Saposin C is required for lipid presentation by human CD1b
Abstract
Lipids from Mycobacterium tuberculosis are presented through CD1 proteins to T lymphocytes in humans, but the accessory molecules required for antigen loading and presentation remain unidentified. Here we show that fibroblasts deficient in sphingolipid activator proteins (SAPs) transfected with CD1b failed to activate lipid-specific T cells. However, the T cell response was restored when fibroblasts were reconstituted with SAP-C but not other SAPs. Lipid antigen and SAP-C colocalized in lysosomal compartments, and liposome assays showed that SAP-C efficiently extracts antigen from membranes. Coprecipitation demonstrated direct molecular interaction between SAP-C and CD1b. We propose a model in which SAP-C exposes lipid antigens from intralysosomal membranes for loading onto CD1b. Thus, SAP-C represents a missing link in antigen presentation of lipids through CD1b to human T cells.
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Lysosomal lipid transfer proteins such as the four active saposins generated from pro-saposin by proteolytic cleavage are essential for glyco-lipid degradation and glyco-lipid homeostasis, in addition to their function in processing and presentation of lipid antigens by CD1b molecules in DC.
“Lysosomal lipid transfer proteins (LTPs), such as the four active saposins generated from pro-saposin by proteolytic cleavage, are essential for glyco-lipid degradation in lysosomes and glyco-lipid homeostasis, in addition to their immunologically relevant function in processing and presentation of lipid antigens by CD1b molecules in DC (41, 42).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [42]
Cites
CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens
Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T. T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., et al. (1995) · Science · doi:10.1126/science.7542404 · Cited by 727 · see citing works
Self-citationTHE CD1 SYSTEM: Antigen-Presenting Molecules for T Cell Recognition of Lipids and Glycolipids
Porcelli, S. A., & Modlin, R. L. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.297 · Cited by 697 · see citing works
Self-citationRecognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyte
Porcelli, S. A., Brenner, M. B., Greenstein, J. L., Terhorst, C., Balk, S. P., & Bleicher, P. A. (1989) · Nature · doi:10.1038/341447a0 · Cited by 530 · see citing works
Self-citationCD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
Moody, D. B., Ulrichs, T., Mühlecker, W., Young, D. C., Gurcha, S. S., Grant, E. P., Rosat, J., Brenner, M. B., Costello, C. E., Besra, G. S., et al. (2000) · Nature · doi:10.1038/35009119 · Cited by 456 · see citing works
Self-citationStructural Requirements for Glycolipid Antigen Recognition by CD1b-Restricted T Cells
Moody, D. B., Reinhold, B. B., Guy, M. R., Beckman, E. M., Frederique, D. E., Furlong, S. T., Ye, S., Reinhold, V. N., Sieling, P. A., Modlin, R. L., et al. (1997) · Science · doi:10.1126/science.278.5336.283 · Cited by 441 · see citing works
Self-citationPrigozy, T. I., Sieling, P. A., Clemens, D., Stewart, P. L., Behar, S. M., Porcelli, S. A., Brenner, M. B., Modlin, R. L., & Kronenberg, M. (1997) · Immunity · doi:10.1016/s1074-7613(00)80425-2 · Cited by 337 · see citing works
Self-citationCalabi, F., Jarvis, J. M., Martin, L. H., & Milstein, C. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190211 · Cited by 262 · see citing works
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains
Gadola, S. D., Zaccai, N. R., Harlos, K., Shepherd, D., Castro-Palomino, J. C., Ritter, G., Schmidt, R. R., Jones, E. Y., & Cerundolo, V. (2002) · Nature Immunology · doi:10.1038/ni821 · Cited by 252 · see citing works
Coding of Two Sphingolipid Activator Proteins (SAP-1 and SAP-2) by Same Genetic Locus
O’Brien, J. S., Kretz, K. A., Dewji, N. N., Wenger, D. A., Esch, F. S., & Fluharty, A. L. (1988) · Science · doi:10.1126/science.2842863 · Cited by 246 · see citing works
Is the development of a new tuberculosis vaccine possible?
