchley, H. O. D. (2003) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2002-021174 · Cited by 283 · see citing works

Comparative distribution of estrogen receptor-α (ER-α) and β (ER-β) mRNA in the rat pituitary, gonad, and reproductive tract

Shughrue, P. J., Lane, M. V., Scrimo, P. J., & Merchenthaler, I. (1998) · Steroids · doi:10.1016/s0039-128x(98)00054-3 · Cited by 285 · see citing works

Quantitative Structure-Activity Relationship of Various Endogenous Estrogen Metabolites for Human Estrogen Receptor α and β Subtypes: Insights into the Structural Determinants Favoring a Differential Subtype Binding

Zhu, B. T., Han, G.-Z., Shim, J.-Y., Wen, Y., & Jiang, X.-R. (2006) · Endocrinology · doi:10.1210/en.2006-0113 · Cited by 271 · see citing works

Estrogen-induced cardiorenal protection: potential cellular, biochemical and molecular mechanisms.

Dubey, R. K., & Jackson, E. K. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.3.f365 · Cited by 263 · see citing works

The Role of Estrogen in Brain and Cognitive Aging

Russell, J. K., Jones, C. K., & Newhouse, P. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00766-9 · Cited by 257 · see citing works

Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis

Shang, Y. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1879 · Cited by 246 · see citing works

Estradiol stimulates transcription of nuclear respiratory factor-1 and increases mitochondrial biogenesis

Mattingly, K. A., Ivanova, M. M., Riggs, K. A., Wickramasinghe, N. S., Barch, M. J., & Klinge, C. M. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0029 · Cited by 243 · see citing works

Sex hormones and their receptors regulate liver energy homeostasis

Shen, M., & Shi, H. (2015) · International Journal of Endocrinology · doi:10.1155/2015/294278 · Cited by 239 · see citing works

Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging

Foster, T. C. (2012) · Hippocampus · doi:10.1002/hipo.20935 · Cited by 231 · see citing works

Sex Hormone Effects on Body Fluid Regulation

Stachenfeld, N. S. (2008) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31817be928 · Cited by 211 · see citing works

Estrogens and age-related memory decline in rodents: What have we learned and where do we go from here?

Frick, K. M. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.08.015 · Cited by 205 · see citing works

Temporal control of gene recombination in astrocytes by transgenic expression of the tamoxifen‐inducible DNA recombinase variant CreERT2

Hirrlinger, P. G., Scheller, A., Braun, C., Hirrlinger, J., & Kirchhoff, F. (2006) · Glia · doi:10.1002/glia.20342 · Cited by 200 · see citing works

An alternate pathway for androgen regulation of brain function: Activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5α-androstane-3β,17β-diol

Handa, R. J., Pak, T. R., Kudwa, A. E., Lund, T. D., & Hinds, L. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.09.012 · Cited by 205 · see citing works

Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: A review of the relevant literature

Messina, M., & Redmond, G. (2006) · Thyroid · doi:10.1089/thy.2006.16.249 · Cited by 200 · see citing works

Expression of genes for estrogen receptors α and β in human articular chondrocytes

Ushiyama, T., Ueyama, H., Inoue, K., Ohkubo, I., & Hukuda, S. (1999) · Osteoarthritis and Cartilage · doi:10.1053/joca.1999.0260 · Cited by 195 · see citing works

Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain

Sinclair, D., Purves-Tyson, T. D., Allen, K. M., & Weickert, C. S. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3415-z · Cited by 191 · see citing works

Molecular insights into androgen actions in male and female reproductive function from androgen receptor knockout models

Walters, K. A., Simanainen, U., & Handelsman, D. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq003 · Cited by 183 · see citing works

Antidepressant effects of ERβ-selective estrogen receptor modulators in the forced swim test

Walf, A. A., Rhodes, M. E., & Frye, C. A. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.03.023 · Cited by 179 · see citing works

Differential expression of estrogen receptor-α and -β and androgen receptor in the ovaries of marmosets and humans

Saunders, P. T. K., Millar, M. R., Williams, K., Macpherson, S., Harkiss, D., Anderson, R. A., Orr, B., Groome, N. P., Scobie, G., & Fraser, H. M. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.4.1098 · Cited by 175 · see citing works

The human forebrain has discrete estrogen receptor α messenger RNA expression: high levels in the amygdaloid complex

Österlund, M. K., Keller, E., & Hurd, Y. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00443-1 · Cited by 174 · see citing works

Oestrogen receptor (ER)-alpha and ER- isoforms in normal endometrial and endometriosis-derived stromal cells

