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Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels
Abstract
Aquaporin1, a six-transmembrane domain protein, is a water channel present in many fluid-secreting and -absorbing cells. In Xenopus oocytes injected with aquaporin1 complementary RNA, the application of forskolin or cyclic 8-bromo- adenosine 3′,5′-monophosphate increased membrane permeability to water and triggered a cationic conductance. The cationic conductance was also induced by direct injection of protein kinase A (PKA) catalytic subunit, reduced by the kinase inhibitor H7, and blocked by HgCl 2 , an inhibitor of aquaporin1. The cationic permeability of the aquaporin1 channel is activated by a cyclic adenosine monophosphate-dependent mechanism that may involve direct or indirect phosphorylation by PKA.
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Cited by
Liu, K., Kozono, D., Kato, Y., Agre, P., Hazama, A., & Yasui, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409232102 · Cited by 84
Metadata
- Authors
- Yool, A. J., Stamer, W. D., & Regan, J. W.
- Venue
- Science
- Published
- 1996-08-30
- Volume
- 273
- Issue
- 5279
- Pages
- 1216-1218
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031638883
- Cited by
- 173
- References
- 0
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels. https://app.cochat.ai/papers/10.1126/science.273.5279.1216
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- Yool, A. J., Stamer, W. D., & Regan, J. W. (1996). Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels. Science. https://doi.org/10.1126/science.273.5279.1216
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
