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Support for the Prion Hypothesis for Inheritance of a Phenotypic Trait in Yeast
Abstract
A cytoplasmically inherited genetic element in yeast, [ PSI + ], was confirmed to be a prionlike aggregate of the cellular protein Sup35 by differential centrifugation analysis and microscopic localization of a Sup35—green fluorescent protein fusion. Aggregation depended on the intracellular concentration and functional state of the chaperone protein Hsp104 in the same manner as did [ PSI + ] inheritance. The amino-terminal and carboxy-terminal domains of Sup35 contributed to the unusual behavior of [ PSI + ]. [ PSI + ] altered the conformational state of newly synthesized prion proteins, inducing them to aggregate as well, thus fulfilling a major tenet of the prion hypothesis.
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Cited by
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373
Cellular Defenses against Unfolded Proteins
Sherman, M. Y., & Goldberg, A. L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00177-5 · Cited by 991
Serio, T. R., Cashikar, A. G., Kowal, A. S., Sawicki, G. J., Moslehi, J. J., Serpell, L., Arnsdorf, M. F., & Lindquist, S. L. (2000) · Science · doi:10.1126/science.289.5483.1317 · Cited by 963
Self-citationPrions as adaptive conduits of memory and inheritance
Shorter, J., & Lindquist, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1616 · Cited by 555
Self-citationTransgenerational epigenetic inheritance: how important is it?
Grossniklaus, U., Kelly, W. G., Ferguson-Smith, A. C., Pembrey, M., & Lindquist, S. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3435 · Cited by 301
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Metadata
- Authors
- Patino, M. M., Liu, J.-J., Glover, J. R., & Lindquist, S.
- Venue
- Science
- Published
- 1996-08-02
- Volume
- 273
- Issue
- 5275
- Pages
- 622-626
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989172027
- Cited by
- 611
- References
- 0
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Patino, M. M., Liu, J.-J., Glover, J. R., & Lindquist, S. (1996). Support for the Prion Hypothesis for Inheritance of a Phenotypic Trait in Yeast. Science. https://doi.org/10.1126/science.273.5275.622
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