Brandenberger, A. W. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.7.651 · Cited by 165 · see citing works

Estrogen differentially regulates expression of <i>Per1</i> and <i>Per2</i> genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats

Nakamura, T. J., Moriya, T., Inoue, S., Shimazoe, T., Watanabe, S., Ebihara, S., & Shinohara, K. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20677 · Cited by 165 · see citing works

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

Voskuhl, R. R., Itoh, N., Tassoni, A., Matsukawa, M. A., Ren, E., Tse, V., Jang, E., Suen, T. T., & Itoh, Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821306116 · Cited by 162 · see citing works

Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

Mann, G. E., Bonacasa, B., Ishii, T., & Siow, R. C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.012 · Cited by 158 · see citing works

Estrogen as a key regulator of energy homeostasis and metabolic health

Mahboobifard, F., Pourgholami, M. H., Jorjani, M., Dargahi, L., Amiri, M., Sadeghi, S., & Tehrani, F. R. (2022) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2022.113808 · Cited by 154 · see citing works

Estrogen Receptor (ER) β Regulates ERα Expression in Stromal Cells Derived from Ovarian Endometriosis

Trukhacheva, E., Lin, Z., Reierstad, S., Cheng, Y.-H., Milad, M., & Bulun, S. E. (2009) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2008-1466 · Cited by 143 · see citing works

Effect of long-term ovariectomy and estrogen replacement on the expression of estrogen receptor gene in female rats

Mohamed, M., & Abdel-Rahman, A. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1420307 · Cited by 127 · see citing works

Estrogen effects on osmotic regulation of AVP and fluid balance.

Stachenfeld, N. S., & Keefe, D. L. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00192.2002 · Cited by 126 · see citing works

Expression of oestrogen receptor-alpha and -beta in ovarian endometriomata

Fujimoto, J. (1999) · Molecular Human Reproduction · doi:10.1093/molehr/5.8.742 · Cited by 123 · see citing works

Oestrogen receptor <i>β</i> is expressed in adult human skeletal muscle both at the mRNA and protein level

Wiik, A., Glenmark, B., Ekman, M., Esbjörnsson‐Liljedahl, M., Johansson, O., Bodin, K., Enmark, E., & Jansson, E. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.0001-6772.2003.01186.x · Cited by 122 · see citing works

The role of estrogen deficiency in skin ageing and wound healing

Emmerson, E., & Hardman, M. J. (2012) · Biogerontology · doi:10.1007/s10522-011-9322-y · Cited by 118 · see citing works

Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: Results of a meta-analysis

Hamilton-Reeves, J. M., Vazquez, G., Duval, S. J., Phipps, W. R., Kurzer, M. S., & Messina, M. J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.04.038 · Cited by 115 · see citing works

Effect of estrogen deficiency in the male: the ArKO mouse model

Murata, Y., Robertson, K. M., Jones, M. E. E., & Simpson, E. R. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00090-4 · Cited by 111 · see citing works

Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function

Lephart, E. D., Lund, T. D., & Horvath, T. L. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00111-4 · Cited by 111 · see citing works

Estrogen dependent signaling in reproductive tissues—A role for estrogen receptors and estrogen related receptors

Gibson, D. A., & Saunders, P. T. K. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.026 · Cited by 107 · see citing works

Emerging medication for the treatment of male hypogonadism

Corona, G., Rastrelli, G., Vignozzi, L., & Maggi, M. (2012) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2012.683411 · Cited by 93 · see citing works

Effects of genistein exposure on sexually dimorphic behaviors in rats.

Flynn, K. M. (2000) · Toxicological Sciences · doi:10.1093/toxsci/55.2.311 · Cited by 92 · see citing works

Environmental toxins and the impact of other endocrine disrupting chemicals in women's reproductive health

Piazza, M. J., & Urbanetz, A. A. (2019) · JBRA Assisted Reproduction · doi:10.5935/1518-0557.20190016 · Cited by 90 · see citing works

Delivery Strategies for Immune Checkpoint Blockade

Chen, Q., Wang, C., Chen, G., Hu, Q., & Gu, Z. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800424 · Cited by 90 · see citing works

Wild-Type Estrogen Receptor (ERβ1) and the Splice Variant (ERβcx/β2) Are Both Expressed within the Human Endometrium throughout the Normal Menstrual Cycle

Critchley, H. O. D., Henderson, T. A., Kelly, R. W., Scobie, G. S., Evans, L. R., Groome, N. P., & Saunders, P. T. K. (2002) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2002-020502 · Cited by 87 · see citing works

