The role of collagen in bone strength

Viguet-Carrin, S.; Garnero, P.; Delmas, P. D.

doi:10.1007/s00198-005-2035-9

Cited by 1,047Bone health and osteoporosis researchConnective tissue disorders researchCollagen: Extraction and Characterization

The role of collagen in bone strength

Viguet-Carrin, S., Garnero, P., Delmas, P. D.·2006·Osteoporosis International

DOI 10.1007/s00198-005-2035-9

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Abstract

Bone is a complex tissue of which the principal function is to resist mechanical forces and fractures. Bone strength depends not only on the quantity of bone tissue but also on the quality, which is characterized by the geometry and the shape of bones, the microarchitecture of the trabecular bones, the turnover, the mineral, and the collagen. Different determinants of bone quality are interrelated, especially the mineral and collagen, and analysis of their specific roles in bone strength is difficult. This review describes the interactions of type I collagen with the mineral and the contribution of the orientations of the collagen fibers when the bone is submitted to mechanical forces. Different processes of maturation of collagen occur in bone, which can result either from enzymatic or nonenzymatic processes. The enzymatic process involves activation of lysyl oxidase, which leads to the formation of immature and mature crosslinks that stabilize the collagen fibrils. Two type of nonenzymatic process are described in type I collagen: the formation of advanced glycation end products due to the accumulation of reducible sugars in bone tissue, and the process of racemization and isomerization in the telopeptide of the collagen. These modifications of collagen are age-related and may impair the mechanical properties of bone. To illustrate the role of the crosslinking process of collagen in bone strength, clinical disorders associated with bone collagen abnormalities and bone fragility, such as osteogenesis imperfecta and osteoporosis, are described.

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Collagen plays a critical role in the structure and function of bone tissue.
“In fact, it is known that collagen plays a critical role in the structure and function of bone tissue [120].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [120]

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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
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Authors: Viguet-Carrin, S., Garnero, P., & Delmas, P. D.
Affiliations: Lyon 1 Université (FR)
Corresponding author: Delmas, P. D.
ORCID: Garnero, P.
Venue: Osteoporosis International
Publisher: Springer Science and Business Media LLC
Published: 2005-12-09
Volume: 17
Issue: 3
Pages: 319-336
ISSN: 0937-941X (ISSN-L)
1433-2965
DOI: 10.1007/s00198-005-2035-9
OpenAlex: W2132551393
Cited by: 1,047
References: 150
Citations by year: 2026: 28 · 2025: 55 · 2024: 54 · 2023: 62 · 2022: 61 · 2021: 64 · 2020: 75 · 2019: 65 · 2018: 105 · 2017: 45 · 2016: 44 · 2015: 64 · 2014: 52 · 2013: 46 · 2012: 48
FWCI: 22.16
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Osteoporosis International (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Keywords: type I collagen, bone strength, bone quality, collagen mineralization, collagen cross-linking, lysyl oxidase, advanced glycation end products, collagen telopeptides, collagen maturation, bone fragility, osteogenesis imperfecta, osteoporosis, bone mechanical properties
MeSH terms: Animals, Biomechanical Phenomena, Bone Development, Bone Matrix, Collagen, Humans, Osteoporosis, Bone Density, Bone Remodeling, Fractures, Bone

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The role of collagen in bone strength

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