The DOI matches its Crossref record.
Cytoplasmic Tail-Dependent Localization of CD1b Antigen-Presenting Molecules to MIICs
Abstract
CD1 proteins have been implicated as antigen-presenting molecules for T cell-mediated immune responses, but their intracellular localization and trafficking remain uncharacterized. CD1b, a member of this family that presents microbial lipid antigens of exogenous origin, was found to localize to endocytic compartments that included the same specialized subset of endosomes in which major histocompatibility complex (MHC) class II molecules are proposed to bind endocytosed antigens. Unlike MHC class II molecules, which traffic to antigen-loading endosomal compartments [MHC class II compartments (MIICs)] primarily as a consequence of their association with the invariant chain, localization of CD1b to these compartments was dependent on a tyrosine-based motif in its own cytoplasmic tail.
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Cited by
Unconventional Methods for Fabricating and Patterning Nanostructures
Xia, Y., Rogers, J. A., Paul, K. E., & Whitesides, G. M. (1999) · Chemical Reviews · doi:10.1021/cr980002q · Cited by 1,538
Prigozy, T. I., Sieling, P. A., Clemens, D., Stewart, P. L., Behar, S. M., Porcelli, S. A., Brenner, M. B., Modlin, R. L., & Kronenberg, M. (1997) · Immunity · doi:10.1016/s1074-7613(00)80425-2 · Cited by 337
Self-citationBurdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., & Kronenberg, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3271 · Cited by 334
Saposin C is required for lipid presentation by human CD1b
Winau, F., Schwierzeck, V., Hurwitz, R., Remmel, N., Sieling, P. A., Modlin, R. L., Porcelli, S. A., Brinkmann, V., Sugita, M., Sandhoff, K., et al. (2004) · Nature Immunology · doi:10.1038/ni1035 · Cited by 168
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Metadata
- Authors
- Sugita, M., Jackman, R. M., van Donselaar, E., Behar, S. M., Rogers, R. A., Peters, P. J., Brenner, M. B., & Porcelli, S. A.
- Venue
- Science
- Published
- 1996-07-19
- Volume
- 273
- Issue
- 5273
- Pages
- 349-352
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052178043
- Cited by
- 225
- References
- 0
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sugita, M., Jackman, R. M., van Donselaar, E., Behar, S. M., Rogers, R. A., Peters, P. J., Brenner, M. B., & Porcelli, S. A. (1996). Cytoplasmic Tail-Dependent Localization of CD1b Antigen-Presenting Molecules to MIICs. Science. https://doi.org/10.1126/science.273.5273.349
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