Long-Range Activation of GREB1 by Estrogen Receptor via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells

Sun, J., Nawaz, Z., & Slingerland, J. M. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0082 · Cited by 83 · see citing works

Oestrogen functions in skin and skin appendages

Thornton, M. J. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.3.617 · Cited by 82 · see citing works

Biochemical investigation and gene analysis of equol: A plant and soy‐derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications

Gopaul, R., Knaggs, H. E., & Lephart, E. D. (2012) · BioFactors · doi:10.1002/biof.191 · Cited by 72 · see citing works

The impact of ERα action on muscle metabolism and insulin sensitivity – Strong enough for a man, made for a woman

Hevener, A. L., Zhou, Z., Moore, T. M., Drew, B. G., & Ribas, V. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.06.013 · Cited by 72 · see citing works

Estrogen Receptor-β Mediates Dihydrotestosterone-Induced Stimulation of the Arginine Vasopressin Promoter in Neuronal Cells

Pak, T. R., Chung, W. C. J., Hinds, L. R., & Handa, R. J. (2007) · Endocrinology · doi:10.1210/en.2007-0086 · Cited by 69 · see citing works

Stepping Backward to Improve Assessment of PCB Congener Toxicities

Hansen, L. G. (1998) · Environmental Health Perspectives · doi:10.2307/3433919 · Cited by 336 · see citing works

Distribution and chemical composition of estrogen receptor β neurons in the paraventricular nucleus of the female and male mouse hypothalamus

Oyola, M. G., Thompson, M. K., Handa, A. Z., & Handa, R. J. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24295 · Cited by 53 · see citing works

The pleiotropy of dioxin toxicity — Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles

Furness, S. G. B., & Whelan, F. (2009) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2009.09.004 · Cited by 63 · see citing works

Timing of estradiol treatment after menopause may determine benefit or harm to insulin action

Pereira, R. I., Casey, B. A., Swibas, T. A., Erickson, C. B., Wolfe, P., & Van Pelt, R. E. (2015) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2015-3084 · Cited by 59 · see citing works

Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity

Weigt, C., Hertrampf, T., Zoth, N., Fritzemeier, K. H., & Diel, P. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.12.013 · Cited by 56 · see citing works

Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women

Yildiz, M. F., Kumru, S., Godekmerdan, A., & Kutlu, S. (2005) · International Journal of Gynecology &amp; Obstetrics · doi:10.1016/j.ijgo.2005.05.005 · Cited by 56 · see citing works

Increased aggressive behavior and decreased affiliative behavior in adult male monkeys after long-term consumption of diets rich in soy protein and isoflavones

Simon, N. G., Kaplan, J. R., Hu, S., Register, T. C., & Adams, M. R. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2003.12.005 · Cited by 56 · see citing works

Changes in α-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle

Helena, C. V. V., de Oliveira Poletini, M., Sanvitto, G. L., Hayashi, S., Franci, C. R., & Anselmo-Franci, J. A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06268 · Cited by 53 · see citing works

Endocrine Disruption of Vasopressin Systems and Related Behaviors

Patisaul, H. B. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00134 · Cited by 54 · see citing works

Sex steroids and the kidney: role in renal calcium and phosphate handling

Khalil, R., Kim, N. R., Jardi, F., Vanderschueren, D., Claessens, F., & Decallonne, B. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.11.011 · Cited by 53 · see citing works

The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health

Hevener, A. L., Ribas, V., Moore, T. M., & Zhou, Z. (2020) · Endocrinology · doi:10.1210/endocr/bqz017 · Cited by 54 · see citing works

Estrogen induces estrogen receptor alpha expression and hepatocyte proliferation in the livers of male mice

Uebi, T., Umeda, M., & Imai, T. (2015) · Genes to Cells · doi:10.1111/gtc.12214 · Cited by 52 · see citing works

Neuroendocrine underpinning of social recognition in males and females

Aspesi, D., & Choleris, E. (2022) · Journal of Neuroendocrinology · doi:10.1111/jne.13070 · Cited by 41 · see citing works

Male/female differences in neuroprotection and neuromodulation of brain dopamine

Bourque, M. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00035 · Cited by 40 · see citing works

Effects of early embryonic exposure to genistein on male copulatory behavior and vasotocin system of Japanese quail

Viglietti-Panzica, C., Mura, E., & Panzica, G. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.12.003 · Cited by 37 · see citing works

Androgen glucuronides analysis by liquid chromatography tandem-mass spectrometry: could it raise new perspectives in the diagnostic field of hormone-dependent malignancies?

