Function and regulation of CREB family transcription factors in the nervous system
Open accessAbstract
CREB and its close relatives are now widely accepted as prototypical stimulus-inducible transcription factors. In many cell types, these factors function as effector molecules that bring about cellular changes in response to discrete sets of instructions. In neurons, a wide range of extracellular stimuli are capable of activating CREB family members, and CREB-dependent gene expression has been implicated in complex and diverse processes ranging from development to plasticity to disease. In this review, we focus on the current level of understanding of where, when, and how CREB family members function in the nervous system.
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NMDAR-mediated calcium influx increases pCREB levels through several signaling pathways.
“NMDAR (N-methyl-D-aspartate receptors)-mediated calcium influx is known to increase pCREB levels through several signaling pathways (65).”
CREB is important for cell survival.
“CREB is also important for cell survival (65,66).”
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Susick, L. L., Lowing, J. L., Bosse, K. E., Hildebrandt, C. C., Chrumka, A. C., & Conti, A. C. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.031 · Cited by 11 · see citing works
Kim, K.-S., Kim, H., Park, S.-K., & Han, P.-L. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.016 · Cited by 10 · see citing works
- Authors
- Lonze, B. E., & Ginty, D. D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ginty, David D
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 35
- Issue
- 4
- Pages
- 605-623
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2068412840
- Cited by
- 2,127
- References
- 15
- Citations by year
- 2026: 42 · 2025: 75 · 2024: 58 · 2023: 56 · 2022: 65 · 2021: 70 · 2020: 81 · 2019: 74 · 2018: 88 · 2017: 84 · 2016: 107 · 2015: 87 · 2014: 100 · 2013: 110 · 2012: 118
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 34814)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- CREB, neuronal gene expression, brain development, synaptic plasticity, neurodegeneration, transcriptional regulation, extracellular stimuli
- MeSH terms
- Animals, Central Nervous System Diseases, Circadian Rhythm, Humans, Memory, Nervous System, Neural Pathways, Neuronal Plasticity, Neurons, Signal Transduction, Cyclic AMP Response Element-Binding Protein, Gene Expression Regulation, Developmental
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