The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
Abstract
A signaling pathway has been elucidated whereby growth factors activate the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB), a critical regulator of immediate early gene transcription. Growth factor-stimulated CREB phosphorylation at serine-133 is mediated by the RAS-mitogen-activated protein kinase (MAPK) pathway. MAPK activates CREB kinase, which in turn phosphorylates and activates CREB. Purification, sequencing, and biochemical characterization of CREB kinase revealed that it is identical to a member of the pp90 RSK family, RSK2. RSK2 was shown to mediate growth factor induction of CREB serine-133 phosphorylation both in vitro and in vivo. These findings identify a cellular function for RSK2 and define a mechanism whereby growth factor signals mediated by RAS and MAPK are transmitted to the nucleus to activate gene expression.
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Sun, H., Charles, C. H., Lau, L. F., & Tonks, N. K. (1993) · Cell · doi:10.1016/0092-8674(93)90383-2 · Cited by 1,156
Bjørbæk, C., Vik, T. A., Echwald, S. M., Yang, P.-Y., Vestergaard, H., Wang, J. P., Webb, G. C., Richmond, K., Hansen, T., Erikson, R. L., et al. (1995) · Diabetes · doi:10.2337/diab.44.1.90 · Cited by 59
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Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,382
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274
Transcriptional regulation by the phosphorylation-dependent factor CREB
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Function and regulation of CREB family transcription factors in the nervous system
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Metadata
- Authors
- Xing, J., Ginty, D. D., & Greenberg, M. E.
- Venue
- Science
- Published
- 1996-08-16
- Volume
- 273
- Issue
- 5277
- Pages
- 959-963
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081524299
- Cited by
- 1,248
- References
- 2
- FWCI
- 25.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xing, J., Ginty, D. D., & Greenberg, M. E. (1996). Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase. Science. https://doi.org/10.1126/science.273.5277.959
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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