Kaufmann, S. H. E. (2000) · Nature Medicine · doi:10.1038/79631 · Cited by 225 · see citing works
Self-citationCytoplasmic Tail-Dependent Localization of CD1b Antigen-Presenting Molecules to MIICs
Sugita, M., Jackman, R. M., van Donselaar, E. G., Behar, S. M., Rogers, R. A., Peters, P. J., Brenner, M. B., & Porcelli, S. A. (1996) · Science · doi:10.1126/science.273.5273.349 · Cited by 222 · see citing works
Self-citationPresentation of the Same Glycolipid by Different CD1 Molecules
Shamshiev, A. T., Gober, H. J., Donda, A., Mazorra, Z., Mori, L., & Libero, G. D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011963 · Cited by 215 · see citing works
HARZER, K., Paton, B. C., Poulos, A., Kustermann‐Kuhn, B., Roggendorf, W., Grisar, T., & Popp, M. (1989) · European Journal of Pediatrics · doi:10.1007/bf02024331 · Cited by 199 · see citing works
Intracellular pathways of CD1 antigen presentation
Moody, D. B., & Porcelli, S. A. (2003) · Nature reviews. Immunology · doi:10.1038/nri979 · Cited by 194 · see citing works
Self-citationT-cell release of granulysin contributes to host defense in leprosy
Ochoa, M. T., Stenger, S., Sieling, P. A., Thoma-Uszynski, S., Sabet, S., Cho, S., Krensky, A. M., Röllinghoff, M., Sarno, E. N., Burdick, A. E., et al. (2001) · Nature Medicine · doi:10.1038/84620 · Cited by 174 · see citing works
Self-citationFailure of Trafficking and Antigen Presentation by CD1 in AP-3-Deficient Cells
Sugita, M., Cao, X., Watts, G. F. M., Rogers, R. A., Bonifacino, J. S., & Brenner, M. B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00311-4 · Cited by 172 · see citing works
Self-citationLysosomal Degradation on Vesicular Membrane Surfaces
Wilkening, G., Linke, T. A., & Sandhoff, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30271 · Cited by 155 · see citing works
Self-citationLipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation
Moody, D. B., Briken, V., Cheng, T., Roura‐Mir, C., Guy, M. R., Geho, D. H., Tykocinski, M. L., Besra, G. S., & Porcelli, S. A. (2002) · Nature Immunology · doi:10.1038/ni780 · Cited by 149 · see citing works
Self-citationSchnabel, D., Schröder, M., Fürst, W., Klein, A., HURWITZ, R. M., Zenk, T. S., Weber, J., HARZER, K., Paton, B. C., & Poulos, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50733-5 · Cited by 148 · see citing works
Self-citationMoody, D. B., Guy, M. R., Grant, E. P., Cheng, T., Brenner, M. B., Besra, G. S., & Porcelli, S. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.965 · Cited by 148 · see citing works
Self-citationJackman, R. M., Stenger, S., Lee, A., Moody, D. B., Rogers, R. A., Niazi, K., Sugita, M., Modlin, R. L., Peters, P. J., & Porcelli, S. A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80539-7 · Cited by 142 · see citing works
Self-citationSchaible, U. E., Hagens, K., Fischer, K., Collins, H., & Kaufmann, S. H. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4843 · Cited by 117 · see citing works
Self-citationSaposins and Their Interaction with Lipids
Vaccaro, A. M., Salvioli, R., Tatti, M., & Ciaffoni, F. (1999) · Neurochemical Research · doi:10.1023/a:1022530508763 · Cited by 112 · see citing works
Vaccaro, A. M., Ciaffoni, F., Tatti, M., Salvioli, R., Barca, A., Tognozzi, D., & Scerch, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30576 · Cited by 96 · see citing works
Intracellular trafficking pathway of newly synthesized CD1b molecules
Briken, V., Jackman, R. M., Dasgupta, S., Höning, S., & Porcelli, S. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.825 · Cited by 95 · see citing works
Self-citationSieling, P. A., Ochoa, M. T., Jullien, D., Leslie, D. S., Sabet, S., Rosat, J., Burdick, A. E., Rea, T. H., Brenner, M. B., Porcelli, S. A., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.9.4790 · Cited by 89 · see citing works
Self-citationVielhaber, G., HURWITZ, R. M., & Sandhoff, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.32438 · Cited by 78 · see citing works
Self-citationInteraction of saposins, acidic lipids, and glucosylceramidase.
