The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Adenosine Diphosphate as an Intracellular Regulator of Insulin Secretion
Abstract
Adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channels couple the cellular metabolic state to electrical activity and are a critical link between blood glucose concentration and pancreatic insulin secretion. A mutation in the second nucleotide-binding fold (NBF2) of the sulfonylurea receptor (SUR) of an individual diagnosed with persistent hyperinsulinemic hypoglycemia of infancy generated K ATP channels that could be opened by diazoxide but not in response to metabolic inhibition. The hamster SUR, containing the analogous mutation, had normal ATP sensitivity, but unlike wild-type channels, inhibition by ATP was not antagonized by adenosine diphosphate (ADP). Additional mutations in NBF2 resulted in the same phenotype, whereas an equivalent mutation in NBF1 showed normal sensitivity to MgADP. Thus, by binding to SUR NBF2 and antagonizing ATP inhibition of K ATP channels, intracellular MgADP may regulate insulin secretion.
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Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
Thomas, P. M., Cote, G. J., Wohllk, N., Haddad, B., Mathew, P. M., Rabl, W., Aguilar-Bryan, L., Gagel, R. F., & Bryan, J. (1995) · Science · doi:10.1126/science.7716548 · Cited by 806
Self-citation
Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Activating Mutations in the ABCC8 Gene in Neonatal Diabetes Mellitus
Babenko, A. P., Polak, M., Cavé, H., Busiah, K., Czernichow, P., Scharfmann, R., Bryan, J., Aguilar-Bryan, L., Vaxillaire, M., & Froguel, P. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055068 · Cited by 655
Self-citationThe Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion
MacDonald, P. E., El-kholy, W., Riedel, M. J., Salapatek, A. M. F., Light, P. E., & Wheeler, M. B. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s434 · Cited by 590
Toward Understanding the Assembly and Structure of KATPChannels
AGUILAR-BRYAN, L., CLEMENT, J. P., GONZALEZ, G., KUNJILWAR, K., BABENKO, A., & BRYAN, J. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.227 · Cited by 540
Self-citationSulfonylurea Stimulation of Insulin Secretion
Proks, P., Reimann, F., Green, N., Gribble, F., & Ashcroft, F. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s368 · Cited by 510
Metadata
- Authors
- Nichols, C. G., Shyng, S.-L., Nestorowicz, A., Glaser, B., Clement, J. P., Gonzalez, G., Aguilar-Bryan, L., Permutt, M. A., & Bryan, J.
- Venue
- Science
- Published
- 1996-06-21
- Volume
- 272
- Issue
- 5269
- Pages
- 1785-1787
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022446120
- Cited by
- 524
- References
- 2
- FWCI
- 51.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nichols, C. G., Shyng, S.-L., Nestorowicz, A., Glaser, B., Clement, J. P., Gonzalez, G., Aguilar-Bryan, L., Permutt, M. A., & Bryan, J. (1996). Adenosine Diphosphate as an Intracellular Regulator of Insulin Secretion. Science. https://doi.org/10.1126/science.272.5269.1785
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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