Cited by 2,127Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

Function and regulation of CREB family transcription factors in the nervous system

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Lonze, Bonnie E, Ginty, David D·2002·Neuron

Abstract

CREB and its close relatives are now widely accepted as prototypical stimulus-inducible transcription factors. In many cell types, these factors function as effector molecules that bring about cellular changes in response to discrete sets of instructions. In neurons, a wide range of extracellular stimuli are capable of activating CREB family members, and CREB-dependent gene expression has been implicated in complex and diverse processes ranging from development to plasticity to disease. In this review, we focus on the current level of understanding of where, when, and how CREB family members function in the nervous system.

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  1. [1]1. Abel, T ∙ Nguyen, P.V ∙ Barad, M ... Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory Cell. 1997; 88:615-626 Full Text Full Text (PDF) Scopus (713) PubMed Google Scholar
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  3. [3]3. Alberini, C.M ∙ Ghirardi, M ∙ Metz, R ... C/EBP is an immediate-early gene required for the consolidation of long- term facilitation in Aplysia Cell. 1994; 76:1099-1114

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Authors
Lonze, B. E., & Ginty, D. D.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Ginty, David D
Venue
Neuron
Publisher
Elsevier BV
Published
2002-08
Volume
35
Issue
4
Pages
605-623
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2068412840
Cited by
2,127
References
15
Citations by year
2026: 42 · 2025: 75 · 2024: 58 · 2023: 56 · 2022: 65 · 2021: 70 · 2020: 81 · 2019: 74 · 2018: 88 · 2017: 84 · 2016: 107 · 2015: 87 · 2014: 100 · 2013: 110 · 2012: 118
FWCI
7.77
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS 34814)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
CREB, neuronal gene expression, brain development, synaptic plasticity, neurodegeneration, transcriptional regulation, extracellular stimuli
MeSH terms
Animals, Central Nervous System Diseases, Circadian Rhythm, Humans, Memory, Nervous System, Neural Pathways, Neuronal Plasticity, Neurons, Signal Transduction, Cyclic AMP Response Element-Binding Protein, Gene Expression Regulation, Developmental

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