Morimoto, S., Kishimoto, Y., Tomich, J. M., Weiler, S., Ohashi, T., Barranger, J. A., Kretz, K. A., & O′Brien, J. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39921-1 · Cited by 76 · see citing works
Schuette, C. G., Pierstorff, B., Huettler, S., & Sandhoff, K. (2001) · Glycobiology · doi:10.1093/glycob/11.6.81r · Cited by 63 · see citing works
Self-citationEffect of Saposins A and C on the Enzymatic Hydrolysis of Liposomal Glucosylceramide
Vaccaro, A. M., Tatti, M., Ciaffoni, F., Salvioli, R., Barca, A., & Scerch, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16862 · Cited by 60 · see citing works
Structure, function and biogenesis of the mycobacterial cell wall
Brennan, P. J., & Besra, G. S. (1997) · Biochemical Society Transactions · doi:10.1042/bst0250188 · Cited by 41 · see citing works
CD1-restricted antigen presentation: an oily matter
Joyce, S., & Kaer, L. V. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00012-2 · Cited by 41 · see citing works
19 Studying trafficking of intracellular pathogens in antigen-presenting cells
Schaible, U. E., & Kaufmann, S. H. E. (2002) · Methods in microbiology · doi:10.1016/s0580-9517(02)31020-1 · Cited by 17 · see citing works
Self-citationStructural requirements for lysosomal targeting of the prosaposin precursor protein
Ham, D. (2003) · Cell Biology International · doi:10.1016/s1065-6995(03)00124-0 · Cited by 3 · see citing works
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Vaccaro, A. M., Motta, M., Tatti, M., Scarpa, S., Masuelli, L., Bhat, M., Vanier, M. T., Tylki‐Szymańska, A., & Salvioli, R. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq204 · Cited by 105 · see citing works
Immune system irregularities in lysosomal storage disorders
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Matsuda, J., Kido, M., Tadano‐Aritomi, K., Ishizuka, I., Tominaga, K., Toida, K., Takeda, E., Suzuki, K., & Kuroda, Y. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh281 · Cited by 94 · see citing works
Rossmann, M., Schultz‐Heienbrok, R., Behlke, J., Remmel, N., Alings, C., Sandhoff, K., Saenger, W., & Maier, T. (2008) · Structure · doi:10.1016/j.str.2008.02.016 · Cited by 89 · see citing works
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Self-citationLocatelli‐Hoops, S., Remmel, N., Klingenstein, R., Breiden, B., Rossocha, M., Schoeniger, M., Koenigs, C., Saenger, W., & Sandhoff, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607281200 · Cited by 73 · see citing works
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Four pathways of CD1 antigen presentation to T cells
Moody, D. B., & Cotton, R. N. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.07.013 · Cited by 52 · see citing works
Sagiv, Y., Bai, L., Wei, D. G., Agami, R., Savage, P. B., Teyton, L., & Bendelac, A. S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061568 · Cited by 52 · see citing works
Kiss, R. S., Ma, Z., Nakada‐Tsukui, K., Brugnera, E., Vassiliou, G., McBride, H. M., Ravichandran, K. S., & Marcel, Y. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600621200 · Cited by 51 · see citing works
Role of lipid trimming and CD1 groove size in cellular antigen presentation
Cheng, T., Relloso, M., Rhijn, I. V., Young, D. C., Besra, G. S., Briken, V., Zajonc, D. M., Wilson, I. A., Porcelli, S. A., & Moody, D. B. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601185 · Cited by 51 · see citing works
Self-citationMoody, D. B. (2006) · Nature Immunology · doi:10.1038/ni1368 · Cited by 50 · see citing works
Kaufmann, S. H. E. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.028258 · Cited by 50 · see citing works
Self-citationRyser, S., Nollet, M. S., Gauthier, B. E., Hernandez, D. R., Roye, O., Hohl, D., German, B. J., Holzwarth, J. A., & Moodycliffe, A. M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.300 · Cited by 48 · see citing works
The processing and presentation of lipids and glycolipids to the immune system
Vartabedian, V. F., Savage, P. B., & Teyton, L. (2016) · Immunological Reviews · doi:10.1111/imr.12431 · Cited by 48 · see citing works
pH-Dependent Interdomain Tethers of CD1b Regulate Its Antigen Capture
Relloso, M., Cheng, T., Im, J. S., Parisini, E., Roura‐Mir, C., Debono, C. A., Zajonc, D. M., Murga, L. F., Ondrechen, M. J., Wilson, I. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.017 · Cited by 48 · see citing works
