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A Crosslinked Cofactor in Lysyl Oxidase: Redox Function for Amino Acid Side Chains
Abstract
A previously unknown redox cofactor has been identified in the active site of lysyl oxidase from the bovine aorta. Edman sequencing, mass spectrometry, ultraviolet-visible spectra, and resonance Raman studies showed that this cofactor is a quinone. Its structure is derived from the crosslinking of the ε-amino group of a peptidyl lysine with the modified side chain of a tyrosyl residue, and it has been designated lysine tyrosylquinone. This quinone appears to be the only example of a mammalian cofactor formed from the crosslinking of two amino acid side chains. This discovery expands the range of known quino-cofactor structures and has implications for the mechanism of their biogenesis.
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Citations
Cited by
Lloyd, S. (1996) · Science · doi:10.1126/science.273.5278.1073 · Cited by 3,088
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Viguet-Carrin, S., Garnero, P., & Delmas, P. D. (2006) · Osteoporosis International · doi:10.1007/s00198-005-2035-9 · Cited by 1,047
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
Kagan, H. M., & Li, W. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10413 · Cited by 954
Self-citationCopper, lysyl oxidase, and extracellular matrix protein cross-linking
Rucker, R., Kosonen, T., Clegg, M., Mitchell, A., Rucker, B., Uriu-Hare, J., & Keen, C. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.5.996s · Cited by 371
Facile DNA immobilization on surfaces through a catecholamine polymer
Ham, H. O., Liu, Z., Lau, K. H. A., Lee, H., & Messersmith, P. B. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005001 · Cited by 189
Metadata
- Authors
- Wang, S. X., Mure, M., Medzihradszky, K. F., Burlingame, A. L., Brown, D. E., Dooley, D. M., Smith, A. J., Kagan, H. M., & Klinman, J. P.
- Venue
- Science
- Published
- 1996-08-23
- Volume
- 273
- Issue
- 5278
- Pages
- 1078-1084
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979098362
- Cited by
- 339
- References
- 0
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, S. X., Mure, M., Medzihradszky, K. F., Burlingame, A. L., Brown, D. E., Dooley, D. M., Smith, A. J., Kagan, H. M., & Klinman, J. P. (1996). A Crosslinked Cofactor in Lysyl Oxidase: Redox Function for Amino Acid Side Chains. Science. https://doi.org/10.1126/science.273.5278.1078
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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