The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis
Abstract
Mutations that eliminate KatG catalase-peroxidase activity prevent activation of isoniazid and are a major mechanism of resistance to this principal drug for the treatment of Mycobacterium tuberculosis infections. However, the loss of KatG activity in clinical isolates seemed paradoxical because KatG is considered an important factor for the survival of the organism. Expression of either KatG or the recently identified alkyl hydroperoxidase AhpC was sufficient to protect bacilli against the toxic effects of organic peroxides. To survive during infection, isoniazid-resistant KatG mutants have apparently compensated for the loss of KatG catalase-peroxidase activity by a second mutation, resulting in hyperexpression of AhpC.
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Citations
Cites
The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
Zhang, Y., Heym, B., Allen, B., Young, D., & Cole, S. (1992) · Nature · doi:10.1038/358591a0 · Cited by 1,299
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Almeida Da Silva, P. E., & Palomino, J. C. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr173 · Cited by 532
Kublin, J. G., Cortese, J. F., Njunju, E. M., G. Mukadam, R. A., Wirima, J. J., Kazembe, P. N., Djimdé, A. A., Kouriba, B., Taylor, T. E., & Plowe, C. V. (2003) · The Journal of Infectious Diseases · doi:10.1086/375419 · Cited by 508
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Casali, N., Nikolayevskyy, V., Balabanova, Y., Harris, S. R., Ignatyeva, O., Kontsevaya, I., Corander, J., Bryant, J., Parkhill, J., Nejentsev, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.2878 · Cited by 473
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Metadata
- Authors
- Sherman, D. R., Mdluli, K., Hickey, M. J., Arain, T. M., Morris, S. L., Barry, C. E., & Stover, C. K.
- Venue
- Science
- Published
- 1996-06-14
- Volume
- 272
- Issue
- 5268
- Pages
- 1641-1643
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995016187
- Cited by
- 436
- References
- 1
- FWCI
- 19.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sherman, D. R., Mdluli, K., Hickey, M. J., Arain, T. M., Morris, S. L., Barry, C. E., & Stover, C. K. (1996). Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis. Science. https://doi.org/10.1126/science.272.5268.1641
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