Self-citationThe CD1 size problem: lipid antigens, ligands, and scaffolds
Ly, D., & Moody, D. B. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1603-6 · Cited by 47 · see citing works
Hava, D. L., van der Wel, N. N., Cohen, N. R., Dascher, C. C., Houben, D., León, L., Agarwal, S. K., Sugita, M., van Zon, M., Kent, S. C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804681105 · Cited by 47 · see citing works
Self-citationThe evolved functions of CD1 during infection
Kasmar, A. G., Rhijn, I. V., & Moody, D. B. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.022 · Cited by 47 · see citing works
Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase
Abdul-Hammed, M., Breiden, B., Schwarzmann, G. O. H., & Sandhoff, K. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m073510 · Cited by 47 · see citing works
Self-citationAntigen presentation by CD1 molecules and the generation of lipid-specific T cell immunity
Bricard, G., & Porcelli, S. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7007-0 · Cited by 47 · see citing works
Self-citationIdentification of Self-lipids Presented by CD1c and CD1d Proteins
Haig, N. A., Guan, Z., Li, D., McMichael, A. J., Raetz, C. R. H., & Xu, X. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267948 · Cited by 46 · see citing works
Dowds, C. M., Kornell, S.-C., Blumberg, R. S., & Zeißig, S. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0220 · Cited by 44 · see citing works
Salio, M., Ghadbane, H., Dushek, O., Shepherd, D., Cypen, J., Gileadi, U., Aichinger, M. C., Napolitani, G., Qi, X., van der Merwe, P. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310050110 · Cited by 43 · see citing works
Kaser, A., Hava, D. L., Dougan, S. K., Chen, Z., Zeißig, S., Brenner, M. B., & Blumberg, R. S. (2008) · European Journal of Immunology · doi:10.1002/eji.200738102 · Cited by 43 · see citing works
Carbohydrate specificity of the recognition of diverse glycolipids by natural killer T cells
Zajonc, D. M., & Kronenberg, M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00802.x · Cited by 43 · see citing works
Saposins utilize two strategies for lipid transfer and CD1 antigen presentation
León, L., Tatituri, R. V. V., Grenha, R., Sun, Y., Barral, D. C., Minnaard, A. J., Bhowruth, V., Veerapen, N., Besra, G. S., Kasmar, A. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200764109 · Cited by 43 · see citing works
My journey into the world of sphingolipids and sphingolipidoses
Sandhoff, K. (2012) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.88.554 · Cited by 42 · see citing works
Self-citationNovel insights into lipid antigen presentation
Libero, G. D., & Mori, L. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.01.005 · Cited by 41 · see citing works
Zajonc, D. M., & Wilson, I. A. (2007) · Springer eBooks · doi:10.1007/978-3-540-69511-0_2 · Cited by 40 · see citing works
Direct Visualization of Saposin Remodelling of Lipid Bilayers
Alattia, J., Shaw, J. E., Yip, C. M., & Privé, G. G. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.08.009 · Cited by 40 · see citing works
Sun, Y., Witte, D. P., Zamzow, M., Ran, H., Quinn, B., Matsuda, J., & Grabowski, G. A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm040 · Cited by 40 · see citing works
Matsuda, J., Yoneshige, A., & Suzuki, K. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04709.x · Cited by 38 · see citing works
Structure, Biosynthesis, and Activities of the Phosphatidyl-myo-Inositol-Based Lipoglycans
Gilleron, M., Jackson, M., Nigou, J., & Puzo, G. (2014) · ASM Press eBooks · doi:10.1128/9781555815783.ch6 · Cited by 38 · see citing works
Lipid metabolism, atherogenesis and CD1-restricted antigen presentation
Major, A. S., Joyce, S., & Kaer, L. V. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.04.004 · Cited by 38 · see citing works
CD1 assembly and the formation of CD1–antigen complexes
Hava, D. L., Brigl, M., van den Elzen, P., Zajonc, D. M., Wilson, I. A., & Brenner, M. B. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.12.003 · Cited by 37 · see citing works
Saposin B binds and transfers phospholipids