Kalogera, E., Pistos, C., Provatopoulou, X., Athanaselis, S., Spiliopoulou, C., & Gounaris, A. (2013) · Journal of Chromatography B · doi:10.1016/j.jchromb.2013.09.022 · Cited by 31 · see citing works

The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity

Hevener, A. L., Zhou, Z., Drew, B. G., & Ribas, V. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-70178-3_13 · Cited by 23 · see citing works

DHEA – a precursor of ERβ ligands

Warner, M., & Gustafsson, J.-A. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.08.003 · Cited by 22 · see citing works

Effects of dietary phytoestrogens on plasma testosterone and triiodothyronine (T3) levels in male goat kids

Gunnarsson, D., Selstam, G., Ridderstråle, Y., Holm, L., Ekstedt, E., & Madej, A. (2009) · Acta veterinaria Scandinavica · doi:10.1186/1751-0147-51-51 · Cited by 21 · see citing works

Sulfation of estradiol in human epidermal keratinocyte

Kushida, A., Hattori, K., Yamaguchi, N., Kobayashi, T., Date, A., & Tamura, H. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1147 · Cited by 17 · see citing works

Effects of estrogen receptor α and β on the expression of visfatin and retinol-binding protein 4 in 3T3-L1 adipocytes

JUNG, U. S., JEONG, K. J., KANG, J. K., YI, K., SHIN, J.-H., SEO, H. S., KIM, T., KIM, S.-H., & HUR, J.-Y. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1440 · Cited by 15 · see citing works

Comparison of the effects of add-back therapy with various natural oestrogens on bone metabolism in rats administered a long-acting gonadotrophin-releasing hormone agonist

Wang, Y., Yano, T., Kikuchi, A., Yano, N., Matsumi, H., Ando, K., Kasai, Y., Watanabe, M., Okagaki, R., Osuga, Y., et al. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650467 · Cited by 13 · see citing works

High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens

Kirker, M. R., Gallagher, K. M., Witt-Enderby, P. A., & Davis, V. L. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.04.002 · Cited by 10 · see citing works

Presurgical Oral Tamoxifen vs Transdermal 4-Hydroxytamoxifen in Women With Ductal Carcinoma In Situ: A Randomized Clinical Trial

Khan, S. A., Mi, X., Xu, Y., Blanco, L. Z., Akasha, A. M., Pilewskie, M., Degnim, A. C., AlHilli, Z., Amin, A. L., Hwang, E. S., et al. (2023) · JAMA Surgery · doi:10.1001/jamasurg.2023.5113 · Cited by 9 · see citing works

The antidepressant-like effect of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane involves a regulation of β-type estrogen receptors

Espallergues, J., Temsamani, J., Laruelle, C., Urani, A., & Maurice, T. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2053-y · Cited by 8 · see citing works

Estrogen receptor beta and G protein-coupled estrogen receptor 1 are involved in the acute estrogenic regulation of arginine-vasopressin immunoreactive levels in the supraoptic and paraventricular hypothalamic nuclei of female rats

Lagunas, N., Marraudino, M., Amorim, M. A. R., Pinos, H., Collado, P., Panzica, G., García‐Segura, L. M., & Grassi, D. (2019) · Brain Research · doi:10.1016/j.brainres.2019.02.002 · Cited by 16 · see citing works

Estrogen receptor α-induced cholecystokinin type A receptor expression in the female mouse pituitary

Kim, H. J., Gieske, M. C., Hudgins‐Spivey, S., Kim, B. G., Krust, A., Chambon, P., & Ko, C. J. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0358 · Cited by 9 · see citing works

Regulation of Estrogen Receptor-β Expression in the Female Rat Hypothalamus: Differential Effects of Dexamethasone and Estradiol

Suzuki, S., & Handa, R. J. (2004) · Endocrinology · doi:10.1210/en.2003-1688 · Cited by 74 · see citing works

Regulation of estrogen and progestin receptor concentrations in an experimental rat prostatic carcinoma by estrogen, antiestrogen, and progesterone.

Mobbs, B. G., Johnson, I. E., DeSombre, E. R., et al. (1987) · PubMed · Cited by 11 · see citing works

Estrogen Receptor β/α Ratio Predicts Response of Pancreatic Cancer Cells to Estrogens and Phytoestrogens

Konduri, S., & Schwarz, R. E. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.10.015 · Cited by 62 · see citing works