The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Reemergence of Chloroquine‐Sensitive Plasmodium falciparum Malaria after Cessation of Chloroquine Use in Malawi
Abstract
In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria. To determine whether withdrawal of chloroquine can lead to the reemergence of chloroquine sensitivity, the prevalence of the pfcrt 76T molecular marker for chloroquine-resistant Plasmodium falciparum malaria was retrospectively measured in Blantyre, Malawi. The prevalence of the chloroquine-resistant pfcrt genotype decreased from 85% in 1992 to 13% in 2000. In 2001, chloroquine cleared 100% of 63 asymptomatic P. falciparum infections, no isolates were resistant to chloroquine in vitro, and no infections with the chloroquine-resistant pfcrt genotype were detected. A concerted national effort to withdraw chloroquine from use has been followed by a return of chloroquine-sensitive falciparum malaria in Malawi. The reintroduction of chloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives remain unavailable.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fidock, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00084-8 · Cited by 1,456
A Molecular Marker for Chloroquine-Resistant Falciparum Malaria
Djimdé, A., Doumbo, O. K., Cortese, J. F., Kayentao, K., Doumbo, S., Diourté, Y., Coulibaly, D., Dicko, A., Su, X.-Z., Nomura, T., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101253440403 · Cited by 1,010
Self-citationPgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
Reed, M. B., Saliba, K. J., Caruana, S. R., Kirk, K., & Cowman, A. F. (2000) · Nature · doi:10.1038/35002615 · Cited by 866
Wellems, T. E., & Plowe, C. V. (2001) · The Journal of Infectious Diseases · doi:10.1086/322858 · Cited by 807
Self-citationChloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations
Sidhu, A. B. S., Verdier-Pinard, D., & Fidock, D. A. (2002) · Science · doi:10.1126/science.1074045 · Cited by 720
Levin, B. R., Perrot, V., & Walker, N. (2000) · Genetics · doi:10.1093/genetics/154.3.985 · Cited by 624
White, N., Nosten, F., Looareesuwan, S., Watkins, W., Marsh, K., Snow, R., Kokwaro, G., Ouma, J., Hien, T., Molyneux, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)07367-x · Cited by 543
Self-citationKublin, J. G., Dzinjalamala, F. K., Kamwendo, D. D., Malkin, E. M., Cortese, J. F., Martino, L. M., Mukadam, R. A. G., Rogerson, S. J., Lescano, A. G., Molyneux, M. E., et al. (2002) · The Journal of Infectious Diseases · doi:10.1086/338566 · Cited by 523
Self-citationEnne, V. I., Livermore, D. M., Stephens, P., & Hall, L. M. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04519-0 · Cited by 486
Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis
Sherman, D. R., Mdluli, K., Hickey, M. J., Arain, T. M., Morris, S. L., Barry, C. E., & Stover, C. K. (1996) · Science · doi:10.1126/science.272.5268.1641 · Cited by 436
Cited by
Price, R. N., Uhlemann, A.-C., van Vugt, M., Brockman, A., Hutagalung, R., Nair, S., Nash, D., Singhasivanon, P., Anderson, T. J. C., Krishna, S., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/503423 · Cited by 317
Reducing the burden of malaria in pregnancy by preventive strategies
Menéndez, C., D'Alessandro, U., & ter Kuile, F. O. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70024-5 · Cited by 188
Intermittent preventive treatment of malaria in pregnancy: at the crossroads of public health policy
Chico, R. M., & Chandramohan, D. (2011) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2011.02765.x · Cited by 38
Pregnancy-associated Malaria, Challenges and Prospects in Sub-Saharan Africa
Aguzie, I. O. N. (2018) · Clinics in Mother and Child Health · doi:10.4172/2090-7214.1000282 · Cited by 13
Metadata
- Authors
- Kublin, J. G., Cortese, J. F., Njunju, E. M., G. Mukadam, R. A., Wirima, J. J., Kazembe, P. N., Djimdé, A. A., Kouriba, B., Taylor, T. E., & Plowe, C. V.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-06-15
- Volume
- 187
- Issue
- 12
- Pages
- 1870-1875
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2132831164
- Cited by
- 508
- References
- 24
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Reemergence of Chloroquine‐Sensitive Plasmodium falciparum Malaria after Cessation of Chloroquine Use in Malawi. https://app.cochat.ai/papers/10.1086/375419
- The paper
- Kublin, J. G., Cortese, J. F., Njunju, E. M., G. Mukadam, R. A., Wirima, J. J., Kazembe, P. N., Djimdé, A. A., Kouriba, B., Taylor, T. E., & Plowe, C. V. (2003). Reemergence of Chloroquine‐Sensitive Plasmodium falciparum Malaria after Cessation of Chloroquine Use in Malawi. The Journal of Infectious Diseases. https://doi.org/10.1086/375419
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