Ciaffoni, F., Tatti, M., Boe, A., Salvioli, R., Fluharty, A. L., Sonnino, S., & Vaccaro, A. M. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500547-jlr200 · Cited by 37 · see citing works
The CD1 family: serving lipid antigens to T cells since the Mesozoic era
Zajonc, D. M. (2016) · Immunogenetics · doi:10.1007/s00251-016-0931-0 · Cited by 36 · see citing works
Activation of human T cells by CD 1 and self‐lipids
de Jong, A. (2015) · Immunological Reviews · doi:10.1111/imr.12322 · Cited by 35 · see citing works
Paepe, D. C., Layre, E., Giacometti, G., Garcia-Alles, L. F., Mori, L., Hanau, D., Libero, G. D., de la Salle, H., Puzo, G., & Gilleron, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386300 · Cited by 34 · see citing works
Pei, B., Vela, J. L., Zajonc, D., & Kronenberg, M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06435.x · Cited by 33 · see citing works
The role of oxidised self-lipids and alveolar macrophage CD1b expression in COPD
Ween, M. P., White, J. B., Tran, H. B., Mukaro, V. R., Jones, C., Macowan, M. G., Hodge, G., Trim, P. J., Snel, M. F., & Hodge, S. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-82481-0 · Cited by 31 · see citing works
Vázquez, C. L., Rodgers, A., Herbst, S., Coade, S. B., Gronow, A., Guzmán, C. A., Wilson, M. S., Kanzaki, M., Nykjær, A., & Gutierrez, M. G. (2016) · Scientific Reports · doi:10.1038/srep29332 · Cited by 30 · see citing works
Yoneshige, A., Suzuki, K., Suzuki, K., & Matsuda, J. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22371 · Cited by 30 · see citing works
Nakken, B., Varga, T., Szatmári, I., Széles, L., Gyöngyösi, A., Illarionov, P. A., Dezsö, B., Gogolák, P., Rajnavölgyi, É., & Nagy, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002421 · Cited by 30 · see citing works
Liu, J., Shaji, D., Cho, S., Du, W., Gervay‐Hague, J., & Brutkiewicz, R. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901448 · Cited by 29 · see citing works
How the immune system detects lipid antigens
Libero, G. D., & Mori, L. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.10.002 · Cited by 29 · see citing works
Mechanisms of lipid-antigen generation and presentation to T cells
Libero, G. D., & Mori, L. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.08.001 · Cited by 29 · see citing works
Sphingolipid management by an orchestra of lipid transfer proteins
Neumann, S., & Gerrit van, M. E. E. R. (2008) · Biological Chemistry · doi:10.1515/bc.2008.154 · Cited by 28 · see citing works
CD1-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity
Pereira, C. S., & Macedo, M. F. (2016) · Journal of Immunology Research · doi:10.1155/2016/2876275 · Cited by 27 · see citing works
Presentation of lipid antigens to T cells
Mori, L., & Libero, G. D. (2008) · Immunology Letters · doi:10.1016/j.imlet.2007.11.027 · Cited by 27 · see citing works
A novel saposin-like protein of Entamoeba histolytica with membrane-fusogenic activity
Winkelmann, J., Leippe, M., & Bruhn, H. D. (2006) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2006.01.010 · Cited by 27 · see citing works
- Authors
- Winau, F., Schwierzeck, V., Hurwitz, R., Remmel, N., Sieling, P. A., Modlin, R. L., Porcelli, S. A., Brinkmann, V., Sugita, M., Sandhoff, K., Kaufmann, S. H. E., & Schaible, U. E.
- Affiliations
- Max Planck Society (DE)
- University of California, Los Angeles (US)
- Albert Einstein College of Medicine (US)
- Nippon Medical School (JP)
- Corresponding author
- Kaufmann, Stefan H E
- ORCID
- Venue
- Nature Immunology
- Published
- 2004-01-11
- Volume
- 5
- Issue
- 2
- Pages
- 169-174
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2027841252
- Cited by
- 168
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 4 · 2012: 9
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Update notices
- erratum (2004-03-01)
- Open access
- closed
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- saposin C, CD1b, lipid antigen presentation, Mycobacterium tuberculosis, sphingolipid activator proteins, antigen loading, T cell activation
- MeSH terms
- Antigen-Presenting Cells, beta-Glucosidase, Fibroblasts, Glycoproteins, Humans, Lipids, Lymphocyte Activation, Lysosomes, Protein Binding, T-Lymphocytes, Transfection, Antigen Presentation, Antigens, CD1, Sphingolipid Activator Proteins, Saposins, In Vitro Techniques
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